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In 2003, a review by the FDA Subcommittee on Oral Health Care Drug Products for Over\u2010the\u2010Counter Human Use concluded that the product is effective and safe, and a review of studies published in the meantime showed that Listerine\u00ae fulfils the consensus criteria for an effective antigingivitis\/antiplaque product. However, concerns have been raised about the long\u2010term safety of some of the ingredients, particularly the ethanol content, and in the light of these concerns, the evidence has been re\u2010examined for both the efficacy and safety of Listerine\u00ae. In summary, the studies support the claim that Listerine\u00ae shows benefit for oral health, but the concerns over its safety remain to be clarified. Until these have been addressed, high risk populations (children, alcohol addicts, patients with genetic deficiencies in ethanol metabolism) should use alcohol\u2010free mouthwashes for the maintenance of oral health. 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