{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:22:58Z","timestamp":1791429778786,"version":"4.3.3"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,4,8]],"date-time":"2015-04-08T00:00:00Z","timestamp":1428451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"CSIR, New Delhi"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:p><jats:italic>Azadirachta indica<\/jats:italic>is well known medicinal plant mentioned in ancient herbal texts. It has been extensively used in Ayurvedic, Unani and Homoeopathic medicine and has become a luminary of modern medicine. As part of our drug discovery program we isolated azadiradione from the ethanolic extract of seeds of<jats:italic>A. indica<\/jats:italic>and evaluated for<jats:italic>in\u2010vivo<\/jats:italic>antiulcer activity in cold restraint induced gastric ulcer model, aspirin induced gastric ulcer model, alcohol induced gastric ulcers model and pyloric ligation induced ulcer model. Azadiradione exhibited potent antiulcer activity through the inhibition of H+ K+\u2010ATPase (proton pump) activity via its cytoprotective effect and also via its antisecretory effect. This combined effect has valuable potential in the future treatment of peptic ulceration. Copyright \u00a9 2015 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.5332","type":"journal-article","created":{"date-parts":[[2015,4,8]],"date-time":"2015-04-08T06:16:38Z","timestamp":1428473798000},"page":"910-916","source":"Crossref","is-referenced-by-count":20,"title":["Cytoprotective and Anti\u2010secretory Effects of Azadiradione Isolated from the Seeds of<i>Azadirachta indica<\/i>(neem) on Gastric Ulcers in Rat Models"],"prefix":"10.1002","volume":"29","author":[{"given":"Rohit","family":"Singh","sequence":"first","affiliation":[{"name":"Medicinal and Process Chemistry Division CSIR\u2010Central Drug Research Institute Lucknow 226031 Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaibhav","family":"Mishra","sequence":"additional","affiliation":[{"name":"Division of Pharmacology CSIR\u2010Central Drug Research Institute Lucknow 226031 Uttar Pradesh India"},{"name":"Department of Biochemistry Banaras Hindu University Varanasi 221005 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