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Many studies have explored its biomedical properties, such as anticancer, antibacterial, antimutagenic, antioxidant, antidiabetic, antiinflammatory and antihypertensive activities. However, the effects of TA on the L\u2010type Ca<jats:sup>2+<\/jats:sup> current (<jats:italic>I<\/jats:italic><jats:sub>Ca\u2010L<\/jats:sub>) of cardiomyocytes remain undefined. The present study examined the effects of TA on <jats:italic>I<\/jats:italic><jats:sub>Ca\u2010L<\/jats:sub> using the whole\u2010cell patch\u2010clamp technique and on intracellular Ca<jats:sup>2+<\/jats:sup> handling and cell contractility in rat ventricular myocytes with the aid of a video\u2010based edge detection system. Exposure to TA resulted in a concentration\u2010 and voltage\u2010dependent blockade of <jats:italic>I<\/jats:italic><jats:sub>Ca\u2010L<\/jats:sub>, with the half maximal inhibitory concentration of 1.69\u2009\u03bcM and the maximal inhibitory effect of 46.15%. Moreover, TA significantly inhibited the amplitude of myocyte shortening and peak value of Ca<jats:sup>2+<\/jats:sup> transient and increased the time to 10% of the peak. These findings provide new experimental evidence for the cellular mechanism of action of TA and may help to expand clinical treatments for cardiovascular disease. 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