{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T13:43:04Z","timestamp":1782135784107,"version":"3.54.5"},"reference-count":9,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T00:00:00Z","timestamp":1365033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:p>Inflammatory bowel disease is an urgent public health problem with a high incidence in developed countries. Alterations of lifestyle or dietary interventions may attenuate the disease progression and increase the efficacy of current therapies. Here we tested the effect of chronic supplementation with a mineral extract from red marine algae \u2013 rich in calcium (34%), magnesium, phosphorus, selenium and other trace minerals \u2013 in a clinically relevant model of spontaneous enterocolitis, interleukin (IL)\u201010<jats:sup>\u2010\/\u2010<\/jats:sup> mice. The mineral extract was administered in the drinking water of <jats:italic>Il10<\/jats:italic><jats:sup>\u2010\/\u2010<\/jats:sup> mice on C57BL\/6\u2009J and BALB\/c strain backgrounds for 25\u2009weeks commencing from 3 to 4\u2009weeks of age. The mineral extract ameliorated the spontaneous development of colitis and severity of disease in <jats:italic>Il10<\/jats:italic><jats:sup>\u2010\/\u2010<\/jats:sup> mice on a C57BL\/6\u2009J background. Mineral extract\u2010treated <jats:italic>Il10<\/jats:italic><jats:sup>\u2010\/\u2010<\/jats:sup> C57BL\/6\u2009J strain mice had significantly reduced mortality, circulating levels of serum Amyloid A and reduced colonic tissue damage. In contrast, comparable treatment of <jats:italic>Il10<\/jats:italic><jats:sup>\u2010\/\u2010<\/jats:sup> mice on a BALB\/c background with the mineral extract did not alter the course of colitis. These data demonstrate that chronic supplementation with a natural mineral extract selectively ameliorates spontaneous mild\u2013moderate colitis in <jats:italic>Il10<\/jats:italic><jats:sup>\u2010\/\u2010<\/jats:sup> mice on a C57BL\/6\u2009J, but does not attenuate more moderate\u2013severe colitis in BALB\/c strain animals. Copyright \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.4989","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T07:47:03Z","timestamp":1365061623000},"page":"300-304","source":"Crossref","is-referenced-by-count":28,"title":["A Mineral Extract from red Algae Ameliorates Chronic Spontaneous Colitis in IL\u201010 Deficient Mice in a Mouse Strain Dependent Manner"],"prefix":"10.1002","volume":"28","author":[{"given":"Gabriella","family":"Aviello","sequence":"first","affiliation":[{"name":"School of Medicine, Trinity Biomedical Sciences Institute Trinity College Dublin  Dublin 2 Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Amu","sequence":"additional","affiliation":[{"name":"School of Medicine, Trinity Biomedical Sciences Institute Trinity College Dublin  Dublin 2 Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean P.","family":"Saunders","sequence":"additional","affiliation":[{"name":"School of Medicine, Trinity Biomedical Sciences Institute Trinity College Dublin  Dublin 2 Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Padraic G.","family":"Fallon","sequence":"additional","affiliation":[{"name":"School of Medicine, Trinity Biomedical Sciences Institute Trinity College Dublin  Dublin 2 Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,4,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-010-9340-9"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118861"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i29.3814"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20111453"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2011.133"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-7-9"},{"key":"e_1_2_6_8_1","first-page":"90","article-title":"Inflammatory mediators and acute phase proteins in patients with Crohn's disease and ulcerative colitis","volume":"44","author":"Niederau C","year":"1997","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901970"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0050198"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.4989","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.4989","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T00:53:50Z","timestamp":1696467230000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.4989"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,4]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1002\/ptr.4989"],"URL":"https:\/\/doi.org\/10.1002\/ptr.4989","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,4]]}}}