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Methods were according to the Cochrane Handbook and meta\u2010analyses used RevMan 5.1. Nine studies met the inclusion\/exclusion criteria. The comparisons were with placebo and\/or anti\u2010psoriatic pharmacotherapy (APP) with two studies having three arms. The pooled meta\u2010analysis data indicated the topical herbal formulae improved overall clinical efficacy (defined as 50% improvement or greater) when compared with: topical placebo (plus oral herbal co\u2010intervention); topical APP alone; and topical APP (plus pharmaceutical co\u2010intervention). Improvement was evident in Modified Psoriasis Area and Severity Index (PASI) score when topical herbal formula was compared to placebo (plus oral herbal co\u2010intervention). No serious adverse events were reported. The most commonly used herbs were <jats:italic>Sophora flavescens<\/jats:italic> root and <jats:italic>Lithospermum erythrorhizon<\/jats:italic> root. Experimental studies reported that these herbs and\/or their constituents have anti\u2010inflammatory, anti\u2010proliferative, anti\u2010angiogenic, and tissue repair actions. These actions may at least partially explain the apparent benefits of the topical multi\u2010herbal formulations in psoriasis. Copyright \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.5028","type":"journal-article","created":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T03:16:20Z","timestamp":1372734980000},"page":"480-497","source":"Crossref","is-referenced-by-count":38,"title":["Topical Herbal Formulae in the Management of Psoriasis: Systematic Review with Meta\u2010Analysis of Clinical Studies and Investigation of the Pharmacological Actions of the Main Herbs"],"prefix":"10.1002","volume":"28","author":[{"given":"Shiqiang","family":"Deng","sequence":"first","affiliation":[{"name":"School of Health Sciences, and Traditional and Complementary Medicine Research Program, Health Innovations Research Institute RMIT University  Bundoora VIC 3083 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian H.","family":"May","sequence":"additional","affiliation":[{"name":"School of Health Sciences, and Traditional and Complementary Medicine Research Program, Health Innovations Research Institute RMIT University  Bundoora VIC 3083 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony L.","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Health Sciences, and Traditional and Complementary Medicine Research Program, Health Innovations Research Institute RMIT University  Bundoora VIC 3083 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuanjian","family":"Lu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Academy of Chinese Medical Sciences &amp; Guangdong Provincial Hospital of Chinese Medicine  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlie C. 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