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Rats were orally administered ACH (30\u2009mg\/kg\/day) with or without PYC (20\u2009mg\/kg\/day) for 7\u2009days. Administration of ACH significantly decreased sperm motility. \u03b1\u2010Chlorohydrin also caused histopathological alterations and apoptotic changes in caput epididymides. An increased malondialdehyde concentration and decreased glutathione content, as well as catalase and glutathione peroxidase activities were also found. In contrast, PYC treatment significantly prevented ACH\u2010induced spermatotoxicity, including decreased sperm motility, histopathological lesions, and apoptotic changes in the caput epididymis. Pycnogenol\u00ae also had an antioxidant benefit by decreasing malondialdehyde and increasing levels of the antioxidant glutathione and the activities of the antioxidant enzymes catalase and peroxidase in epididymal tissues. These results indicate that PYC treatment attenuated ACH\u2010induced spermatotoxicity through antioxidant and antiapoptotic effects. 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