{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T12:55:37Z","timestamp":1760100937104},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,10,7]],"date-time":"2016-10-07T00:00:00Z","timestamp":1475798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"All India Council for Technical Education, New Delhi, India"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>The aim of the study was to investigate the herb\u2013drug interaction of <jats:italic>Andrographis paniculata Nees<\/jats:italic> (Acanthaceae) and Andrographolide (AN) with nabumetone (NAB) in wistar rats. Pharmacokinetic and pharmacodynamic interactions were studied after co\u2010administration of APE and AN with NAB in Wistar rats. In pharmacokinetic studies, significant decrease in Cmax, AUC<jats:sub>0\u2013t<\/jats:sub> and AUC<jats:sub>0\u2013\u221e<\/jats:sub> of 6\u2010MNA after co\u2010administration with pure AN and APE has been observed. T<jats:sub>max<\/jats:sub> of 6\u2010MNA has been increased to 2\u2009h from 1.5\u2009h in AN\u2009+\u2009NAB treated group. Changes in mean residential time, clearance and volume of distribution of 6\u2010MNA in APE\u2009+\u2009NAB treated group and AN\u2009+\u2009NAB treated group indicated interference of other components of APE other than AN. In pharmacodynamic study, significant decrease in antiarthritic activity of NAB on concomitant administration with APE and AN has been observed. The study concludes that NAB exhibits pharmacokinetic and pharmacodynamic interactions with APE and AN in rats thus alarms the concomitant use of herbal preparations containing APE and AN with NAB. Further study is needed to understand the mechanism and predict the herb\u2013drug interaction in humans. Copyright \u00a9 2016 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.5731","type":"journal-article","created":{"date-parts":[[2016,10,13]],"date-time":"2016-10-13T04:22:50Z","timestamp":1476332570000},"page":"75-80","source":"Crossref","is-referenced-by-count":18,"title":["Pharmacokinetic and Pharmacodynamic Interaction of Andrographolide and Standardized Extract of <i>Andrographis paniculata<\/i> (<i>Nees<\/i>) with Nabumetone in Wistar Rats"],"prefix":"10.1002","volume":"31","author":[{"given":"Aishwarya","family":"Balap","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Poona College of Pharmacy Bharati Vidyapeeth, Deemed University (BVDU)  Pune 411 038 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sathiyanarayanan","family":"Lohidasan","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Poona College of Pharmacy Bharati Vidyapeeth, Deemed University (BVDU)  Pune 411 038 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arulmozhi","family":"Sinnathambi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Poona College of Pharmacy Bharati Vidyapeeth Deemed University (BVDU)  Pune 411 038 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kakasaheb","family":"Mahadik","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Poona College of Pharmacy Bharati Vidyapeeth, Deemed University (BVDU)  Pune 411 038 India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/982689"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5193"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/106002809302700413"},{"key":"e_1_2_9_5_1","first-page":"404","article-title":"Clinical pharmacokinetics of nabumetone. 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