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Phlorofucofuroeckol\u2010A (PFF) exhibited the highest anti\u2010MRSA activity, with an MIC of 32\u2009\u00b5g\/mL. An investigation of the interaction between these compounds and the \u03b2\u2010lactam antibiotics ampicillin, penicillin, and oxacillin revealed synergistic action against MRSA in combination with compound PFF. To our knowledge, this is the first report on the anti\u2010MRSA activity of phlorotannins from <jats:italic>E. bicyclis<\/jats:italic>. The results obtained in this study suggest that the compounds derived from <jats:italic>E. bicyclis<\/jats:italic> can be a good source of natural antibacterial agents against MRSA. 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