{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T17:25:40Z","timestamp":1767979540841,"version":"3.49.0"},"reference-count":10,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,4,8]],"date-time":"2015-04-08T00:00:00Z","timestamp":1428451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"name":"MCTI\/SETI\/Funda\u00e7\u00e3o Arauc\u00e1ria"},{"name":"Parana State Government"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:p><jats:italic>Hypericum perforatum<\/jats:italic> is a medicinal plant with anti\u2010inflammatory and antioxidant properties, which is commercially available for therapeutic use in Brazil. Herein the effect of <jats:italic>H. perforatum<\/jats:italic> extract on paracetamol (acetaminophen)\u2010induced hepatotoxicity, lethality, inflammation, and oxidative stress in male swiss mice were investigated. HPLC analysis demonstrated the presence of rutin, quercetin, hypericin, pseudohypericin, and hyperforin in <jats:italic>H. perforatum<\/jats:italic> extract. Paracetamol (0.15\u20133.0\u2009g\/kg, p.o.) induced dose\u2010dependent mortality. The sub\u2010maximal lethal dose of paracetamol (1.5\u2009g\/kg, p.o.) was chosen for the experiments in the study. <jats:italic>H. perforatum<\/jats:italic> (30\u2013300\u2009mg\/kg, i.p.) dose\u2010dependently reduced paracetamol\u2010induced lethality. Paracetamol\u2010induced increase in plasma aspartate aminotransferase (AST) and alanine aminotransferase (ALT) concentrations, and hepatic myeloperoxidase activity, IL\u20101\u03b2, TNF\u2010\u03b1, and IFN\u2010\u03b3 concentrations as well as decreased reduced glutathione (GSH) concentrations and capacity to reduce 2,2\u2032\u2010azinobis\u2010(3\u2010ethylbenzothiazoline\u20106\u2010sulfonate radical cation; ABTS\u02d9<jats:sup>+<\/jats:sup>) were inhibited by <jats:italic>H. perforatum<\/jats:italic> (300\u2009mg\/kg, i.p.) treatment. Therefore, <jats:italic>H. perforatum<\/jats:italic> protects mice against paracetamol\u2010induced lethality and liver damage. This effect seems to be related to the reduction of paracetamol\u2010induced cytokine production, neutrophil recruitment, and oxidative stress. Copyright \u00a9 2015 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.5350","type":"journal-article","created":{"date-parts":[[2015,4,8]],"date-time":"2015-04-08T09:41:09Z","timestamp":1428486069000},"page":"1097-1101","source":"Crossref","is-referenced-by-count":39,"title":["<i>Hypericum perforatum<\/i> Reduces Paracetamol\u2010Induced Hepatotoxicity and Lethality in Mice by Modulating Inflammation and Oxidative Stress"],"prefix":"10.1002","volume":"29","author":[{"given":"Miriam S. N.","family":"Hohmann","sequence":"first","affiliation":[{"name":"Department of Pathology, Biological Science Centre State University of Londrina  Londrina PR Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato D. R.","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Department of Pathology, Biological Science Centre State University of Londrina  Londrina PR Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Fattori","sequence":"additional","affiliation":[{"name":"Department of Pathology, Biological Science Centre State University of Londrina  Londrina PR Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nilton S.","family":"Arakawa","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Health Sciences Centre State University of Londrina  Londrina PR Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 C.","family":"Tomaz","sequence":"additional","affiliation":[{"name":"N\u00facleo de Pesquisa em Produtos Naturais e Sint\u00e9ticos, Departamento de Qu\u00edmica e F\u00edsica, Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto Universidade de S\u00e3o Paulo  Av. do caf\u00e9, s\/n, Campus universit\u00e1rio, Monte Alegre 14040\u2010903 Ribeir\u00e3o Preto SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norberto P.","family":"Lopes","sequence":"additional","affiliation":[{"name":"N\u00facleo de Pesquisa em Produtos Naturais e Sint\u00e9ticos, Departamento de Qu\u00edmica e F\u00edsica, Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto Universidade de S\u00e3o Paulo  Av. do caf\u00e9, s\/n, Campus universit\u00e1rio, Monte Alegre 14040\u2010903 Ribeir\u00e3o Preto SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rubia","family":"Casagrande","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Health Sciences Centre State University of Londrina  Londrina PR Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Waldiceu A.","family":"Verri","sequence":"additional","affiliation":[{"name":"Department of Pathology, Biological Science Centre State University of Londrina  Londrina PR Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10616-013-9595-x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/66.1.27"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.shk.0000175428.57769.34"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-009-0078-3"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/627046"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0046com"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20312"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21175"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-10-73"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/109662002763003366"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.5350","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.5350","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.5350","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T02:26:01Z","timestamp":1696472761000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.5350"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,8]]},"references-count":10,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1002\/ptr.5350"],"URL":"https:\/\/doi.org\/10.1002\/ptr.5350","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,8]]}}}