{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T01:56:11Z","timestamp":1775008571698,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,8,3]],"date-time":"2015-08-03T00:00:00Z","timestamp":1438560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Deanship of Scientific Research (DSR), King Abdulaziz University, Jeddah","award":["188\/166\/1433"],"award-info":[{"award-number":["188\/166\/1433"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:p>Diabetes mellitus is possibly the world's largest growing metabolic disorder. Effective treatment of diabetes is increasingly dependent on active constituents of medicinal plants capable of controlling hyperglycemia as well as its secondary complications. <jats:italic>Viscum schimperi<\/jats:italic> Engl. is a plant growing in Saudi Arabia and known for its antidiabetic activity. The potential antidiabetic activity of its methanol extract as well as its chloroform, <jats:italic>n<\/jats:italic>\u2010butanol, and the remaining water fractions was evaluated in streptozotocin\u2010induced diabetic rats at two dose levels. The antidiabetic activity was assessed through the determination of fasting blood glucose level, insulin levels, area under the curve (AUC) in oral glucose tolerance test, glucose absorption in isolated rat gut assay, and glucose uptake by psoas muscle. Moreover, large\u2010scale untargeted metabolite profiling of methanol extract was performed via UPLC\u2010PDA and qTOF\u2010MS (ultra\u2010performance liquid chromatography photodiode array detection and quadrupole time\u2010of\u2010flight mass spectrometry) respectively, to explore its chemical composition and standardization of its extract. Multivariate statistical analysis including principal component analysis and orthogonal projection to latent structures discriminant analysis was used to determine bioactives in its fractions. In conclusion, oleanane triterpenes and <jats:italic>O<\/jats:italic>\u2010caffeoyl quinic acid conjugates were the major compounds that might account for antihyperglycemic effect of the plant. Copyright \u00a9 2015 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.5424","type":"journal-article","created":{"date-parts":[[2015,8,3]],"date-time":"2015-08-03T06:17:34Z","timestamp":1438582654000},"page":"1737-1743","source":"Crossref","is-referenced-by-count":10,"title":["Mechanistic Evidence of <scp><i>Viscum schimperi<\/i><\/scp> (Viscaceae) Antihyperglycemic Activity: From a Bioactivity\u2010guided Approach to Comprehensive Metabolite Profiling"],"prefix":"10.1002","volume":"29","author":[{"given":"Hossam M.","family":"Abdallah","sequence":"first","affiliation":[{"name":"Department of Natural Products, Faculty of Pharmacy King Abdulaziz University  Jeddah 21589 Saudi Arabia"},{"name":"Department of Pharmacognosy, Faculty of Pharmacy Cairo University  Cairo 11562 Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed A.","family":"Farag","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Cairo 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