{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T16:20:23Z","timestamp":1778775623612,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,9,17]],"date-time":"2014-09-17T00:00:00Z","timestamp":1410912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"funder":[{"name":"Oriental Medicine R&D Project, Ministry of Health & Welfare, Republic of Korea","award":["HI11C2114"],"award-info":[{"award-number":["HI11C2114"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p>Jasin\u2010hwan\u2010gagambang (BHH10), a modified prescription of Jasin\u2010hwan, contains<jats:italic>Astragalus membranaceus<\/jats:italic>,<jats:italic>Cinnamomum cassia<\/jats:italic>, and<jats:italic>Phellodendron amurense<\/jats:italic>, and it has been traditionally used to treat osteoporosis and other inflammatory diseases. In this study, we systematically investigated the protective effects of BHH10 in ovariectomy (OVX)\u2010induced rats. Sprague\u2013Dawley rats were randomly divided into sham and OVX subgroups. The rats in the OVX group were treated with vehicle, BHH10, alendronate (ALN), and 17\u03b2\u2010estradiol (E2). BHH10 treatment significantly inhibited OVX\u2010induced increases in body weight and uterus atrophy. In addition, it significantly increased the bone mineral density (BMD) and prevented a decrease in trabecular bone volume, connectivity density, trabecular number, thickness, and separation at the total femur and femur neck. The OVX rats showed significant decreases in the serum levels of calcium and phosphorous and significant increases in the serum levels of cholesterol, low\u2010density lipoprotein cholesterol, alkaline phosphatase, osteocalcin, C\u2010telopeptide type 1 collagen, and bone morphogenetic protein\u20102. These changes were significantly reduced to near sham levels by administration of BHH10 to OVX rats. BHH10\u2010treated rats had a greater bone mass, a better structural architecture of the bone, and higher levels of biochemical markers of the bone than did the ALN\u2010treated or E2\u2010treated rats. These results suggest that BHH10 reverses osteoporosis in OVX rats by stimulating bone formation or regulating bone resorption and is not associated with toxicity. \u00a9 2014 The Authors.<jats:italic>Phytotherapy Research<\/jats:italic>published by John Wiley &amp; Sons Ltd.<\/jats:p>","DOI":"10.1002\/ptr.5218","type":"journal-article","created":{"date-parts":[[2014,9,17]],"date-time":"2014-09-17T07:51:04Z","timestamp":1410940264000},"page":"30-39","source":"Crossref","is-referenced-by-count":17,"title":["The Standardized BHH10 Extract, a Combination of<i>Astragalus membranaceus<\/i>,<i>Cinnamomum cassia<\/i>, and<i>Phellodendron amurense<\/i>, Reverses Bone Mass and Metabolism in a Rat Model of Postmenopausal Osteoporosis"],"prefix":"10.1002","volume":"29","author":[{"given":"Jeong\u2010Eun","family":"Huh","sequence":"first","affiliation":[{"name":"Oriental Medicine Research Center for Bone and Joint Disease, East\u2013West Bone and Joint Research Institute Kyung Hee University 149 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