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Open\u2010label, randomized control trial was carried out for 11\u2009days on eight type\u20102 diabetic patients on glyburide therapy. On the first day of the study, following the administration of 5\u2009mg of glyburide, blood samples were collected from the patients at various time intervals ranging from 0.5 to 24\u2009h. Blood sampling was repeated on the 11th day of the study, after treating the patients with curcumin for ten consecutive days. Glyburide concentrations changed at the second hour, Cmax was unchanged, the glucose levels were decreased, Area Under first Movement Curre (AUMC) was increased, and no patient has experienced the hypoglycaemia. The low\u2010density lipoprotein, very\u2010low\u2010density lipoprotein and triglycerides were decreased significantly, and the high\u2010density lipoprotein content increased. The co\u2010administration of curcumin capsules with glyburide may be beneficial to the patients in better glycaemic control. The lipid lowering and antidiabetic properties of the curcumin show as a potential future drug molecule. 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