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Intraperitoneal administration of CCl<jats:sub>4<\/jats:sub> to rats for 8\u2009weeks not only increased the plasma levels of glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) but also induced a marked increase in the formation of hepatic fibrosis. Moreover, the activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx) were also reduced in the liver of rats treated with CCl<jats:sub>4<\/jats:sub>. Oral administration of silymarin (200\u2009mg\/kg, three times daily), in parallel, decreased the plasma levels of GOT and GPT. Furthermore, in addition to the improvement of hepatic fibrosis, the hepatic levels of hydroxyproline and connective tissue growth factor (CTGF) were both markedly decreased by silymarin. Silymarin also elevated the activities of SOD and GPx in liver isolated from CCl<jats:sub>4<\/jats:sub>\u2010treated rats. The results suggest that oral administration of silymarin protects against CCl<jats:sub>4<\/jats:sub>\u2010induced hepatic fibrosis in rats, likely due to the decrease in fibrotic parameters such as CTGF. 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