{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T14:23:55Z","timestamp":1791987835614,"version":"4.4.0"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":259,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytother. Res."],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1002\/ptr.5275","type":"journal-article","created":{"date-parts":[[2014,12,16]],"date-time":"2014-12-16T06:32:05Z","timestamp":1418711525000},"page":"459-465","source":"Crossref","is-referenced-by-count":34,"title":["Xanthine Oxidase Inhibitory Activity of Extracts Prepared from Polygonaceae Species"],"prefix":"10.1002","volume":"29","author":[{"given":"Orsolya","family":"Orb\u00e1n-Gyapai","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy; University of Szeged; E\u00f6tv\u00f6s u. 6 H-6720 Szeged Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ildik\u00f3","family":"Lajter","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy; University of Szeged; E\u00f6tv\u00f6s u. 6 H-6720 Szeged Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judit","family":"Hohmann","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy; University of Szeged; E\u00f6tv\u00f6s u. 6 H-6720 Szeged Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guszt\u00e1v","family":"Jakab","sequence":"additional","affiliation":[{"name":"Institute of Environmental Sciences, Faculty of Water and Environmental Management; Szent Istv\u00e1n University; Szabads\u00e1g u. 1-3 H-5540 Szarvas Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Vasas","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy; University of Szeged; E\u00f6tv\u00f6s u. 6 H-6720 Szeged Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,16]]},"reference":[{"key":"10.1002\/ptr.5275-BIB0001|ptr5275-cit-0001","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jep.2010.08.017","article-title":"An ethnobotanical survey of medicinal plants in Sivrice (Elaz\u0131\u011f-Turkey)","volume":"132","author":"Cakilcioglu","year":"2010","journal-title":"J Ethnopharmacol"},{"key":"10.1002\/ptr.5275-BIB0002|ptr5275-cit-0002","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1021\/np970237h","article-title":"Structure-activity relationship and classification of flavonoids as inhibitors of xanthine oxidase and superoxide scavengers","volume":"61","author":"Cos","year":"1998","journal-title":"J Nat Prod"},{"key":"10.1002\/ptr.5275-BIB0003|ptr5275-cit-0003","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1002\/ptr.2755","article-title":"Antiproliferative activity of Hungarian Asteraceae species against human cancer cell lines. Part II","volume":"23","author":"Csupor-L\u00f6ffler","year":"2009","journal-title":"Phytother Res"},{"key":"10.1002\/ptr.5275-BIB0004|ptr5275-cit-0004","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0031-9422(00)00368-X","article-title":"Five naphthalene glycosides from the roots of Rumex patientia","volume":"56","author":"Demirezer","year":"2001","journal-title":"Phytochemistry"},{"key":"10.1002\/ptr.5275-BIB0005|ptr5275-cit-0005","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1016\/0031-9422(80)85063-1","article-title":"A potent cytotoxic warburganal and related drimane-type sesquiterpenoids from Polygonum hydropiper","volume":"21","author":"Fukuyama","year":"1982","journal-title":"Phytochemistry"},{"key":"10.1002\/ptr.5275-BIB0006|ptr5275-cit-0006","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1055\/s-0030-1249779","article-title":"Anti-inflammatory, cyclooxygenase (COX)-2, COX-1 inhibitory, and free radical scavenging effects of Rumex nepalensis","volume":"76","author":"Gautam","year":"2010","journal-title":"Planta Med"},{"key":"10.1002\/ptr.5275-BIB0007|ptr5275-cit-0007","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/S0891-5849(02)00956-5","article-title":"Structure and function of xanthine oxidoreductase: where are we now?","volume":"33","author":"Harrison","year":"2002","journal-title":"Free Radic Biol Med"},{"key":"10.1002\/ptr.5275-BIB0008|ptr5275-cit-0008","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1080\/10942912.2011.575497","article-title":"Antioxidant and Xanthine Oxidase inhibitory activities of Persicaria hydropiper","volume":"16","author":"Hashim","year":"2013","journal-title":"Int J Food Prop"},{"key":"10.1002\/ptr.5275-BIB0009|ptr5275-cit-0009","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1007\/978-3-0348-9256-8_54","volume-title":"Chemotaxonomie der Pfanzen Volume 9","author":"Hegnauer","year":"1990"},{"key":"10.1002\/ptr.5275-BIB0010|ptr5275-cit-0010","doi-asserted-by":"crossref","first-page":"663","DOI":"10.2478\/s11696-010-0054-2","article-title":"Chemical evaluation of Fallopia species leaves and antioxidant properties of their non-cellulosic polysaccharides","volume":"64","author":"Hrom\u00e1dkov\u00e1","year":"2010","journal-title":"Chem Paper"},{"key":"10.1002\/ptr.5275-BIB0011|ptr5275-cit-0011","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.biomed.2012.03.003","article-title":"Anticancer potential of emodin","volume":"2","author":"Hsu","year":"2012","journal-title":"BioMed"},{"key":"10.1002\/ptr.5275-BIB0012|ptr5275-cit-0012","volume-title":"Iconographia florae partis Austro-Orientalis Europae centralis","author":"J\u00e1vorka","year":"1991"},{"key":"10.1002\/ptr.5275-BIB0013|ptr5275-cit-0013","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1042\/CBI20100723","article-title":"Apoptosis by aloe-emodin is mediated through down-regulation of calpain-2 and ubiquitin-protein ligase E3A in human hepatoma Huh-7 cells","volume":"36","author":"Jeon","year":"2012","journal-title":"Cell Biol Int"},{"key":"10.1002\/ptr.5275-BIB0014|ptr5275-cit-0014","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0378-8741(00)00305-6","article-title":"Inhibition of xanthine oxidase by some Chinese medicinal plants used to treat gout","volume":"73","author":"Kong","year":"2000","journal-title":"J Ethnopharmacol"},{"key":"10.1002\/ptr.5275-BIB0015|ptr5275-cit-0015","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/ptr.4690","article-title":"Antiproliferative activity of Polygonaceae species from the Carpathian Basin against human cancer cell lines","volume":"27","author":"Lajter","year":"2013","journal-title":"Phytother Res"},{"key":"10.1002\/ptr.5275-BIB0016|ptr5275-cit-0016","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.canlet.2008.05.040","article-title":"Mitochondria-cytochrome C-caspase-9 cascade mediates isorhamnetin-induced apoptosis","volume":"270","author":"Lee","year":"2008","journal-title":"Cancer Lett"},{"key":"10.1002\/ptr.5275-BIB0017|ptr5275-cit-0017","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.cbi.2008.07.003","article-title":"Lithospermic acid as a novel xanthine oxidase inhibitor has anti-inflammatory and hypouricemic effects in rats","volume":"176","author":"Liu","year":"2008","journal-title":"Chem Biol Interact"},{"key":"10.1002\/ptr.5275-BIB0018|ptr5275-cit-0018","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.brainres.2010.05.079","article-title":"Neuroprotective effects of emodin in rat cortical neurons against \u03b2-amyloid-induced neurotoxicity","volume":"1347","author":"Liu","year":"2010","journal-title":"Brain Res"},{"key":"10.1002\/ptr.5275-BIB0019|ptr5275-cit-0019","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/ptr.3234","article-title":"Antioxidant activity of yellow dock (Rumex crispus L., Polygonaceae) fruit extract","volume":"25","author":"Maksimovic","year":"2011","journal-title":"Phytother Res"},{"key":"10.1002\/ptr.5275-BIB0020|ptr5275-cit-0020","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1590\/S0102-695X2009000500017","article-title":"Antinociceptive, anti-inflammatory and diuretic properties of Polygonum barbatum (L.) Hara var. barbatum","volume":"19","author":"Mazid","year":"2009","journal-title":"Braz J Pharmacogn"},{"key":"10.1002\/ptr.5275-BIB0021|ptr5275-cit-0021","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s11418-013-0810-z","article-title":"Antidyslipidemic effect and antioxidant activity of anthraquinone derivatives from Rheum emodi rhizomes in dyslipidemic rats","volume":"68","author":"Mishra","year":"2014","journal-title":"J Nat Med"},{"key":"10.1002\/ptr.5275-BIB0022|ptr5275-cit-0022","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0378-8741(98)00119-6","article-title":"Xanthine oxidase inhibitory activity of northeastern North America plant remedies used for gout","volume":"64","author":"Owen","year":"1999","journal-title":"J Ethnopharmacol"},{"key":"10.1002\/ptr.5275-BIB0023|ptr5275-cit-0023","doi-asserted-by":"crossref","first-page":"86","DOI":"10.3989\/gya.075509","article-title":"Antioxidant activity of wild edible plants in the Black Sea Region of Turkey","volume":"61","author":"\u00d6zen","year":"2010","journal-title":"Grasas y Aceites"},{"key":"10.1002\/ptr.5275-BIB0024|ptr5275-cit-0024","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1124\/pr.58.1.6","article-title":"Therapeutic effects of xanthine oxidase inhibitors: Renaissance half a century after the discovery of allopurinol","volume":"58","author":"Pacher","year":"2006","journal-title":"Pharmacol Rev"},{"key":"10.1002\/ptr.5275-BIB0025|ptr5275-cit-0025","first-page":"428","article-title":"Role of oxygen free radicals in shock, ischemia, and organ preservation","volume":"94","author":"Parks","year":"1983","journal-title":"Surgery"},{"key":"10.1002\/ptr.5275-BIB0026|ptr5275-cit-0026","first-page":"76","article-title":"A study on the nutraceuticals from the genus Rumex","volume":"3","author":"Rao","year":"2011","journal-title":"Hygeia JD Med"},{"key":"10.1002\/ptr.5275-BIB0027|ptr5275-cit-0027","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1002\/ptr.2240","article-title":"Antiproliferative activity of Hungarian Asteraceae species against human cancer cell lines. Part I","volume":"21","author":"R\u00e9thy","year":"2007","journal-title":"Phytother Res"},{"key":"10.1002\/ptr.5275-BIB0028|ptr5275-cit-0028","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.foodchem.2007.12.064","article-title":"Antibacterial properties of Polygonum cuspidatum roots and their major bioactive constituents","volume":"109","author":"Shan","year":"2008","journal-title":"Food Chem"},{"key":"10.1002\/ptr.5275-BIB0029|ptr5275-cit-0029","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1002\/ptr.5115","article-title":"Xanthine oxidase inhibitory activity of Hungarian wild-growing mushrooms","volume":"28","author":"V\u00e1nyol\u00f3s","year":"2014","journal-title":"Phytother Res"},{"key":"10.1002\/ptr.5275-BIB0030|ptr5275-cit-0030","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.fitote.2009.08.020","article-title":"Anti-diabetic effects of emodin involved in the activation of PPAR\u03b3 on high-fat diet-fed and low dose of streptozotocin-induced diabetic mice","volume":"81","author":"Xue","year":"2010","journal-title":"Fitoterapia"},{"key":"10.1002\/ptr.5275-BIB0031|ptr5275-cit-0031","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/S0031-9422(00)90632-0","article-title":"Antioxidative sulphated flavonoids in leaves of Polygonum hydropiper","volume":"35","author":"Yagi","year":"1994","journal-title":"Phytochemistry"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.5275","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/ptr.5275","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,4]],"date-time":"2021-07-04T02:26:24Z","timestamp":1625365584000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.5275"}},"subtitle":["XANTHINE OXIDASE INHIBITORY ACTIVITY OF POLYGONACEAE SPECIES"],"short-title":[],"issued":{"date-parts":[[2014,12,16]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"URL":"https:\/\/doi.org\/10.1002\/ptr.5275","relation":{},"ISSN":["0951-418X"],"issn-type":[{"value":"0951-418X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12,16]]}}}