{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:46:28Z","timestamp":1790891188484,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,5,8]],"date-time":"2012-05-08T00:00:00Z","timestamp":1336435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:p>Guava leaf tea (GLT) contains guava leaf polyphenol (Gvpp), which regulates the absorption of dietary carbohydrate from the intestines. Borderline diabetics, who are at high risk of development of diabetes, take GLT to suppress a rapid increase of blood sugar level after meals. However, patients with diabetes in whom diabetic drugs or warfarin as a blood thinner are prescribed also take GLT with the expectation of glycemic control. Therefore, we studied whether GLT had potential for inhibition or induction of cytochrome P450 (CYP) and an influence on the action of warfarin. Extract of guava leaf (GvEx) consists of carbohydrate and polyphenols, which are Gvpp, quercetin, and ellagic acid. These polyphenols, but not GvEx, showed a certain level of inhibition of human\u2010cDNA\u2010expressed CYPs. In a comparison of GLT and grapefruit juice, GLT showed weaker inhibition of CYP activities and of midazolam 1\u2032\u2010hydroxylation than grapefruit juice. Furthermore, neither liver weight nor CYP3A expression in the liver was changed in rats that received GvEx for 90\u2009days compared with the control group. When rats were concomitantly treated with GLT and warfarin, the prolongation of clotting time of blood by warfarin was not influenced. These data suggest that GLT is unlikely to interact with drugs. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.4724","type":"journal-article","created":{"date-parts":[[2012,5,8]],"date-time":"2012-05-08T07:29:17Z","timestamp":1336462157000},"page":"299-305","source":"Crossref","is-referenced-by-count":17,"title":["Evaluation of Food\u2013drug Interaction of Guava Leaf Tea"],"prefix":"10.1002","volume":"27","author":[{"given":"Kimiyuki","family":"Kaneko","sequence":"first","affiliation":[{"name":"Safety Research Department Yakult Central Institute for Microbiological Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuya","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Safety Research Department Yakult Central Institute for Microbiological Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emi","family":"Iwadate\u2010Iwata","sequence":"additional","affiliation":[{"name":"Safety Research Department Yakult Central Institute for Microbiological Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuo","family":"Kato","sequence":"additional","affiliation":[{"name":"Safety Research Department Yakult Central Institute for Microbiological Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazumi","family":"Uchida","sequence":"additional","affiliation":[{"name":"Safety Research Department Yakult Central Institute for Microbiological Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaharu","family":"Onoue","sequence":"additional","affiliation":[{"name":"Safety Research Department Yakult Central Institute for Microbiological Research"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,5,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1655997"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1601736"},{"key":"e_1_2_8_4_1","first-page":"19","article-title":"Effectiveness of consecutive ingestion and excess intake of Guava leaves tea in human volunteers","volume":"3","author":"Deguchi Y","year":"2000","journal-title":"J Jpn Counc Adv Food Ingred Res"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1271\/nogeikagaku1924.72.923"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/00498250701883233"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2005.04.055"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2133\/dmpk.21.122"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.04.139"},{"key":"e_1_2_8_10_1","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/S0090-9556(25)07487-2","article-title":"Inhibition and kinetics of cytochrome P4503A activity in microsomes from rat, human, and cDNA\u2010expressed human cytochrome P450","volume":"24","author":"Ghosal A","year":"1996","journal-title":"Drug Metab Dispos"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2007.00011.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.10.1095"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.28.4.536"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2005.pto_157.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2009.10.041"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2008.01.008"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.104.079608"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm800115x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1055\/s-0037-1614485","article-title":"Vitamin K intake and sensitivity to warfarin in patients consuming regular diets","volume":"81","author":"Lubetsky A","year":"1999","journal-title":"Thromb Haemost"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.53.267"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.FP0061311"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.5520340108"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.5.3.433"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/82.6.900"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2007.08.018"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(03)00420-X"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.31.5.533"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.31.68"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.2000.1835"},{"key":"e_1_2_8_30_1","first-page":"379","article-title":"Ground\u2010glass hepatocytes: light and electron microscopy. Characterization of the different types","volume":"5","author":"V\u00e1zquez JJ","year":"1990","journal-title":"Histol Histopathol"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/0091270004270642"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.30.9.977"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(02)01913-6"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.4724","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.4724","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.4724","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T13:00:05Z","timestamp":1743080405000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.4724"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,8]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["10.1002\/ptr.4724"],"URL":"https:\/\/doi.org\/10.1002\/ptr.4724","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,8]]}}}