{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T08:25:24Z","timestamp":1768811124024,"version":"3.49.0"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,9,30]],"date-time":"2014-09-30T00:00:00Z","timestamp":1412035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000782","name":"European Science Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000782","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ministry for Education and Youth of the Czech Republic","award":["CZ.1.07\/2.3.00\/30.0040"],"award-info":[{"award-number":["CZ.1.07\/2.3.00\/30.0040"]}]},{"DOI":"10.13039\/501100006206","name":"Czech University of Life Sciences Prague","doi-asserted-by":"crossref","award":["CIGA 20125009"],"award-info":[{"award-number":["CIGA 20125009"]}],"id":[{"id":"10.13039\/501100006206","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006206","name":"Czech University of Life Sciences Prague","doi-asserted-by":"crossref","award":["IGA 20145021"],"award-info":[{"award-number":["IGA 20145021"]}],"id":[{"id":"10.13039\/501100006206","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p>Plumbagin (5\u2010hydroxy\u20102\u2010methyl\u20101,4\u2010naphthoquinone), a bicyclic naphthoquinone naturally distributed among <jats:italic>Plumbago<\/jats:italic> species, has been reported to have antimicrobial activity against a wide range of microorganisms. In this study, plumbagin was examined for its combinatory antimicrobial effect with tetracycline or oxacillin against nine strains of <jats:italic>Staphylococcus aureus<\/jats:italic>, including its methicillin\u2010 and multidrug\u2010resistant strains. Minimum inhibitory concentrations were determined through the broth microdilution method, whereas the combinatory effect was evaluated according to the sum of fractional inhibitory concentration (\u03a3FIC) indices. Additive interactions were obtained for both combinations against most of the strains tested. Synergy was obtained for combination with oxacillin against two out of seven strains (\u03a3FIC range 0.273\u20130.281), both were methicillin resistant. Our results proved plumbagin as a compound suitable for anti\u2010Staphylococcal combinatory testing. Moreover, to the best of our knowledge, this is the first report of plumbagin synergy with oxacillin against <jats:italic>S. aureus<\/jats:italic> strains, including its resistant forms. Copyright \u00a9 2014 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.5237","type":"journal-article","created":{"date-parts":[[2014,9,30]],"date-time":"2014-09-30T11:00:43Z","timestamp":1412074843000},"page":"144-147","source":"Crossref","is-referenced-by-count":25,"title":["<i>In vitro<\/i> Combinatory Antimicrobial Effect of Plumbagin with Oxacillin and Tetracycline against <i>Staphylococcus aureus<\/i>"],"prefix":"10.1002","volume":"29","author":[{"given":"Johana","family":"Rondevaldova","sequence":"first","affiliation":[{"name":"Department of Crop Sciences and Agroforestry, Faculty of Tropical AgriSciences Czech University of Life Sciences Prague  Kamycka 129, 165 21 Prague 6\u2010Suchdol Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavel","family":"Novy","sequence":"additional","affiliation":[{"name":"Department of Crop Production, Faculty of Agrobiology, Food and Natural Resources Czech University of Life Sciences Prague  Kamycka 129, 165 21 Prague 6\u2010Suchdol Czech Republic"},{"name":"Department of Quality of Agricultural Products, Faculty of Agrobiology, Food and Natural Resources Czech University of Life Sciences Prague  Kamycka 129, 165 21 Prague 6\u2010Suchdol Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ladislav","family":"Kokoska","sequence":"additional","affiliation":[{"name":"Department of Crop Sciences and Agroforestry, Faculty of Tropical AgriSciences Czech University of Life Sciences Prague  Kamycka 129, 165 21 Prague 6\u2010Suchdol Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,9,30]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1147","article-title":"Review: Use of bioactive plant products in combination with standard antibiotics: implications in antimicrobial chemotherapy","volume":"3","author":"Aiyegoro OA","year":"2009","journal-title":"J Med Plants Res"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(10)70227-9"},{"key":"e_1_2_6_4_1","volume-title":"Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically: Approved Standard","author":"Clinical and Laboratory Standards Institute","year":"2009"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.12.4.564"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762003000700017"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2013.51"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2013.03.056"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6976.2006.00024.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1420"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr108"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2012.12.010"},{"key":"e_1_2_6_13_1","first-page":"171","article-title":"Reduced toxicity and enhanced antitumor efficacy of betacyclodextrin plumbagin inclusion complex in mice bearing ehrich ascites carcinoma","volume":"41","author":"Singh UV","year":"1997","journal-title":"Indian J Physiol Pharmacol"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.5.4.387"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1250736"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.5237","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.5237","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T01:01:52Z","timestamp":1696467712000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.5237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,30]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1002\/ptr.5237"],"URL":"https:\/\/doi.org\/10.1002\/ptr.5237","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,30]]}}}