{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T02:59:38Z","timestamp":1771469978260,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,8,16]],"date-time":"2012-08-16T00:00:00Z","timestamp":1345075200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:p>The tea from the white mulberry (<jats:italic>Morus alba<\/jats:italic> L.) leaf is a worldwide known traditional medicine of type II diabetes. Here, we report the investigation of the dichloromethane\u2010soluble fraction obtained in a 0.24% m\/m yield from the hot water extract of mulberry leaves. A significant, dose\u2010dependent activity was found by means of the 24\u2010h glucose consumption of fully differentiated adipocytes both in the absence and presence of insulin. The fraction was characterized by HPLC\u2010DAD, GC\u2010MS and GC\u2010FID. The main constituent (40.3% by means of GC\u2010FID) was isolated and identified as loliolide by EIMS, HRESIMS and NMR spectroscopy. In the active fraction benzyl alcohol, ethyl benzoate, <jats:italic>t<\/jats:italic>\u2010cinnamic acid, <jats:italic>p<\/jats:italic>\u2010hydroxyacetophenone, <jats:italic>t<\/jats:italic>\u2010coniferyl alcohol and synapil alcohol were also identified by GC\u2010MS and quantified by GC\u2010FID (0.7, 1.3, 1.5, 2.9, 7.5 and 2.6%, respectively). Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.4803","type":"journal-article","created":{"date-parts":[[2012,8,16]],"date-time":"2012-08-16T06:28:35Z","timestamp":1345098515000},"page":"847-851","source":"Crossref","is-referenced-by-count":24,"title":["<i>In vitro<\/i> Anti\u2010diabetic Activity and Chemical Characterization of an Apolar Fraction of <i>Morus alba<\/i> Leaf Water Extract"],"prefix":"10.1002","volume":"27","author":[{"given":"Attila","family":"Hunyadi","sequence":"first","affiliation":[{"name":"Institute of Pharmacognosy University of Szeged  E\u00f6tv\u00f6s str. 6 6720 Szeged Hungary"},{"name":"COST Action CM0804 Chemical Biology with Natural Products of the European Commission  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katalin","family":"Veres","sequence":"additional","affiliation":[{"name":"Institute of Pharmacognosy University of Szeged  E\u00f6tv\u00f6s str. 6 6720 Szeged Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Balazs","family":"Danko","sequence":"additional","affiliation":[{"name":"Institute of Pharmacognosy University of Szeged  E\u00f6tv\u00f6s str. 6 6720 Szeged Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoltan","family":"Kele","sequence":"additional","affiliation":[{"name":"Department of Medical Chemistry University of Szeged  D\u00f3m t\u00e9r 8 6720 Szeged Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edit","family":"Weber","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Chemistry University of Szeged  E\u00f6tv\u00f6s str. 6 6720 Szeged Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anasztazia","family":"Hetenyi","sequence":"additional","affiliation":[{"name":"Department of Medical Chemistry University of Szeged  D\u00f3m t\u00e9r 8 6720 Szeged Hungary"},{"name":"Institute of Pharmaceutical Chemistry University of Szeged  E\u00f6tv\u00f6s str. 6 6720 Szeged Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Istvan","family":"Zupko","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics and Biopharmacy University of Szeged  E\u00f6tv\u00f6s str. 6 6720 Szeged Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tusty\u2010Jiuan","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Kaohsiung Medical University  100 ShihChuan 1st rd. 807 Kaohsiung Taiwan, R.O.C."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,8,16]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Identification of Essential Oil Components by Gas Chromatography \/ Mass Spectrometry","author":"Adams RP","year":"2007"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf801208t"},{"key":"e_1_2_7_4_1","first-page":"47","article-title":"Effect of mulberry (Morus alba L.) therapy on plasma and erythrocyte membrane lipids in patients with type 2 diabetes. 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