{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T03:59:18Z","timestamp":1778039958725,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T00:00:00Z","timestamp":1412294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p><jats:italic>Acanthus mollis<\/jats:italic>(Acanthaceae),<jats:italic>Achillea ligustica<\/jats:italic>,<jats:italic>Artemisia arborescens<\/jats:italic>and<jats:italic>Inula viscosa<\/jats:italic>(Asteraceae) are used in Southern Italy against psoriasis and other skin diseases that occur with an imbalanced production of eicosanoids. We here assessed their<jats:italic>in vitro<\/jats:italic>effects upon 5\u2010, 12\u2010, 15\u2010LOX and COX\u20101 enzymes as well as NF\u03baB activation in intact cells as their possible therapeutic targets. All methanol crude extracts inhibited both 5\u2010LOX and COX\u20101 activities under 200\u2009\u00b5g\/mL, without significant effects on the 12\u2010LOX pathway or any relevant<jats:italic>in vitro<\/jats:italic>free radical scavenging activity. NF\u03baB activation was prevented by all extracts but<jats:italic>A. mollis<\/jats:italic>. Interestingly,<jats:italic>A. ligustica<\/jats:italic>,<jats:italic>A. arborescens<\/jats:italic>and<jats:italic>A. mollis<\/jats:italic>increased the biosynthesis of 15(<jats:italic>S<\/jats:italic>)\u2010HETE, an anti\u2010inflammatory eicosanoid.<jats:italic>A. ligustica<\/jats:italic>(IC<jats:sub>50<\/jats:sub>\u2009=\u200949.5\u2009\u00b5g\/mL) was superior to<jats:italic>Silybum marianum<\/jats:italic>(IC<jats:sub>50<\/jats:sub>\u2009=\u2009147.8\u2009\u00b5g\/mL), which we used as antipsoriatic herbal medicine of reference. Its<jats:italic>n<\/jats:italic>\u2010hexane, dichloromethane and ethyl acetate fractions had also inhibitory effects on the LTB<jats:sub>4<\/jats:sub>biosynthesis (IC<jats:sub>50<\/jats:sub>s\u2009=\u20099.6, 20.3 and 68\u2009\u00b5g\/mL, respectively) evidencing that the apolar extracts of<jats:italic>A. ligustica<\/jats:italic>are promising active herbal ingredients for future phytotherapeutical products targeting psoriasis. \u00a9 2014 The Authors.<jats:italic>Phytotherapy Research<\/jats:italic>published by John Wiley &amp; Sons Ltd.<\/jats:p>","DOI":"10.1002\/ptr.5234","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T05:34:06Z","timestamp":1412314446000},"page":"108-113","source":"Crossref","is-referenced-by-count":30,"title":["Modulation of Cox\u20101, 5\u2010, 12\u2010 and 15\u2010Lox by Popular Herbal Remedies Used in Southern Italy Against Psoriasis and Other Skin Diseases"],"prefix":"10.1002","volume":"29","author":[{"given":"Ammar","family":"Bader","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Umm Al\u2010Qura University Makkah 21955 Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Martini","sequence":"additional","affiliation":[{"name":"Departament de Farmacologia, Facultat de Farmacia Universitat de Valencia 46100 Burjassot Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo R.","family":"Schinella","sequence":"additional","affiliation":[{"name":"Departament de Farmacologia, Facultat de Farmacia Universitat de Valencia 46100 Burjassot Valencia Spain"},{"name":"Catedra de Farmacologia Basica, Facultad de Ciencias Medicas Universidad Nacional de La Plata, CIC Provincia de Buenos Aires 1900 La Plata Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose 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