{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T17:40:49Z","timestamp":1780940449195,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,4,18]],"date-time":"2012-04-18T00:00:00Z","timestamp":1334707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010027","name":"University of Greenwich","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100010027","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:p><jats:italic>Cassia auriculata<\/jats:italic> (Caesalpiniaceae) is a common Asian beverage and medicinal plant widely used in tradition medicine for diabetes, hyperlipidemia and various other disease conditions. Previous studies on crude extracts of <jats:italic>C. auriculata<\/jats:italic> have documented the scientific basis for some of its traditional medicinal uses. The present study investigates the antilipase activity of the ethanol extract of the aerial parts along with the previously isolated compounds (kaempferol\u20103\u2010<jats:italic>O<\/jats:italic>\u2010rutinoside, rutin, kaempferol, quercetin and luteolin). The crude extract displayed inhibitory activity against pancreatic lipase with IC<jats:sub>50<\/jats:sub> of 6.0\u2009\u00b1\u20091.0\u2009\u00b5g\/mL. The most active antilipase compound was kaempferol\u20103\u2010<jats:italic>O<\/jats:italic>\u2010rutinoside with IC<jats:sub>50<\/jats:sub> value (2.9\u2009\u00b1\u20090.50\u2009\u03bcM) only about twice weaker than the standard antilipase drug, orlistat (IC<jats:sub>50<\/jats:sub>\u2009=\u20091.45\u2009\u00b1\u20090.26\u2009\u03bcM). Luteolin, quercetin and rutin were found to be weak pancreatic lipase inhibitors (IC<jats:sub>50<\/jats:sub> over 100\u2009\u03bcM), whereas kaempferol showed no activity up to 250\u2009\u03bcM. The antihyperlipidemic effect of <jats:italic>C. auriculata<\/jats:italic> could be attributed to direct lipase inhibitory effect of the plant constituents. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.4711","type":"journal-article","created":{"date-parts":[[2012,4,18]],"date-time":"2012-04-18T05:54:46Z","timestamp":1334728486000},"page":"152-155","source":"Crossref","is-referenced-by-count":51,"title":["Antihyperlipidemic Components of <i>Cassia auriculata<\/i> Aerial Parts: Identification Through <i>In Vitro<\/i> Studies"],"prefix":"10.1002","volume":"27","author":[{"given":"Solomon","family":"Habtemariam","sequence":"first","affiliation":[{"name":"Pharmacognosy Research Laboratories, Medway School of Science University of Greenwich  Central Avenue Chatham\u2010Maritime Kent ME4 4TB 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