{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:57:21Z","timestamp":1789646241112,"version":"4.0.0"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,8,23]],"date-time":"2012-08-23T00:00:00Z","timestamp":1345680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:p>The antifungal activity of hexane, dichloromethane, methanol and aqueous extracts from the rhizome and root of <jats:italic>Ferula hermonis<\/jats:italic> was assayed <jats:italic>in vitro<\/jats:italic> by the agar disk diffusion method against a panel of human opportunistic and pathogenic fungi. Among them, the hexane and dichloromethane extracts showed the highest activity particularly against the dermatophytes <jats:italic>Microsporum gypseum<\/jats:italic> and <jats:italic>Tricophyton mentagrophytes<\/jats:italic> as well as the yeast <jats:italic>Candida lactis\u2010condensi<\/jats:italic>. Activity\u2010guided fractionation of both extracts using an agar overlay bioautographic method led to the isolation of two antifungal compounds which were identified as the daucane aryl esters jaeschkeanadiol <jats:italic>p<\/jats:italic>\u2010hydroxybenzoate (ferutinin) and jaeschkeanadiol benzoate (teferidin). Determination of minimal inhibitory concentration (MIC) and minimal fungicidal concentration (MFC) values of both compounds evidenced a stronger antifungal activity for ferutinin than for teferidin. Particularly, <jats:italic>T. mentagrophytes<\/jats:italic> was the most sensitive strain with MIC and MFC values ranging from 8 to 256 \u00b5g\/mL. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.4806","type":"journal-article","created":{"date-parts":[[2012,8,24]],"date-time":"2012-08-24T04:03:17Z","timestamp":1345780997000},"page":"911-915","source":"Crossref","is-referenced-by-count":18,"title":["Antifungal Compounds from the Rhizome and Roots of <i>Ferula hermonis<\/i>"],"prefix":"10.1002","volume":"27","author":[{"given":"Abdel\u2010Hadi","family":"Al\u2010Ja'fari","sequence":"first","affiliation":[{"name":"Unitat de Farmacologia i Farmacogn\u00f2sia, Facultat de Farm\u00e0cia Universitat de Barcelona  Av. 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