{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T11:58:30Z","timestamp":1768737510471,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,2,18]],"date-time":"2013-02-18T00:00:00Z","timestamp":1361145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:p>In this paper, the anti\u2010depressant effects of <jats:italic>Acanthopanax senticosus<\/jats:italic> extract (ASE) were studied using animal models of depression including the forced swimming and tail suspension tests. The anti\u2010depressive mechanism of ASE was explored by monitoring the levels of monoamine neurotransmitters including 5\u2010hydroxytrylamine (5\u2010HT), norepinephrine (NE), and dopamine (DA), as well as cAMP response element\u2010binding (CREB) protein expression in the whole brain of mice following the tail suspension test. Our results showed that intragastric administration of ASE at a dose of 2000\u2009mg\/kg for seven days significantly reduced the duration of immobility in both the forced swimming test and the tail suspension test. These results indicate that ASE possesses antidepressant\u2010like properties. Pre\u2010treatment with 2000\u2009mg\/kg of ASE for seven days significantly elevated the levels of 5\u2010HT, NE, and DA in the whole brain of mice. Moreover, ASE at doses of 1000 and 2000\u2009mg\/kg significantly up\u2010regulated the level of CREB protein. Taken together, these findings suggest that the anti\u2010depressive mechanism of ASE may be mediated via the central monoaminergic neurotransmitter system and CREB protein expression. Therefore, administration of ASE may be beneficial for patients with depressive disorders. Copyright \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.4938","type":"journal-article","created":{"date-parts":[[2013,2,18]],"date-time":"2013-02-18T22:30:20Z","timestamp":1361226620000},"page":"1829-1833","source":"Crossref","is-referenced-by-count":40,"title":["Anti\u2010depressant Effects of Aqueous Extract from <i>Acanthopanax senticosus<\/i> in Mice"],"prefix":"10.1002","volume":"27","author":[{"given":"Liji","family":"Jin","sequence":"first","affiliation":[{"name":"School of Life Science and Biotechnology Dalian University of Technology  Dalian 116024 P. R. China"},{"name":"Ministry of Education Center for Food Safety of Animal Origin Dalian University of Technology  Dalian 116620 P. 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