{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T18:58:01Z","timestamp":1772305081176,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,11,28]],"date-time":"2012-11-28T00:00:00Z","timestamp":1354060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:p><jats:italic>Rhodiola rosea<\/jats:italic>(Rhodiola) is grown at high altitudes and northern latitudes. It is mainly used clinically as an adaptogen, but antihypertensive effects have been reported for the extract. These have not been well investigated, so in the present study, we evaluated the effect of Rhodiola\u2010water extract on blood pressure in spontaneously hypertensive rats (SHRs) and investigated the potential mechanism(s) for this action. In conscious male SHRs, systolic blood pressure (SBP) and heart rate were recorded using the tail\u2010cuff method. Plasma \u03b2\u2010endorphin was measured by enzyme\u2010linked immunosorbent assay. Rhodiola\u2010water extract decreased SBP in SHRs in a dose\u2010dependent manner, and this action was more significant than that in normal group named Wistar\u2010Kyoto (WKY) rats. This reduction of SBP in SHRs was inhibited by pretreatment with the selective opioid \u03bc\u2010receptor antagonist, cyprodime, but not by naloxonazine, an antagonist specific to opioid \u03bc1\u2010receptor. Also, the SBP\u2010lowering action of Rhodiola\u2010water extract was attenuated in adrenalectomized SHRs. Moreover, Rhodiola\u2010water extract dose\u2010dependently increased \u03b2\u2010endorphin release in SHRs, and the elevation of \u03b2\u2010endorphin in SHRs was higher than that in WKY. Thus, we suggest that Rhodiola\u2010water extract can induce release of \u03b2\u2010endorphin to lower SBP in SHRs. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.4900","type":"journal-article","created":{"date-parts":[[2012,11,29]],"date-time":"2012-11-29T02:25:34Z","timestamp":1354155934000},"page":"1543-1547","source":"Crossref","is-referenced-by-count":15,"title":["Rhodiola\u2010Water Extract Induces \u03b2\u2010endorphin Secretion to Lower Blood Pressure in Spontaneously Hypertensive Rats"],"prefix":"10.1002","volume":"27","author":[{"given":"Wei\u2010Jing","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine Chi\u2010Mei Medical Center Yong Kang Tainan City 73101 Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsien\u2010Hui","family":"Chung","sequence":"additional","affiliation":[{"name":"Institute of Basic Medical Sciences, College of Medicine National Cheng Kung University Tainan City 70101 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