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In view of the critical need to augment the current drug regime, we have investigated therapeutic potential of five quinonoids, viz. emodin, diospyrin, plumbagin, menadione and thymoquinone, derived from natural products. The antimicrobial activity of quinonoids was evaluated against a broad panel of multi\u2010drug and extensively drug\u2010resistant tuberculosis (M\/XDR\u2010TB) strains, rapid growing mycobacteria and other bacterial isolates, some of which were producers of \u03b2\u2010lactamase, Extended\u2010spectrum \u03b2\u2010lactamase (ESBL), AmpC \u03b2\u2010lactamase, metallo\u2010beta\u2010lactamase (MBL) enzymes, as well as their drug\u2010sensitive ATCC counterparts. All the tested quinones exhibited antimycobacterial and broad spectrum antibacterial activity, particularly against <jats:italic>M. tuberculosis<\/jats:italic> (lowest MIC 0.25\u2009\u00b5g\/mL) and Gram\u2010positive bacteria (lowest MIC &lt;4\u2009\u00b5g\/mL) of clinical origin. The order of antitubercular activity of the tested quinonoids was plumbagin\u2009&gt;\u2009emodin\u2009~\u2009menadione\u2009~\u2009thymoquinone\u2009&gt;\u2009diospyrin, whereas their antibacterial efficacy was plumbagin\u2009&gt;\u2009menadione\u2009~\u2009thymoquinone\u2009&gt;\u2009diospyrin\u2009&gt;\u2009emodin. Furthermore, this is the first evaluation performed on these quinonoids against a broad panel of drug\u2010resistant and drug\u2010sensitive clinical isolates, to the best of our knowledge. Copyright \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.5090","type":"journal-article","created":{"date-parts":[[2013,12,7]],"date-time":"2013-12-07T04:11:14Z","timestamp":1386389474000},"page":"1014-1021","source":"Crossref","is-referenced-by-count":88,"title":["Antitubercular and Antibacterial Activity of Quinonoid Natural Products Against Multi\u2010Drug Resistant Clinical Isolates"],"prefix":"10.1002","volume":"28","author":[{"given":"Diganta","family":"Dey","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Technology Jadavpur University  Kolkata 700032 India"},{"name":"Department of Microbiology Ashok Laboratory Clinical Testing Centre Private Limited  Kolkata 700068 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ratnamala","family":"Ray","sequence":"additional","affiliation":[{"name":"Department of Microbiology Ashok Laboratory Clinical Testing Centre Private Limited  Kolkata 700068 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banasri","family":"Hazra","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology Jadavpur University  Kolkata 700032 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1573(200003)14:2<112::AID-PTR488>3.0.CO;2-T"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1752"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.5.1873-1874.2002"},{"key":"e_1_2_7_5_1","volume-title":"Performance standards for antimicrobial susceptibility testing; twenty\u2010third informational supplement (Document M100\u2010S23)","author":"Clinical and Laboratory Standards Institute","year":"2013"},{"key":"e_1_2_7_6_1","volume-title":"Mackie and McCartney Practical Medical Microbiology","author":"Collee JG","year":"1996"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.12.4.564"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2012.09.001"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2741\/4024"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2004.08.007"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.867"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.10.0367"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.03.018"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.419069"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-0711-10-29"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(10)70143-2"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2650090508"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg068"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(97)01020-0"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0285.2010.00987.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1420"},{"key":"e_1_2_7_22_1","first-page":"01","article-title":"Antimycobacterial activity of diospyrin and its derivatives against Mycobacterium aurum","volume":"2","author":"Mukanganyama S","year":"2012","journal-title":"Res Pharm"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/1099-1573(200008)14:5<303::AID-PTR712>3.0.CO;2-N"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8755-9668(86)80030-8"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00425-002-0874-6"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2005.06.008"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.5740\/jaoacint.12-010"},{"key":"e_1_2_7_28_1","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1128\/jcm.28.7.1608-1612.1990","article-title":"BacT\/Alert: an automated colorimetric microbial detection system","volume":"28","author":"Thorpe TC","year":"1990","journal-title":"J Clin Micro"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2004.07.015"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2009.09.023"},{"key":"e_1_2_7_31_1","unstructured":"World Health Organization.2010.Multidrug and extensively drug\u2010resistant TB (M\/XDR\u2010TB): global report on surveillance and response (WHO\/HTM\/TB\/2010.3.). 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