{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T18:52:50Z","timestamp":1786560770549,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,10,22]],"date-time":"2013-10-22T00:00:00Z","timestamp":1382400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:p>The present study is initially intended to evaluate antioxidant and \u03b2\u2010hydroxy\u2010\u03b2\u2010methylglutaryl\u2010CoA reductase (HMGR) inhibitory property of <jats:italic>Ficus virens<\/jats:italic> Ait., first by <jats:italic>in vitro<\/jats:italic> analyses followed by a corroboratory molecular informatics study. Our results show that of all the sequentially extracted fraction of <jats:italic>F<\/jats:italic>. <jats:italic>virens<\/jats:italic> bark and leaves extract, <jats:italic>F<\/jats:italic>. <jats:italic>virens<\/jats:italic> bark methanol extract exhibits strong radical scavenging, antioxidant and oxidative DNA damage protective activity, which is well correlated with its total phenolic content. In addition, <jats:italic>F<\/jats:italic>. <jats:italic>virens<\/jats:italic> bark methanol extract, which is non\u2010cytotoxic, significantly and non\u2010covalently inhibit the HMGR activity (IC<jats:sub>50<\/jats:sub>\u2009=\u20093.45\u2009\u00b1\u20090.45\u2009\u00b5g\/ml) in comparison with other extracts. The mechanistic aspect of this inhibition activity is authenticated by molecular docking study of bioactive compounds as revealed from gas chromatography\u2013mass spectrometry data, with HMGR. The analysis for the first time indicates that quinic acid (\u0394G: \u22128.11\u2009kcal\/mol) and paravastatin (\u0394G: \u22128.22\u2009kcal\/mol) exhibit almost same binding energy, while other compounds also showed good binding energy, suggesting that quinic acid alone or in combination with other major bioactive compound is probably responsible for HMGR inhibitory property of the extract and plausibly can be used in <jats:italic>in vivo<\/jats:italic> system for the management, prevention, and alleviation of hypercholesterolemia as well as hypercholesterolemia\u2010induced oxidative stress. Copyright \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.5077","type":"journal-article","created":{"date-parts":[[2013,10,22]],"date-time":"2013-10-22T13:18:52Z","timestamp":1382447932000},"page":"899-908","source":"Crossref","is-referenced-by-count":25,"title":["An <i>In Vitro<\/i> and Molecular Informatics Study to Evaluate the Antioxidative and \u03b2\u2010hydroxy\u2010\u03b2\u2010methylglutaryl\u2010CoA Reductase Inhibitory Property of <i>Ficus virens<\/i> Ait"],"prefix":"10.1002","volume":"28","author":[{"given":"Danish","family":"Iqbal","sequence":"first","affiliation":[{"name":"Clinical Biochemistry and Natural Product Research Lab, Department of Biosciences Integral University  Lucknow 226026 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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