{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:24:36Z","timestamp":1789579476310,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,4,12]],"date-time":"2013-04-12T00:00:00Z","timestamp":1365724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p>This study examines the antiobesity effects of fucoidan in an animal model of diet\u2010induced obesity. Mice were fed a standard diet or high\u2010fat diet (HFD) for 5\u2009weeks. After that, the mice were divided into four experimental groups, with 10 mice per group, including a standard diet group, HFD group, HFD containing 1% fucoidan (HFD\u2009+\u2009FUCO 1%) group and HFD containing 2% fucoidan (HFD\u2009+\u2009FUCO 2%) group. The fucoidan supplementation group had significantly decreased body\u2010weight gain, food efficiency ratio and relative liver and epididymal fat mass compared with the HFD group. The mice supplemented with fucoidan showed significantly reduced triglyceride, total cholesterol and low\u2010density lipoprotein levels in the plasma. Liver steatosis induced by the HFD improved in the fucoidan\u2010supplemented group. Furthermore, fucoidan affected the down\u2010regulation expression patterns of epididymal adipose tissue genes such as peroxisome proliferator\u2010activated receptor \u03b3, adipose\u2010specific fatty acid binding protein and acetyl CoA carboxylase. Therefore, fucoidan may be considered for use in improving obesity. Copyright \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.4965","type":"journal-article","created":{"date-parts":[[2013,4,12]],"date-time":"2013-04-12T04:28:38Z","timestamp":1365740918000},"page":"137-143","source":"Crossref","is-referenced-by-count":114,"title":["Fucoidan Prevents High\u2010Fat Diet\u2010Induced Obesity in Animals by Suppression of Fat Accumulation"],"prefix":"10.1002","volume":"28","author":[{"given":"Mi\u2010Ja","family":"Kim","sequence":"first","affiliation":[{"name":"The Institute of Life Science Sungkyunkwan University  300 Cheoncheon\u2010dong, Jangan\u2010Gu, Gyeonggi\u2010do 440\u2010746 Suwon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Jeon","sequence":"additional","affiliation":[{"name":"Haewon Biotech, Inc.  75\u20101, Hongji\u2010Dong, Jongno\u2010Gu Seoul 110\u2010020 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Sil","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Foodservice Management and Nutrition Sangmyung University  7 Hongji\u2010dong, Jongno\u2010Gu Seoul 110\u2010743 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,4,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/md9102106"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000033090.81345.E6"},{"key":"e_1_2_6_4_1","first-page":"155","article-title":"Studies on the chemistry of blood coagulation II. 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