{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T08:00:52Z","timestamp":1777363252758,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,7,17]],"date-time":"2012-07-17T00:00:00Z","timestamp":1342483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:p>In order to investigate the potential use of <jats:italic>Boldoa purpurascens<\/jats:italic> against diabetes, the antihyperglycemic effect of an ethanol extract obtained from its leaves was evaluated at doses of 50, 100 and 200 mg\/kg in rats after induction of hyperglycemia by alloxan. Insulin 5 IU\/kg was used as positive control and NaCl 0.9% as negative control. A similar experiment was performed with the aqueous extract used at doses of 50 and 100 mg\/kg using metformin at a dose of 50mg\/kg as positive control. Statistical analysis was carried using the Kruskal\u2013Wallis test with an interval of trust of 99%. The ethanolic and aqueous extract of <jats:italic>B. purpurascens<\/jats:italic> showed a significant decrease of blood glucose levels 72 h after administration. Phytochemical analysis of the ethanol extract showed the presence of D\u2010pinitol, a compound known for its hypoglycemic properties. In conclusion, ethanolic as well as aqueous extracts of <jats:italic>B. purpurascens<\/jats:italic> leaves show antihyperglycemic activity, possibly due to the presence of D\u2010pinitol and flavonoids. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.4769","type":"journal-article","created":{"date-parts":[[2012,7,19]],"date-time":"2012-07-19T05:28:21Z","timestamp":1342675701000},"page":"721-724","source":"Crossref","is-referenced-by-count":9,"title":["Antihyperglycemic Activity of Extracts from <i>Boldoa purpurascens<\/i> Leaves in Alloxan\u2010Induced Diabetic Rats"],"prefix":"10.1002","volume":"27","author":[{"given":"D. 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