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In the current study, biochemical and haematological evaluations of ethanolic leaf extracts derived from such plants (EAA) were carried out in 20 male Wistar rats. Rats were divided into four study groups of saline\u2010treated (control) and test groups exposed orally to graded doses of EAA for 28 days. The results showed that the liver function and haematological indices, and testosterone levels were not adversely affected. High density lipoprotein \u2010cholesterol was reduced at 100\u2009mg\/kg of EAA, atherogenic index as well as low density lipoprotein \u2010cholesterol was raised, and glucose concentration was reduced significantly at the 100 and 200\u2009mg\/kg of EAA (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). In addition to serving as a possible antidiabetic agent, EAA may not predispose users to hepatotoxicity, haematotoxicity and testicular toxicity. However, due to the possible risk of atherosclerosis, we advise that the plant extract should be taken with caution in people with atherosclerotic condition. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.4758","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T17:01:13Z","timestamp":1340816473000},"page":"602-609","source":"Crossref","is-referenced-by-count":13,"title":["Biochemical and Haematological Evaluation of Repeated Dose Exposure of Male Wistar Rats to an Ethanolic Extract of <i>Artemisia annua<\/i>"],"prefix":"10.1002","volume":"27","author":[{"given":"Mbeh U.","family":"Eteng","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Faculty of Basic Medical Sciences University of Calabar  P.M.B. 1115 Calabar Cross River State Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amos O.","family":"Abolaji","sequence":"additional","affiliation":[{"name":"Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences University of Karachi  Karachi 75270 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