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For the first time, the CMI of these plant extracts [cyclohexane, ethanol and ethanol\/water (1:1, v\/v)] was determined against five dermatophytes, five <jats:italic>Candida<\/jats:italic> species, <jats:italic>Scytalidium dimidiatum<\/jats:italic>, a <jats:italic>Malassezia<\/jats:italic> sp. strain and <jats:italic>Pneumocystis carinii<\/jats:italic>. Cytotoxicity tests of the most active extracts were also performed on an HaCat keratinocyte cell line. Results suggest that the extracts of <jats:italic>Bursera simaruba<\/jats:italic>, <jats:italic>Cedrela odorata<\/jats:italic>, <jats:italic>Enterolobium cyclocarpum<\/jats:italic> and <jats:italic>Pluchea carolinensis<\/jats:italic> have interesting activities and could be good candidates for developing antifungal formulations. 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