{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:21:33Z","timestamp":1791354093007,"version":"4.3.1"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,3,12]],"date-time":"2014-03-12T00:00:00Z","timestamp":1394582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:p>Flavonoids are compounds responsible for several organoleptic characteristics of plant\u2010derived foods. They are also bioactive compounds with antiinflammatory role. Different mechanisms for this activity have been reported, but their effects on cell migration are not fully understood. In the present study, the role of flavonoids on leukocyte migration <jats:italic>in vivo<\/jats:italic> was investigated, using the carrageenan\u2010induced pleurisy model and intravital microscopy in rats. It was found that quercetin (1), rutin (2), flavone (5), apigenin (6) and flavonol (7) reduced cell migration to the pleural cavity and inhibited rolling, adhesion and transmigration. Additionally, flow cytometry assays showed that the <jats:italic>in vitro<\/jats:italic> treatment with all compounds (15\u201360\u2009\u00b5<jats:sc>m<\/jats:sc>) did not cause cell death and 1 inhibited the cleavage of <jats:sc>L<\/jats:sc>\u2010selectin and the \u03b22\u2010integrin expression, whereas 2 and 7 only inhibited the \u03b22\u2010integrin expression. Together, data herein presented clearly show the ability of flavonoids to inhibit <jats:italic>in vivo<\/jats:italic> neutrophil influx into inflamed tissue, by acting in different mechanisms of neutrophil migration. Copyright \u00a9 2014 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.5144","type":"journal-article","created":{"date-parts":[[2014,3,12]],"date-time":"2014-03-12T09:40:07Z","timestamp":1394617207000},"page":"1406-1411","source":"Crossref","is-referenced-by-count":15,"title":["Beyond Organoleptic Characteristics: The Pharmacological Potential of Flavonoids and their Role in Leukocyte Migration and in <scp>L<\/scp>\u2010Selectin and \u03b22\u2010Integrin Expression During Inflammation"],"prefix":"10.1002","volume":"28","author":[{"given":"Edna Sayuri","family":"Suyenaga","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, Faculdade de Farm\u00e1cia Universidade Federal do Rio Grande do Sul  Porto Alegre RS Brazil"},{"name":"Curso de Ci\u00eancias Farmac\u00eauticas, Instituto de Ci\u00eancias da Sa\u00fade Universidade FEEVALE  Novo Hamburgo RS 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