{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T20:56:45Z","timestamp":1782939405550,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,1,4]],"date-time":"2012-01-04T00:00:00Z","timestamp":1325635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p>Recent studies suggest that phytoestrogens may exert a protective effect against osteoporosis. This study examined whether treatment with phytoestrogen extracts from<jats:italic>Saururus chinensis<\/jats:italic>(SC) exerted a preventive effect on estrogen\u2010deficiency\u2010induced osteoporosis. Six\u2010 to seven\u2010month\u2010old female Sprague\u2013Dawley rats were randomly assigned into either a sham\u2010operated group or one of three ovariectomy (OVX) subgroups: OVX treated with vehicle, OVX with alendronate, and OVX with SC extract (SC). Rats began receiving treatment 4\u2009weeks before the OVX treatment and continued receiving treatment for an additional 10\u2009weeks after OVX (for a combined total of 14\u2009weeks). The results showed that the SC treatment prevented loss of femur bone mineral density after OVX, as determined by a significant decrease in the levels of serum bone turnover markers osteocalcin and alkaline phosphatase as well as urinary deoxypyridinoline. Micro\u2010computed tomography analysis showed that the SC treatment significantly prevented decreases in bone volume\/tissue volume, trabecular number and trabecular thickness, while also preventing an increase in trabecular separation. It was concluded that SC treatment could prevent OVX\u2010induced loss of bone mass and deterioration in trabecular microarchitecture by suppressing bone turnover, thereby maintaining bone structural integrity. Further, no stimulation of proliferation of uterine tissue was noted. Therefore, it is suggested that treatment with<jats:italic>S. chinensis<\/jats:italic>extracts might be a potential alternative therapy for treating postmenopausal osteoporosis. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.3714","type":"journal-article","created":{"date-parts":[[2012,1,5]],"date-time":"2012-01-05T04:03:27Z","timestamp":1325736207000},"page":"1182-1188","source":"Crossref","is-referenced-by-count":15,"title":["Antiosteoporotic Activity of<i>Saururus chinensis<\/i>Extract in Ovariectomized Rats"],"prefix":"10.1002","volume":"26","author":[{"given":"Mi Jeong","family":"Sung","sequence":"first","affiliation":[{"name":"Research Division Emerging Innovative Technology Korea Food Research Institute Songnam Keongki Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munkhtugs","family":"Davaatseren","sequence":"additional","affiliation":[{"name":"Research Division Emerging Innovative Technology Korea Food Research Institute Songnam Keongki Republic of Korea"},{"name":"Food Biotechnology University of Science and Technology Daejeon Republic of 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