{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T04:57:02Z","timestamp":1783573022010,"version":"3.55.0"},"reference-count":84,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,8,19]],"date-time":"2016-08-19T00:00:00Z","timestamp":1471564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"by Chigurupati Technologies Private Limited"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:p>Traditionally, licorice has been used to treat liver problems. Glycyrrhizin, the primary active compound, has been shown to suppress elevations in liver enzymes that occur when the liver becomes diseased or damaged. This randomized, double\u2010blind, placebo\u2010controlled, crossover study evaluated the hepatoprotective effects of a proprietary glycyrrhizin product during alcohol consumption. Twelve healthy individuals (six male and six female subjects) in a clinic setting consumed vodka nightly for 12\u2009days with the glycyrrhizin product or placebo (blank control), achieving a blood alcohol level of 0.12%. Liver function enzymes including alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma\u2010glutamyl transferase (GGT), and alkaline phosphatase and serum reduced glutathione were measured at overnight visits 1, 6, and 12. In the alcohol only group, AST, ALT, and GGT significantly increased from baseline (overnight visit 1) to overnight visit 12. In the active group, no statistically significant increases were observed for AST, ALT, and GGT, while alkaline phosphatase significantly decreased and plasma glutathione decreased relative to the alcohol control group. These results suggest that consumption of the proprietary glycyrrhizin study product during alcohol consumption may support improved liver health compared with drinking alcohol alone. Copyright \u00a9 2016 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.5699","type":"journal-article","created":{"date-parts":[[2016,8,19]],"date-time":"2016-08-19T06:56:38Z","timestamp":1471589798000},"page":"1943-1953","source":"Crossref","is-referenced-by-count":32,"title":["Hepatoprotective Effects of a Proprietary Glycyrrhizin Product during Alcohol Consumption: A Randomized, Double\u2010Blind, Placebo\u2010Controlled, Crossover Study"],"prefix":"10.1002","volume":"30","author":[{"given":"Harsha","family":"Chigurupati","sequence":"first","affiliation":[{"name":"Chigurupati Technologies Private Limited Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biswajit","family":"Auddy","sequence":"additional","affiliation":[{"name":"Chigurupati Technologies Private Limited Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Biyani","sequence":"additional","affiliation":[{"name":"Chigurupati Technologies Private Limited Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidney J.","family":"Stohs","sequence":"additional","affiliation":[{"name":"Creighton University 7068 Maumee Valley Court Frisco TX 75034 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.52.1436"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/S0022-3565(25)22134-6","article-title":"Plasma glutathione and glutathione disulfide in the rat: regulation and response to oxidative stress","volume":"227","author":"Adams JD","year":"1983","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agn099"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.314062"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v4.i3.81"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-006-0268-1"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2100107"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf4038419"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1296.59963"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-012-1003-1"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i33.11743"},{"key":"e_1_2_8_13_1","first-page":"24","article-title":"A study of biochemical and hematological markers in alcoholic liver cirrhosis","volume":"2","author":"Deshpande N","year":"2014","journal-title":"World J Nutr Hlth"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i42.11904"},{"key":"e_1_2_8_15_1","first-page":"134","article-title":"Influence of antioxidants (mannitol and allopurinol) on oxygen free radical generation during and after cardiopulmonary bypass","volume":"74","author":"England MD","year":"1996","journal-title":"Circulation"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199001113220205"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1269\/jrr.45.461"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1078\/0940-2993-00175"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2011.151"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0089450"},{"key":"e_1_2_8_21_1","first-page":"1","article-title":"Effect of glycyrrhizin on traumatic brain injury in rats and its mechanism","volume":"17","author":"Gu XJ","year":"2014","journal-title":"Chin J Traumatol"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i1.37"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0812149106"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agh201"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms150915026"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2015.05.053"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1383-5718(01)00214-5"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/3527600752.ch21"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.1.126"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/650514"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5591"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(02)02311-6"},{"key":"e_1_2_8_33_1","first-page":"253","article-title":"Glutathione, a biochemical indicator for different types of cellular oxidative stress. Ethanol poisoning","volume":"97","author":"Jerca L","year":"1993","journal-title":"Rev Med Chir Soc Med Nat Iasi"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-0997-0"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-8490.102260"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.12669\/pjms.315.8025"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i1.8"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5189"},{"key":"e_1_2_8_39_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0022-3565(25)21438-0","article-title":"Ethanol suppresses hepatic glutathione synthesis in rats in vivo","volume":"230","author":"Lauterburg BH","year":"1984","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.29.9.1153"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/60.2.255"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ALC.0000108654.77178.03"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.30.1898"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms161125942"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules17010716"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i17.5271"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v7.i27.2703"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1006\/faat.1994.1005"},{"key":"e_1_2_8_49_1","first-page":"168","article-title":"Free radicals and not acetaldehyde influence the circulating levels of glutathione after acute and chronic alcohol abuse: in vivo and in vitro studies","volume":"29","author":"Loquercio C","year":"1997","journal-title":"Ital J Gastroenterol Hepatol"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1999.tb04073.x"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(12)60005-1"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/41.10.1509"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2012.13.7.3513"},{"key":"e_1_2_8_54_1","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1093\/clinchem\/34.3.525","article-title":"Changes in serum enzymes in moderate drinkers after an alcohol challenge","volume":"34","author":"Nemesanszky E","year":"1988","journal-title":"Clin Chem"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2095-4964(14)60006-6"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agh074"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1177\/2042018812454322"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.593"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2014.07.001"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.2478\/v10102-012-0034-1"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tplants.2016.01.006"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520510023495"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(86)90121-8"},{"key":"e_1_2_8_64_1","first-page":"146","article-title":"Association of alcohol consumption with specific biomarkers: a cross\u2010sectional study in South Africa","volume":"33","author":"Pisa PT","year":"2015","journal-title":"J Health Popul Nutr"},{"key":"e_1_2_8_65_1","first-page":"80","article-title":"Relationship between DDR@ and alcoholic liver fibrosis and responses to compound glycyrrhizin tablets on them: an experimental study","volume":"47","author":"Quan ZY","year":"2009","journal-title":"J Shandong Univ"},{"key":"e_1_2_8_66_1","first-page":"896","article-title":"Alcoholic liver disease. Implications of oxidative stress","volume":"22","author":"Qureshi MS","year":"2015","journal-title":"Prof Med J"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.24.9223"},{"key":"e_1_2_8_68_1","first-page":"97","article-title":"Beneficial effects of hypertonic mannitol in acute ischemia\u2010reperfusion injuries in humans","volume":"4","author":"Shah DM","year":"1996","journal-title":"Vascular"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5359.101809"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-015-2523-y"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.22490"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2008.11.028"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8278(89)90146-3"},{"key":"e_1_2_8_74_1","first-page":"42","article-title":"Inhibitory effect of glycyrrhizin on NF\u2010kappa B binding activity in CCl4 plus ethanol induced liver cirrhosis in rats","volume":"7","author":"Wang J","year":"1999","journal-title":"Zhonghue Gan Zang Bin Za Zhi"},{"key":"e_1_2_8_75_1","first-page":"1377","article-title":"Glycyrrhizic acid nanoparticles inhibit LPS\u2010induced inflammatory mediators in 264.7 mouse macrophages compared with unprocessed glycyrrhizic acid","volume":"8","author":"Wang W","year":"2013","journal-title":"Int J Nanomedicine"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2014-0536"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2015.04.024"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21010064"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12015"},{"key":"e_1_2_8_80_1","article-title":"Protective effects of glycyrrhizic acid and 18\u03b2\u2010glycyrrhetinic acid against cisplatin\u2010induced nephrotoxicity in BALB\/c mice","author":"Wu CH","year":"2015","journal-title":"J Agric Food Chem"},{"key":"e_1_2_8_81_1","first-page":"2981","article-title":"The effects of glycyrrhizin on experimental acute pancreatitis in rats","volume":"17","author":"Yildirim AQ","year":"2013","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5072"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2007.06.017"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2011.09.011"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.3390\/iherph.13040399"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.5699","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.5699","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.5699","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T19:24:35Z","timestamp":1749065075000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.5699"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,19]]},"references-count":84,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.1002\/ptr.5699"],"URL":"https:\/\/doi.org\/10.1002\/ptr.5699","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,19]]}}}