{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T07:46:50Z","timestamp":1791013610624,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,5,5]],"date-time":"2015-05-05T00:00:00Z","timestamp":1430784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Colciencias-COLOMBIA","award":["111548925424"],"award-info":[{"award-number":["111548925424"]}]},{"name":"CIDEPRO"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:p>Based on the previously reported <jats:italic>in vitro<\/jats:italic> antiplasmodial activity of several xanthones from <jats:italic>Garcinia mangostana<\/jats:italic>, two xanthones, \u03b1\u2010mangostin and a new compound, \u03b4\u2010mangostin, were isolated from mangosteen husk, and the <jats:italic>in vitro<\/jats:italic> antiplasmodial and cytotoxic effects were determined. \u03b1\u2010Mangostin was more active against the resistant <jats:italic>Plasmodium falciparum chloroquine\u2010resistant<\/jats:italic> (FCR3) strain (IC<jats:sub>50<\/jats:sub>\u2009=\u20090.2\u2009\u00b1\u20090.01\u2009\u03bcM) than \u03b4\u2010mangostin (IC<jats:sub>50<\/jats:sub>\u2009=\u2009121.2\u2009\u00b1\u20091.0\u2009\u03bcM). Furthermore, the therapeutic response according to the administration route was evaluated in a <jats:italic>Plasmodium berghei<\/jats:italic> malarial murine model. The greatest therapeutic response was obtained with intraperitoneal administration; these xanthones reduced parasitemia by approximately 80% with a daily dose of 100\u2009mg\/kg administered twice a day for 7\u2009days of treatment. Neither compound was effective by oral administration. Noticeable toxicological effects were not observed. In addition to the antimalarial effect of these xanthones isolated from <jats:italic>G.\u2009mangostana<\/jats:italic> husk, the availability of larger amounts of husk raw material to purify the bioactive xanthones is advantageous, permitting additional preclinical assays or chemical transformations to enhance the biological activity of these substances. Copyright \u00a9 2015 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.5362","type":"journal-article","created":{"date-parts":[[2015,5,5]],"date-time":"2015-05-05T14:16:03Z","timestamp":1430835363000},"page":"1195-1201","source":"Crossref","is-referenced-by-count":48,"title":["<i>In vivo<\/i> Antimalarial Activity of \u03b1\u2010Mangostin and the New Xanthone \u03b4\u2010Mangostin"],"prefix":"10.1002","volume":"29","author":[{"given":"Yulieth","family":"Upegui","sequence":"first","affiliation":[{"name":"PECET, Medical Research Institute, School of Medicine University of Antioquia  Calle 67 No. 53\u2010108 Medell\u00edn 050010 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara M.","family":"Robledo","sequence":"additional","affiliation":[{"name":"PECET, Medical Research Institute, School of Medicine University of Antioquia  Calle 67 No. 53\u2010108 Medell\u00edn 050010 Colombia"},{"name":"Center for Development of Products against Tropical Diseases 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