{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T17:55:41Z","timestamp":1784224541792,"version":"3.55.0"},"reference-count":44,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,4,7]],"date-time":"2015-04-07T00:00:00Z","timestamp":1428364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:p>This paper was designed to investigate anticonvulsant and sedative effects of eudesmin isolated from <jats:italic>Acorus tatarinowii<\/jats:italic>. The eudesmin (5, 10, and 20\u2009mg\/kg) was administered intraperitoneally (i.p.). The maximal electroshock test (MES) and pentylenetertrazole (PTZ)\u2010induced seizures in male mice were used to evaluate anticonvulsant activities of eudesmin, and sedative effects of eudesmin were evaluated by pentobarbital sodium\u2010induced sleeping time (PST) and locomotor activity in mice. Finally, the mechanisms of eudesmin were investigated by determining contents of glutamic acid (Glu) and gamma\u2010aminobutyric acid (GABA) in epileptic mice, and expressions of glutamate decarboxylase 65 (GAD65), GABA<jats:sub>A<\/jats:sub>, Bcl\u20102, and caspase\u20103 in the brain of chronic epileptic rats. Results of MES and PTZ tests revealed that eudesmin possesses significant anticonvulsant effects, and the PST and locomotor activity tests demonstrated that eudesmin has significant sedative effects. Furthermore, our study revealed that after treatment with eudesmin, GABA contents increased, whereas Glu contents decreased, and ratio of Glu\/GABA decreased. Our results also indicated that expressions of GAD65, GABAA, and Bcl\u20102 were up\u2010regulated by treating with eudesmin, whereas the caspase\u20103 obviously was down\u2010regulated. In conclusion, eudesmin has significant anticonvulsant and sedative effects, and the mechanism of eudesmin may be related to up\u2010regulation of GABA<jats:sub>A<\/jats:sub> and GAD65 expressions, and anti\u2010apoptosis of neuron the in brain. Copyright \u00a9 2015 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.5337","type":"journal-article","created":{"date-parts":[[2015,4,7]],"date-time":"2015-04-07T11:18:58Z","timestamp":1428405538000},"page":"996-1003","source":"Crossref","is-referenced-by-count":38,"title":["Anticonvulsant and Sedative Effects of Eudesmin isolated from <i>Acorus tatarinowii<\/i> on mice and rats"],"prefix":"10.1002","volume":"29","author":[{"given":"Hao","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Neurosurgery The Third Xiangya Hospital of Central South University  Changsha Hunan 410013 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Neurology The Third Xiangya Hospital of Central South University  Changsha Hunan 410013 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