{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T23:41:23Z","timestamp":1767138083103,"version":"build-2238731810"},"reference-count":14,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,5,12]],"date-time":"2014-05-12T00:00:00Z","timestamp":1399852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Fund of China","doi-asserted-by":"crossref","award":["81102773"],"award-info":[{"award-number":["81102773"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Outstanding Youth Program of Shanghai Medical System","award":["XYQ2013100"],"award-info":[{"award-number":["XYQ2013100"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:p>\n                    Our study aims to ascertain the antiinflammatory activity of\n                    <jats:italic>Veronicastrum axillare<\/jats:italic>\n                    and characterize the bioactive constituents. Antiinflammatory activity of the total extract and different fractions from\n                    <jats:italic>V. axillare<\/jats:italic>\n                    was investigated by employing the xylene\u2010induced mouse ear edema model. As a result, the ethyl acetate (EtOAc) fraction showed the highest antiinflammatory activity\n                    <jats:italic>in vivo<\/jats:italic>\n                    . From the EtOAc fraction and the inactive dichloromethane fraction, a total of five new compounds, axillasides A\u2013C and axillactones A and B, together with four known compounds, procumboside A, buergeriside C\n                    <jats:sub>1<\/jats:sub>\n                    , indole\u20103\u2010carboxylic acid and apigenin, were isolated and identified. Their structures were elucidated on the basis of spectroscopic analysis and by comparison of their nuclear magnetic resonance data with those reported in the literature. Procumboside A, a major constituent in EtOAc fraction, showed significant antiinflammatory activity\n                    <jats:italic>in vivo<\/jats:italic>\n                    . Further studies revealed that procumboside A was a potent COX\u20102 inhibitor, significantly reducing the COX\u20102 protein level in lipopolysaccharide\u2010stimulated RAW 264.7 macrophages. Copyright \u00a9 2014 John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/ptr.5168","type":"journal-article","created":{"date-parts":[[2014,5,12]],"date-time":"2014-05-12T05:38:15Z","timestamp":1399873095000},"page":"1561-1566","source":"Crossref","is-referenced-by-count":8,"title":["Antiinflammatory Effects and Chemical Constituents of\n                    <i>Veronicastrum axillare<\/i>"],"prefix":"10.1002","volume":"28","author":[{"given":"Cheng\u2010Jian","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy, School of Pharmacy Second Military Medical University  Shanghai 200433 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue\u2010Hong","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, School of Pharmacy Second Military Medical University  Shanghai 200433 China"},{"name":"Department of Pharmacy Fujian University of Traditional Chinese Medicine  1 Huatuo Road Fuzhou 350108 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, School of Pharmacy Second Military Medical University  Shanghai 200433 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Ping","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, School of Pharmacy Second Military Medical University  Shanghai 200433 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian\u2010Yong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, School of Pharmacy Second Military Medical University  Shanghai 200433 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu\u2010Ping","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, School of Pharmacy Second Military Medical University  Shanghai 200433 China"},{"name":"Shanghai Key Laboratory for Pharmaceutical Metabolite Research  Shanghai 200433 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,5,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.54.1213"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786410410001704732"},{"key":"e_1_2_6_4_1","first-page":"239","volume-title":"Flora of China","author":"Chinese Academy of Sciences","year":"1979"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.52.136"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.2.753"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.55.1748"},{"key":"e_1_2_6_8_1","first-page":"48","article-title":"Antibacterial experiment on aqueous extract of Veronicastrum cauloptera (Hance) Yamazaka in vitro","volume":"12","author":"Huang KN","year":"2009","journal-title":"J Guangxi Tradit Chin Med Univ"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)00110-2"},{"key":"e_1_2_6_10_1","first-page":"2407","article-title":"Chemical constituents of Huperzia serrate","volume":"42","author":"Luo C","year":"2011","journal-title":"Chin Tradit Herb Drugs"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2009.10.022"},{"key":"e_1_2_6_12_1","first-page":"85","article-title":"Anti\u2010inflammatory effect of 3\u2010acetylaconitine","volume":"5","author":"Tang XC","year":"1984","journal-title":"Acta Pharmacol Sin"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.3736\/jcim20120615"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2009.11.004"},{"key":"e_1_2_6_15_1","first-page":"102","article-title":"Determination of the active constituent in Veronicastrum sibiricun (L.) 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