{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:55:38Z","timestamp":1786978538266,"version":"build-2736575974"},"reference-count":132,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,7,4]],"date-time":"2013-07-04T00:00:00Z","timestamp":1372896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:p>Traditional Chinese medicines have been recommended for bone regeneration and repair for thousands of years. Currently, the Herba Epimedii and its multi\u2010component formulation are the attractive native herbs for the treatment of osteoporosis. Icariin, a typical flavonol glycoside, is considered to be the main active ingredient of the Herba Epimedii from which icariin has been successfully extracted. Most interestingly, it has been reported that icariin can be delivered locally by biomaterials and that it has an osteoinductive potential for bone tissue engineering. This review focuses on the performance of icariin in bone tissue engineering and on blending the information from icariin with the current knowledge relevant to molecular mechanisms and signal pathways. The osteoinductive potential of icariin could be attributed to its multiple functions in the musculoskeletal system which is involved in the regulation of multiple signaling pathways in anti\u2010osteoporosis, osteogenesis, anti\u2010osteoclastogenesis, chondrogenesis, angiogenesis, and anti\u2010inflammation. The osteoinductive potential and the low price of icariin make it a very attractive candidate as a substitute of osteoinductive protein\u2013bone morphogenetic proteins (BMPs), or as a promoter for enhancing the therapeutic effects of BMPs. However, the effectiveness of the local delivery of icariin needs to be investigated further. Copyright \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.5027","type":"journal-article","created":{"date-parts":[[2013,7,4]],"date-time":"2013-07-04T05:22:05Z","timestamp":1372915325000},"page":"498-509","source":"Crossref","is-referenced-by-count":70,"title":["Icariin: Does It Have An Osteoinductive Potential for Bone Tissue Engineering?"],"prefix":"10.1002","volume":"28","author":[{"given":"Xin","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Stomatology Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tie","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Oral Implantology and Prosthetic Dentistry, Academic Centre for Dentistry Amsterdam (ACTA), Research Institute MOVE University of Amsterdam and VU University Amsterdam  Gustav Mahlerlaan 3004 1081 LA Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanliang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Dentistry Shanghai East Hospital Affiliated to Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Wismeijer","sequence":"additional","affiliation":[{"name":"Department of Oral Implantology and Prosthetic Dentistry, Academic Centre for Dentistry Amsterdam (ACTA), Research Institute MOVE University of Amsterdam and VU University Amsterdam  Gustav Mahlerlaan 3004 1081 LA Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuelian","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Oral Implantology and Prosthetic Dentistry, Academic Centre for Dentistry Amsterdam (ACTA), Research Institute MOVE University of Amsterdam and VU University Amsterdam  Gustav Mahlerlaan 3004 1081 LA Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,7,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200205000-00003"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00113-006-1079-4"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2004.01.011"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200002000-00003"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/8792"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.2741\/E453"},{"key":"e_1_2_11_8_1","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.2106\/00004623-200407000-00033","article-title":"What's new in spine surgery","volume":"86","author":"Bridwell KH","year":"2004","journal-title":"J Bone Joint Surg Am"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2004.10.1757"},{"key":"e_1_2_11_10_1","first-page":"435","article-title":"Icariin stimulates MC3T3\u2010E1 cell proliferation and differentiation through up\u2010regulation of bone morphogenetic protein\u20102","volume":"29","author":"Cao H","year":"2012","journal-title":"Int J Mol Med"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/ID.0b013e3181dec322"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X04002004"},{"issue":"12","key":"e_1_2_11_13_1","first-page":"939","article-title":"Icariin, a flavonoid from the herb Epimedium enhances the osteogenic differentiation of rat primary bone marrow stromal cells","volume":"60","author":"Chen KM","year":"2005","journal-title":"Pharmazie"},{"key":"e_1_2_11_14_1","first-page":"388","article-title":"Icariin inhibits the osteoclast formation induced by RANKL and macrophage\u2010colony stimulating factor in mouse bone marrow culture","volume":"62","author":"Chen KM","year":"2007","journal-title":"Pharmazie"},{"key":"e_1_2_11_15_1","first-page":"785","article-title":"Icariin enhances the osteogenic differentiation of bone marrow stromal cells but has no effects on the differentiation of newborn calvarial osteoblasts of rats","volume":"62","author":"Chen KM","year":"2007","journal-title":"Pharmazie"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.33.1307"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.09.001"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt958"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1003-6326(11)61035-2"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2007.03.003"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2004.00986.x"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.11.050"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199810001-00003"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-011-4491-4"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules161210123"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1159\/000075031"},{"key":"e_1_2_11_27_1","first-page":"1","article-title":"Bone morphogenetic protein (BMP) for fracture healing in adults","volume":"6","author":"Garrison KR","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.81B4.9311"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2011.03.021"},{"key":"e_1_2_11_30_1","first-page":"585","article-title":"Experimental study on the mechanism of icariin improving human osteoblasts proliferation and the expression of OPG protein","volume":"24","author":"Guo HL","year":"2011","journal-title":"Beijing Da Xue Xue Bao"},{"key":"e_1_2_11_31_1","first-page":"669","article-title":"Effect of icariin on the mRNA expressions of Cbfalpha1, BMP2, BMP4 in rat osteoblasts","volume":"41","author":"He W","year":"2009","journal-title":"Beijing Da Xue Xue Bao"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002239900329"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2010.04.003"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2009.08.007"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2007.07.015"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11434-007-0121-4"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/pca.1018"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2004.06.005"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1081\/IPH-200026879"},{"key":"e_1_2_11_40_1","first-page":"525","article-title":"Effect of icariin on hypoxia induced vascular endothelial cells injury","volume":"25","author":"Ji RR","year":"2005","journal-title":"Chin J Integ Tradit Western Med"},{"key":"e_1_2_11_41_1","first-page":"1604","article-title":"Study on extraction process for the icariin of hugu capsule with ultrasonic technology","volume":"34","author":"Jia HH","year":"2011","journal-title":"J Chin Med Mater"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02980054"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X05002643"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3302298"},{"key":"e_1_2_11_45_1","first-page":"61","article-title":"The Negative Effect of Combining rhBMP\u20102 and Bio\u2010Oss on Bone Formation for Maxillary Sinus Augmentation","volume":"32","author":"Kao DW","year":"2012","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02980200"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2010.04.049"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.200902589"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02973876"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2012.08.009"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/chromsci\/47.5.337"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.3514"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2012.1079"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0083-6729(01)62001-6"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200206000-00022"},{"key":"e_1_2_11_56_1","first-page":"431","article-title":"Effect of jiangu granule on quality of bone in model rats with osteoporosis induced by ovariectomy","volume":"24","author":"Lin YP","year":"2004","journal-title":"Chin J Integ Tradit Western Med"},{"key":"e_1_2_11_57_1","first-page":"1784","article-title":"Icariin associated with exercise therapy is an effective treatment for postmenopausal osteoporosis","volume":"125","author":"Liu M","year":"2012","journal-title":"Chin Med J"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2009.10.020"},{"key":"e_1_2_11_59_1","first-page":"500","article-title":"Effects of icariin and icariside II on eNOS expression and NOS activity in porcine aorta endothelial cells","volume":"43","author":"Liu T","year":"2011","journal-title":"Beijing Da Xue Xue Bao"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2010.0115.focus"},{"key":"e_1_2_11_61_1","first-page":"1076","article-title":"Effect of Herba Epimedii Flavone on expression of OPG and RANKL in rat osteoblasts","volume":"28","author":"Liu Y","year":"2005","journal-title":"J Chin Med Mater"},{"key":"e_1_2_11_62_1","first-page":"487","article-title":"Effect of Herba Epimedii flavone on the osteoblasts metabolism in vitro","volume":"31","author":"Liu YH","year":"2006","journal-title":"China J Chin Mater Med"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2007.04647.x"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.23007"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200103010-00009"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2004.03.007"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1080\/13880200590903435"},{"key":"e_1_2_11_68_1","first-page":"2240","article-title":"Comparative study on effect of icariin and genistein on proliferation and mineralization of osteoblasts in vitro","volume":"36","author":"Ming L","year":"2011","journal-title":"China J Chin Mater Med"},{"key":"e_1_2_11_69_1","first-page":"132","article-title":"Clinical observation on 96 cases of primary osteoporosis treated with kidney\u2010tonifying and bone\u2010strengthening mixture","volume":"25","author":"Mingyue W","year":"2005","journal-title":"J Tradit Chin Med"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00593.x"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2010.01939.x"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2008.12.006"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-003-0431-9"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2184.2004.00303.x"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1097\/ID.0b013e3182386cbc"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-2358.2011.00470.x"},{"key":"e_1_2_11_77_1","first-page":"466","article-title":"A review on research of raw material and cut crude drug of Herba epimedii in last ten years","volume":"32","author":"Pei LK","year":"2007","journal-title":"China J Chin Mater Med"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.01.047"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2030"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.53.87"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2012.03.053"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2008.04.009"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03026324"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2005.04.018"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2007.05.003"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1430139"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-1383(09)70010-5"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.E.01006"},{"key":"e_1_2_11_89_1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1097\/00003086-198702000-00008","article-title":"Treatment of forearm bone fractures by an integrated method of traditional Chinese and Western medicine","volume":"215","author":"Shang TY","year":"1987","journal-title":"Clin Orthop Relat Res"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-1383(09)70009-9"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2003.08.004"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199810001-00024"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01268.x"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.150.3698.893"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-18343"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2012.06.001"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01807.x"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2005.02.023"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2010.10.015"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.22203\/eCM.v019a04"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.3109\/08923971003725144"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2011.10.015"},{"key":"e_1_2_11_103_1","first-page":"330","article-title":"Effects of icariin on inflammation model stimulated by lipopolysaccharide in vitro and in vivo","volume":"29","author":"Wu JF","year":"2009","journal-title":"Chin J Integ Tradit Western Med"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11434-009-0250-z"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02896172"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecam\/neh101"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.28.1879"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2010.05.012"},{"key":"e_1_2_11_109_1","first-page":"224","article-title":"Effects of Chinese herbal medicine on bone structure and function","volume":"24","author":"Xu H","year":"2004","journal-title":"J Tradit Chin Med"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2007.03.002"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/490843"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/241416"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/241416"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-3659(99)00129-7"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2012.11.031"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.2011.01388.x"},{"key":"e_1_2_11_117_1","first-page":"289","article-title":"Effects of Epimedium pubescens epimedium on proliferation and differentiation of human osteoblasts","volume":"30","author":"Yin XX","year":"2005","journal-title":"China J Chin Mat Med (in Chinese)"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1097\/00029330-200702010-00006"},{"key":"e_1_2_11_119_1","first-page":"917","article-title":"Effects of icariin on the proliferation, differentiation and maturation of rat calvarial osteoblasts in vitro","volume":"34","author":"Zhai YK","year":"2011","journal-title":"J Chin Med Mater"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2012.06.033"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2007.04.002"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11434-007-0485-5"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.070405"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultsonch.2007.09.002"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-011-8987-z"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.3733"},{"key":"e_1_2_11_127_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-010-4198-y"},{"key":"e_1_2_11_128_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M511039200"},{"key":"e_1_2_11_129_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2009.0165"},{"key":"e_1_2_11_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.02.054"},{"key":"e_1_2_11_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2012.04.006"},{"key":"e_1_2_11_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2011.01.007"},{"key":"e_1_2_11_133_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-011-1577-2"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.5027","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.5027","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.5027","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T01:06:46Z","timestamp":1710896806000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.5027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,4]]},"references-count":132,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1002\/ptr.5027"],"URL":"https:\/\/doi.org\/10.1002\/ptr.5027","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,4]]}}}