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Pycnogenol is a French maritime pine bark extract produced from the outer bark of <jats:italic>Pinus pinaster<\/jats:italic> Ait. subsp. <jats:italic>atlantica<\/jats:italic>. Its strong antioxidant, anti\u2010inflammatory and vasodilator activities, antithrombotic effects and collagen stabilizing properties make it uniquely able to target the multi facet pathophysiology of CVI and related venous disorders. Clinical studies have shown that it can reduce oedema of the legs in CVI, reduce the incidence of deep venous thrombosis during long haul flights and enhance the healing of venous ulcers and haemorrhoidal episodes by topical application and\/or oral administration. This review highlights clinical research findings on the safety, compliance and efficacy of Pycnogenol, including its use in combination products. 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