{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:45:28Z","timestamp":1790181928334,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,4,26]],"date-time":"2013-04-26T00:00:00Z","timestamp":1366934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:p>Rhizoma Dioscoreae Nipponicae (RDN) is a widely used traditional Chinese herb, which is used to treat arthroncus, arthrodynia and arthritis. As is known to us, inflammatory mechanisms have played an important role in the occurrence, course and prognosis of gouty arthritis (GA). The aim of this study was to determine the characteristic expressed proteins of synovium in GA rat and synovial cell. The rat model of GA was induced by monosodium urate (MSU) crystal. Tissue samples were assayed by immunohistochemical method. The effects of RDN on Stromal cell\u2010derived factor 1 (SDF\u20101), CXCR 4 and p38 mitogen\u2010activated protein kinase (MAPK) were investigated in MSU crystal\u2010induced rat. The levels of SDF\u20101 and mitogen\u2010activated kinase kinase (MKK) 3\/6 were measured by Western Blot in interleukin\u20101\u03b2 (IL\u20101\u03b2) incubated fibroblast\u2010like synoviocytes (FLS). A significant increase in the levels of SDF\u20101, CXCR 4 and p38 MAPK were observed in MSU crystal\u2010induced rat. The increased SDF\u20101 and MKK 3\/6 levels were observed in IL\u20101\u03b2 incubated FLS. With the treatment of RDN, the above changes were reverted back to near normal levels. RDN might have some therapeutic effects on GA through SDF\u20101\/CXCR 4 and p38 MAPK pathway, and dioscin may be the active compound in RDN to exert therapeutic effect on GA. Copyright \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.4997","type":"journal-article","created":{"date-parts":[[2013,4,26]],"date-time":"2013-04-26T07:21:34Z","timestamp":1366960894000},"page":"280-288","source":"Crossref","is-referenced-by-count":35,"title":["Therapeutic Effect of Rhizoma Dioscoreae Nipponicae on Gouty Arthritis Based on the SDF\u20101\/CXCR 4 and p38 MAPK Pathway: An <i>In Vivo<\/i> and <i>In Vitro<\/i> Study"],"prefix":"10.1002","volume":"28","author":[{"given":"Fang","family":"Lu","sequence":"first","affiliation":[{"name":"Chinese Medicine Toxicological Laboratory, Institute of Traditional Chinese Medicine Heilongjiang University of Chinese Medicine  Harbin 150040 PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Liu","sequence":"additional","affiliation":[{"name":"Chinese Medicine Toxicological Laboratory, Institute of Traditional Chinese Medicine Heilongjiang University of Chinese Medicine  Harbin 150040 PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u2010hua","family":"Yu","sequence":"additional","affiliation":[{"name":"Chinese Medicine Toxicological Laboratory, Institute of Traditional Chinese Medicine Heilongjiang University of Chinese Medicine  Harbin 150040 PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu\u2010zhao","family":"Li","sequence":"additional","affiliation":[{"name":"Chinese Medicine Toxicological Laboratory, Institute of Traditional Chinese Medicine Heilongjiang University of Chinese Medicine  Harbin 150040 PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Chinese Medicine Toxicological Laboratory, Institute of Traditional Chinese Medicine Heilongjiang University of Chinese Medicine  Harbin 150040 PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu\u2010min","family":"Liu","sequence":"additional","affiliation":[{"name":"Chinese Medicine Toxicological Laboratory, Institute of Traditional Chinese Medicine Heilongjiang University of Chinese Medicine  Harbin 150040 PR China"},{"name":"Drug Safety Evaluation Center Heilongjiang University of Chinese Medicine  Harbin 150040 PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,4,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/382829a0"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(03)00063-9"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1107303"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63108-2"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2011.12.016"},{"key":"e_1_2_8_7_1","unstructured":"ChPC.2010.Dioscoreae nipponicae rhizoma (Chuanshanlong). 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