{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T05:07:54Z","timestamp":1791522474098,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,9,12]],"date-time":"2012-09-12T00:00:00Z","timestamp":1347408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:p><jats:italic>Tabebuia avellanedae<\/jats:italic> (syn. <jats:italic>Handroanthus impetiginosus<\/jats:italic>) is popularly known as \u2018ip\u00ea\u2010roxo\u2019 and has been used in folk medicine as anti\u2010inflammatory and in the treatment of ulcers, bacterial and fungal infections. This study evaluated the gastric ulcer healing property of the ethanolic extract (EET) of barks from <jats:italic>Tabebuia avellanedae<\/jats:italic> and investigated the mechanisms that may underlie this effect. Rats were treated with EET (twice a day for 7 days) after induction of chronic gastric ulcers by 80% acetic acid. Following treatment, histological and immunohistochemical analysis were performed in gastric ulcer tissues. Oral administration of EET (100 and 300 mg\/kg) significantly reduced the gastric lesion induced by acetic acid in 44 and 36%, respectively. Histopathological evaluation demonstrated a contraction of gastric ulcer size, increase of mucus layer (periodic acid\u2010Schiff stained mucin\u2010like glycoproteins) and cell proliferation (proliferating cell nuclear antigen immunohistochemistry) in animals treated with EET (100 and 300 mg\/kg). The results demonstrate that EET significantly accelerates healing of acetic acid induced gastric ulcer in rats through increase of mucus content and cell proliferation, indicating a potential usefulness for treatment of peptic ulcer diseases. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.4835","type":"journal-article","created":{"date-parts":[[2012,9,12]],"date-time":"2012-09-12T06:50:55Z","timestamp":1347432655000},"page":"1067-1073","source":"Crossref","is-referenced-by-count":36,"title":["Antiulcer Effect of Bark Extract of <i>Tabebuia avellanedae<\/i>: Activation of Cell Proliferation in Gastric Mucosa During the Healing Process"],"prefix":"10.1002","volume":"27","author":[{"given":"Isabela Tiemy","family":"Pereira","sequence":"first","affiliation":[{"name":"Department of Pharmacology Federal University of Parana  Curitiba PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00edgia Moura","family":"Burci","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Federal University of Parana  Curitiba PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa Mota","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Federal University of Parana  Curitiba PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiane Hatsuko","family":"Baggio","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Federal University of Parana  Curitiba PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melina","family":"Heller","sequence":"additional","affiliation":[{"name":"Department of Chemistry Federal University of Santa Catarina  Florianopolis SC Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Amadeu","family":"Micke","sequence":"additional","affiliation":[{"name":"Department of Chemistry Federal University of Santa Catarina  Florianopolis SC Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moacir Geraldo","family":"Pizzolatti","sequence":"additional","affiliation":[{"name":"Department of Chemistry Federal University of Santa Catarina  Florianopolis SC Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Consuelo Andrade","family":"Marques","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Federal University of Parana  Curitiba PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Fernanda","family":"de Paula Werner","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Federal University of Parana  Curitiba PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf010827s"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2008.06.016"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-69912010000100010"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2478\/v10042-009-0042-y"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-8741(90)90061-W"},{"key":"e_1_2_7_7_1","first-page":"1","article-title":"Antinociceptive and antiedematogenic properties and acute toxicity of Tabebuia avellanedae Lor. ex Griseb. inner bark aqueous extract","volume":"13","author":"Miranda FG","year":"2001","journal-title":"BMC Pharmacol"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mog.0000245540.87784.75"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2009.12.010"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1987.tb06962.x"},{"key":"e_1_2_7_11_1","first-page":"19","article-title":"Deinstitutionalization of the mentally ill. 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