{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T06:07:29Z","timestamp":1764828449866},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,4,18]],"date-time":"2013-04-18T00:00:00Z","timestamp":1366243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:p>A commercial resin\u2010based pine oil (PO) derived from <jats:italic>Pinus palustris<\/jats:italic> and <jats:italic>Pinus elliottii<\/jats:italic> was the major focus of this investigation. Extracts of pine resins, needles, and bark are folk medicines commonly used to treat skin ailments, including burns. The American Burn Association estimates that 500,000 people with burn injuries receive medical treatment each year; one\u2010half of US burn victims are children, most with scald burns. This systematic study was initiated as follow\u2010up to personal anecdotal evidence acquired over more than 10\u2009years by MH Bhattacharyya regarding PO's efficacy for treating burns. The results demonstrate that PO counteracted dermal inflammation in both a mouse ear model of contact irritant\u2010induced dermal inflammation and a second degree scald burn to the mouse paw. Furthermore, PO significantly counteracted the tactile allodynia and soft tissue injury caused by the scald burn. In mouse dorsal root ganglion neuronal cultures, PO added to the medium blocked adenosine triphosphate\u2010activated, but not capsaicin\u2010activated, pain pathways, demonstrating specificity. These results together support the hypothesis that a pine\u2010oil\u2010based treatment can be developed to provide effective in\u2010home care for second degree burns. Copyright \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.4991","type":"journal-article","created":{"date-parts":[[2013,4,18]],"date-time":"2013-04-18T05:47:37Z","timestamp":1366264057000},"page":"252-260","source":"Crossref","is-referenced-by-count":11,"title":["Pine Oil Effects on Chemical and Thermal Injury in Mice and Cultured Mouse Dorsal Root Ganglion Neurons"],"prefix":"10.1002","volume":"28","author":[{"given":"S. P.","family":"Clark","sequence":"first","affiliation":[{"name":"Medical College of Georgia Georgia Regents University  Augusta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. 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