{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T13:06:51Z","timestamp":1777295211722,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,5,2]],"date-time":"2014-05-02T00:00:00Z","timestamp":1398988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:p>Evidences are accumulating that extract of <jats:italic>Acanthopanax senticosus<\/jats:italic> Harms (ASH; syn <jats:italic>Eleutherococcus senticosus<\/jats:italic> [Rupr. &amp; Maxim.] Maxim), a shrub native to Northeastern Asia, has antiinflammatory effects. In this study, we examined prophylactic and therapeutic effects of ASH extract (ASHE) on rheumatoid arthritis using collagen\u2010induced arthritis (CIA) mouse model. <jats:italic>Acanthopanax senticosus<\/jats:italic> Harms extract was administered before the onset of arthritis in the prophylaxis model. In the therapeutic model, ASHE was administered after the onset of arthritis with or without anti\u2010TNF\u2010\u03b1 antibody. The ASHE treatment showed efficacy before onset of CIA but there was no effect after CIA was established. The ASHE treatment delayed the onset and decreased severity of CIA. <jats:italic>In vitro<\/jats:italic> examinations showed that ASHE is an antioxidant and that ASHE suppresses TNF\u2010\u03b1 and interleukin\u20106 production in human peripheral blood mononuclear cells. The combination therapy with ASHE and anti\u2010TNF\u2010\u03b1 antibody reduced the severity of arthritis compared with anti\u2010TNF\u2010\u03b1 antibody alone. The present study shows that ASHE has prophylactic effect against CIA and support therapeutic effect of anti\u2010TNF\u2010\u03b1 antibody. \u00a9 2014 The Authors. <jats:italic>Phytotherapy Research<\/jats:italic> published by John Wiley &amp; Sons Ltd.<\/jats:p>","DOI":"10.1002\/ptr.5157","type":"journal-article","created":{"date-parts":[[2014,5,3]],"date-time":"2014-05-03T00:58:41Z","timestamp":1399078721000},"page":"1513-1519","source":"Crossref","is-referenced-by-count":16,"title":["Prophylactic and Therapeutic Effects of <scp><i>Acanthopanax senticosus<\/i><\/scp> Harms Extract on Murine Collagen\u2010induced Arthritis"],"prefix":"10.1002","volume":"28","author":[{"given":"Yusuke","family":"Takahashi","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Medicine Sapporo Medical University School of Medicine  Sapporo 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