{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T11:49:28Z","timestamp":1773920968324,"version":"3.50.1"},"reference-count":9,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,6,11]],"date-time":"2014-06-11T00:00:00Z","timestamp":1402444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007359","name":"Fondazione Banco di Sardegna","doi-asserted-by":"crossref","award":["1279"],"award-info":[{"award-number":["1279"]}],"id":[{"id":"10.13039\/100007359","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:p>The triterpene glycyrrhizic acid (GRA), the main product from the <jats:italic>Glycyrrhiza glabra<\/jats:italic> medicinal plant, is known for its antiinflammatory and antimicrobial activity. In this work, GRA was studied for its ability to induce the autophagic process activator Beclin 1 in epithelial cells and to observe how this property could influence its antiviral activity. After 24\u2009h of treatment, GRA induced a Beclin 1 production that was more than twofold higher than that produced by rapamycin, used as a reference compound. When the compounds were added to HeLa cells together with the viruses, GRA demonstrated a strong antiherpes simplex virus type 1 (HSV1) activity, whereas rapamycin had no activity. However, if the compounds were added to the cells 24\u2009h before the viruses, GRA induced the production of an even higher amount of Beclin 1 and showed an improved antiviral effect; under these conditions, rapamycin was also able to exert a significant anti\u2010HSV1 activity. In conclusion, GRA is a strong inducer of the autophagy activator Beclin 1, which establishes a resistance state to HSV1 replication. Copyright \u00a9 2014 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.5189","type":"journal-article","created":{"date-parts":[[2014,6,12]],"date-time":"2014-06-12T00:50:10Z","timestamp":1402534210000},"page":"1890-1892","source":"Crossref","is-referenced-by-count":35,"title":["Autophagy Activation and Antiviral Activity by a Licorice Triterpene"],"prefix":"10.1002","volume":"28","author":[{"given":"Samuela","family":"Laconi","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Section of Microbiology and Virology University of Cagliari  Via Porcell 4 09124 Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria A.","family":"Madeddu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Section of Microbiology and Virology University of Cagliari  Via Porcell 4 09124 Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaello","family":"Pompei","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Section of Microbiology and Virology University of Cagliari  Via Porcell 4 09124 Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,6,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.5184"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/095632020101200206"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01676-09"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2161"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-3542(03)00030-5"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2362"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/281689a0"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/138955709788681636"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-1851"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.5189","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.5189","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T15:23:01Z","timestamp":1696346581000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.5189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,11]]},"references-count":9,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1002\/ptr.5189"],"URL":"https:\/\/doi.org\/10.1002\/ptr.5189","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,11]]}}}