{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T02:35:15Z","timestamp":1767839715168,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,10,29]],"date-time":"2012-10-29T00:00:00Z","timestamp":1351468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:p><jats:italic>Polygonatum verticillatum<\/jats:italic> is commonly used for the treatment of asthma and inflammation. The current study was aimed to scrutinize the pharmacological profile of methanolic extract of the aerial parts (PA). Isolated tracheal preparations were used for the evaluation of bronchodilatory activity, whilst the <jats:italic>in vivo<\/jats:italic> carrageenan\u2010induced paw oedema test and an <jats:italic>in vitro<\/jats:italic> lipoxygenase (LOX) inhibitory assay were used for the assessment of the anti\u2010inflammatory profile of PA. When tested against carbachol and K<jats:sup>+<\/jats:sup> (80\u2009mM)\u2010induced contractions, PA caused complete inhibition of isolated rabbit tracheal preparations in a dose\u2010dependent mode, similar to verapamil. While elucidating possible mechanism, PA shifted the Ca<jats:sup>2+<\/jats:sup> concentration\u2013response curves to the right, analogous to that produced by verapamil, confirming a Ca<jats:sup>2+<\/jats:sup> channel blocker\u2010like activity. PA provoked profound reduction in paw oedema with a maximum protection of 60.87% at 200\u2009mg\/kg i.p. in a dose\u2010dependent manner which was augmented by its prominent LOX inhibitory activity (IC<jats:sub>50<\/jats:sub>: 125\u2009\u00b5g\/mL). These findings authenticated its therapeutic potential in the treatment of asthmatic and inflammatory conditions. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.4860","type":"journal-article","created":{"date-parts":[[2012,10,29]],"date-time":"2012-10-29T17:24:20Z","timestamp":1351531460000},"page":"1288-1292","source":"Crossref","is-referenced-by-count":18,"title":["Bronchodilator Activity of Aerial Parts of <i>Polygonatum verticillatum<\/i> Augmented by Anti\u2010inflammatory Activity: Attenuation of Ca<sup>2+<\/sup> Channels and Lipoxygenase"],"prefix":"10.1002","volume":"27","author":[{"given":"Haroon","family":"Khan","sequence":"first","affiliation":[{"name":"Department of Pharmacy University of Peshawar  Peshawar 25120 Pakistan"},{"name":"Gandhara College of Pharmacy Gandhara University  Peshawar Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Saeed","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Peshawar  Peshawar 25120 Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anwarul Hassan","family":"Gilani","sequence":"additional","affiliation":[{"name":"Natural Product Research Division, Department of Biological and Biomedical Sciences The Aga Khan University Medical College  Karachi 74800 Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malik Hassan","family":"Mehmood","sequence":"additional","affiliation":[{"name":"Natural Product Research Division, Department of Biological and Biomedical Sciences The Aga Khan University Medical College  Karachi 74800 Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Najeeb\u2010ur","family":"Rehman","sequence":"additional","affiliation":[{"name":"Natural Product Research Division, Department of Biological and Biomedical Sciences The Aga Khan University Medical College  Karachi 74800 Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naveed","family":"Muhammad","sequence":"additional","affiliation":[{"name":"Natural Product Research Division, Department of Biological and Biomedical Sciences The Aga Khan University Medical College  Karachi 74800 Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muzaffar","family":"Abbas","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Peshawar  Peshawar 25120 Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikram\u2010ul","family":"Haq","sequence":"additional","affiliation":[{"name":"National Institute of Health  Islamabad 45500 Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,10,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2008.04.022"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161205774370753"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.28.596"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2007.04.059"},{"key":"e_1_2_6_6_1","first-page":"990","article-title":"Studies on Cardio\u2010suppressant, Vasodilator and Tracheal Relaxant Effects of Sarcococca saligna. 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