{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T18:08:04Z","timestamp":1782151684321,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,3,16]],"date-time":"2015-03-16T00:00:00Z","timestamp":1426464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003093","name":"Ministry of Education, Malaysia","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:p><jats:italic>Glycyrrhiza glabra<\/jats:italic> L. (Fabaceae), commonly known as \u2018liquorice\u2019, is a well\u2010known medicinal plant. Roots of this plant have long been used as a sweetening and flavouring agent in food and pharmaceutical products, and also as a traditional remedy for cough, upper and lower respiratory ailments, kidney stones, hepatitis C, skin disorder, cardiovascular diseases, diabetes, gastrointestinal ulcers and stomach ache. Previous pharmacological and clinical studies have revealed its antitussive, antiinflammatory, antiviral, antimicrobial, antioxidant, immunomodulatory, hepatoprotective and cardioprotective properties. While glycyrrhizin, a sweet\u2010tasting triterpene saponin, is the principal bioactive compound, several bioactive flavonoids and isoflavonoids are also present in the roots of this plant. In the present study, the cytotoxicity of the methanol extracts of nine samples of the roots of <jats:italic>G<\/jats:italic>.\u2009<jats:italic>glabra<\/jats:italic>, collected from various geographical origins, was assessed against immortal human keratinocyte (HaCaT), lung adenocarcinoma (A549) and liver carcinoma (HepG2) cell lines using the <jats:italic>in vitro<\/jats:italic> 3\u2010[4,5\u2010dimethylthiazol\u20102\u2010yl]\u20102,5\u2010diphenyl tetrazoliumbromide cell toxicity\/viability assay. Considerable variations in levels of cytotoxicity were observed among various samples of <jats:italic>G<\/jats:italic>.\u2009<jats:italic>glabra<\/jats:italic>. Copyright \u00a9 2015 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.5329","type":"journal-article","created":{"date-parts":[[2015,3,16]],"date-time":"2015-03-16T10:01:42Z","timestamp":1426500102000},"page":"944-948","source":"Crossref","is-referenced-by-count":36,"title":["Comparative Cytotoxicity of <scp><i>Glycyrrhiza glabra<\/i><\/scp> Roots from Different Geographical Origins Against Immortal Human Keratinocyte (HaCaT), Lung Adenocarcinoma (A549) and Liver Carcinoma (HepG2) Cells"],"prefix":"10.1002","volume":"29","author":[{"given":"Norazah","family":"Basar","sequence":"first","affiliation":[{"name":"Medicinal Chemistry and Natural Products Research Group, School of Pharmacy and Biomolecular Sciences, Faculty of Science Liverpool John Moores University  James Parsons Building, Byrom Street Liverpool L3 3AF England UK"},{"name":"Department of Chemistry, Faculty of Science Universiti Teknologi Malaysia  81310 Johor Bahru Johor 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