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In the present study, the hypocholesterolemic and hepatoprotective effects of the dietary consumption of chlorogenic acid were investigated by monitoring plasma lipid profile (total cholesterol, triglycerides, high\u2010density lipoprotein and low\u2010density lipoprotein) in Sprague\u2013Dawley rats fed with a normal diet, a high\u2010cholesterol diet or a high\u2010cholesterol diet supplemented with chlorogenic acid (1 or 10 mg\/kg\/day p.o.) for 28 days. Chlorogenic acid markedly altered the increased plasma total cholesterol and low\u2010density lipoprotein but decreased high\u2010density lipoprotein induced by a hypercholesterolemic diet with a dose\u2010dependent improvement on both atherogenic index and cardiac risk factor. Lipid depositions in liver were attenuated significantly in hypercholesterolemic animals supplemented with chlorogenic acid. It is postulated that hypocholesterolemic effect is the primary beneficial effect given by chlorogenic acid, which leads to other secondary beneficial effects such as atheroscleroprotective, cardioprotective and hepatoprotective functions. The hypocholesterolemic functions of chlorogenic acid are probably due to the increase in fatty acids unitization in liver via the up\u2010regulation of peroxisome proliferation\u2010activated receptor \u03b1 mRNA. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.4751","type":"journal-article","created":{"date-parts":[[2012,6,6]],"date-time":"2012-06-06T12:38:02Z","timestamp":1338986282000},"page":"545-551","source":"Crossref","is-referenced-by-count":203,"title":["Chlorogenic Acid Exhibits Cholesterol Lowering and Fatty Liver Attenuating Properties by Up\u2010regulating the Gene Expression of PPAR\u2010\u03b1 in Hypercholesterolemic Rats Induced with a High\u2010Cholesterol Diet"],"prefix":"10.1002","volume":"27","author":[{"given":"Chun\u2010Wai","family":"Wan","sequence":"first","affiliation":[{"name":"Food Safety and Technology Research Centre, Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic University  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candy Ngai\u2010Yan","family":"Wong","sequence":"additional","affiliation":[{"name":"Food Safety and Technology Research Centre, Department of 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