{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:06:24Z","timestamp":1790744784490,"version":"4.1.0"},"reference-count":200,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,9,26]],"date-time":"2016-09-26T00:00:00Z","timestamp":1474848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p><jats:italic>Nelumbo nucifera<\/jats:italic>, also known as sacred lotus, has primarily been used as food throughout the Asian continent, and its medicinal values have been described in Ayurvedic and Traditional Chinese Medicine. The purpose of this study is to systematically characterize the chemical profiling and pharmacological activities of <jats:italic>N. nucifera<\/jats:italic>. Herein, we critically reviewed and analysed the phytochemical and pharmacological reports of <jats:italic>N. nucifera<\/jats:italic>. Our search for the keyword \u2018<jats:italic>Nelumbo nucifera<\/jats:italic> pharmacology\u2019 in all databases reported in Web of Science yielded 373 results excluding reviews and abstracts in document types. Two hundred and forty\u2010three spectrum natural compounds from different parts of <jats:italic>N. nucifera<\/jats:italic> belonging to diverse chemical groups, including alkaloids, flavonoids, glycosides, terpenoids, steroids, fatty acids, proteins, minerals, and vitamins have been reported. In addition, distinct pharmacological activities, mainly against cancer, microbial infection, diabetes, inflammation, atherosclerosis, and obesity, have been associated with crude extracts, fractions, and isolated compounds. This review highlights potential use of neferine, liensinine, isoliensinine, and nuciferine in clinical trials. In depth, mechanism of the potential chemical entities from <jats:italic>N. nucifera<\/jats:italic> via structure activity relationship needs to be explored to guarantee the stability and safety for the clinical use<jats:italic>.<\/jats:italic> Copyright \u00a9 2016 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.5732","type":"journal-article","created":{"date-parts":[[2016,9,26]],"date-time":"2016-09-26T05:42:45Z","timestamp":1474868565000},"page":"3-26","source":"Crossref","is-referenced-by-count":185,"title":["A Comprehensive Review on Chemical Profiling of <i>Nelumbo Nucifera<\/i>: Potential for Drug Development"],"prefix":"10.1002","volume":"31","author":[{"given":"Bhesh Raj","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Oriental Medicine Resources, College of Natural Sciences Mokpo National University  61 Muan\u2010gun Jeonnam 534\u2010729 Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lekh Nath S.","family":"Gautam","sequence":"additional","affiliation":[{"name":"C. Eugene Bennett Department of Chemistry West Virginia University  Morgantown WV 26506 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak","family":"Adhikari","sequence":"additional","affiliation":[{"name":"East West College of Pharmacy  Bangalore Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajendra","family":"Karki","sequence":"additional","affiliation":[{"name":"Department of Oriental Medicine Resources, College of Natural Sciences Mokpo National University  61 Muan\u2010gun Jeonnam 534\u2010729 Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,26]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.7324\/JAPS.2015.50419"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2013.04.013"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2013.11.033"},{"key":"e_1_2_5_5_1","first-page":"53","author":"Arthur HR","year":"1959","journal-title":"Aporphine alkaloid nuciferine from a species of lotus cultivated in Hong Kong Chem Abstr"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(96)00880-1"},{"key":"e_1_2_5_7_1","first-page":"147","article-title":"Antimicrobial activity of white and pink Nelumbo nucifera Gaertn flower","volume":"2","author":"Brindha D","year":"2010","journal-title":"JPRHC"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2016.05.012"},{"key":"e_1_2_5_9_1","first-page":"215","article-title":"Studies on the alkaloids of embryo loti, Nelumbo nucifera Gaertn. I. Isolation and characterisation of liensinine","volume":"11","author":"Chao TY","year":"1962","journal-title":"Sci Sin"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/10286020902813957"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2012.676549"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0272.2007.00781.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7262.2008.00342.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X15500159"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2012.02.051"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2011.12.098"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2006.06.016"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.5851\/kosfa.2011.31.1.009"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0008-6215(90)84062-Y"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2012.33.3569"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2013.02.010"},{"key":"e_1_2_5_22_1","first-page":"59","article-title":"Chemical constituents of the seeds of Nelumbo nucifera","volume":"41","author":"Dhar DN","year":"1972","journal-title":"Curr Sci"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2010.10.025"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10528-011-9440-x"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/1423-0127-17-S1-S42"},{"key":"e_1_2_5_26_1","first-page":"4360","article-title":"Studies on flavonoids from stems of Nelumbo nucifera Gaertn and their cytotoxic activities","volume":"39","author":"Duan XH","year":"2014","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"e_1_2_5_27_1","first-page":"4104","article-title":"Cytotoxic alkaloids from stems of Nelumbo nucifera","volume":"38","author":"Duan XH","year":"2013","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.01.039"},{"key":"e_1_2_5_29_1","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1201\/9781420040463","volume-title":"Hand Book of Mediinal Herbs","author":"Duke JA","year":"2002"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0150602"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02888520"},{"key":"e_1_2_5_32_1","first-page":"4","article-title":"Studies of alkaloids of Nelumbo nucifera Gaertn. NMR spectra of liensinine type alkaloids","volume":"86","author":"Furukawa H","year":"1966","journal-title":"J Pharm Soc"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1248\/yakushi1947.85.5_472"},{"key":"e_1_2_5_34_1","article-title":"Composition of the nelumbium speciosum wild seeds","volume":"98","author":"Gangrade HH","year":"1966","journal-title":"Chem Abstr"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.154.3.8810593"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.5b01901"},{"key":"e_1_2_5_37_1","first-page":"291","article-title":"Studies on the alkaloid constituents of the embryo nelumbini., (Nelumbo nucifera) produced in China","volume":"15","author":"Guo M","year":"1984","journal-title":"Zhongcaoyao"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2016.4247"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1515\/jbcpp-2013-0071"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5099"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6101(02)00026-6"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2009.09.033"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf050707a"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1211\/jpp.62.05.0015"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf103382h"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1296209"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02968572"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2013.02.015"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.59.947"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5591"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5FO00201J"},{"key":"e_1_2_5_52_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20100062"},{"key":"e_1_2_5_53_1","doi-asserted-by":"publisher","DOI":"10.3109\/09637480903427913"},{"key":"e_1_2_5_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2016.03.020"},{"key":"e_1_2_5_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.4687"},{"key":"e_1_2_5_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2010.08.005"},{"key":"e_1_2_5_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2008.10.004"},{"key":"e_1_2_5_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-014-0492-4"},{"key":"e_1_2_5_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02976956"},{"key":"e_1_2_5_60_1","first-page":"377","article-title":"The mixture of different parts of Nelumbo nucifera and two bioactive components inhibited tyrosinase activity and melanogenesis","volume":"65","author":"Jung SY","year":"2014","journal-title":"J Cosmet Sci"},{"key":"e_1_2_5_61_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq164"},{"key":"e_1_2_5_62_1","first-page":"103","article-title":"Formulation and sensory evaluation of granule and tablet from lotus rhizome (Nelumbo nucifera Rhizome)","volume":"21","author":"Karki R","year":"2008","journal-title":"Kor J Plant Resour"},{"key":"e_1_2_5_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2012.12.015"},{"key":"e_1_2_5_64_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/153568"},{"key":"e_1_2_5_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2015.01.006"},{"key":"e_1_2_5_66_1","first-page":"96","article-title":"Effect of Nelumbo nucifera on proliferation, migration and expression of MMP\u20102 and MMP\u20109 of rSMC, A431 and MDA\u2010MB\u2010231","volume":"21","author":"Karki R","year":"2008","journal-title":"Kor J Plant Resour"},{"key":"e_1_2_5_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2004.10.020"},{"key":"e_1_2_5_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2015.04.054"},{"key":"e_1_2_5_69_1","first-page":"274","article-title":"Oxalate contents of foods commonly used in Kashmir Indian","volume":"55","author":"Kaul S","year":"1967","journal-title":"J Med Res"},{"key":"e_1_2_5_70_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2015.1055743"},{"key":"e_1_2_5_71_1","first-page":"327","author":"Khare CP","year":"2004","journal-title":"Indian herbal remedies: rational western therapy ayurvedic and other traditional usage Botany Springer science and business meia"},{"key":"e_1_2_5_72_1","first-page":"90","article-title":"Phytochemical constituents of Nelumbo nucifera","volume":"15","author":"Kim KH","year":"2009","journal-title":"Nat Prod Sci"},{"key":"e_1_2_5_73_1","first-page":"1079.30","article-title":"Effects of phytosterols and fatty acids from lotus (Nelumbo nucifera) seed on differentiation of human preadipocytes into adipocytes","volume":"27","author":"Kim SH","year":"2013","journal-title":"FASEB J"},{"key":"e_1_2_5_74_1","doi-asserted-by":"publisher","DOI":"10.3746\/pnf.2015.20.3.162"},{"key":"e_1_2_5_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11814-010-0357-6"},{"key":"e_1_2_5_76_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200501-017PP"},{"key":"e_1_2_5_77_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-9-137"},{"key":"e_1_2_5_78_1","doi-asserted-by":"publisher","DOI":"10.1021\/cg060035w"},{"key":"e_1_2_5_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2009.10.001"},{"key":"e_1_2_5_80_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00217-010-1287-6"},{"key":"e_1_2_5_81_1","first-page":"699","article-title":"Alkaloids of Nelumbo nucifera","volume":"12","author":"Kunitomo J","year":"1973","journal-title":"Phys Chem"},{"key":"e_1_2_5_82_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11373-005-9001-6"},{"key":"e_1_2_5_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/0040-4020(63)80025-3"},{"key":"e_1_2_5_84_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2015.3457"},{"key":"e_1_2_5_85_1","doi-asserted-by":"publisher","DOI":"10.3746\/pnf.2015.20.1.22"},{"key":"e_1_2_5_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2621.2005.00990.x"},{"key":"e_1_2_5_87_1","article-title":"Anti\u2010angiogenic effect of Nelumbo nucifera leaf extracts in human umbilical vein endothelial cells with antioxidant potential","volume":"10","author":"Lee JS","year":"2015","journal-title":"PLoS One"},{"key":"e_1_2_5_88_1","first-page":"328","article-title":"Effects of neferine on transmembrane potential in rabbit sinoatrial nodes and clusters of cultured myocardial cells from neonatal rats","volume":"10","author":"Li GR","year":"1989","journal-title":"Acta Pharmacol Sin"},{"key":"e_1_2_5_89_1","first-page":"158","article-title":"Effects of neferine on heart electromechanical activity in anaesthetized cats","volume":"11","author":"Li GR","year":"1990","journal-title":"Acta Pharmacol Sin"},{"key":"e_1_2_5_90_1","article-title":"Biogenesis of C\u2010glycosyl flavones and profiling of flavonoid glycosides in lotus (Nelumbo nucifera)","volume":"9","author":"Li SS","year":"2014","journal-title":"PLoS One"},{"key":"e_1_2_5_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2010.57"},{"key":"e_1_2_5_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2013.05.018"},{"key":"e_1_2_5_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2013.02.028"},{"key":"e_1_2_5_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1847"},{"key":"e_1_2_5_95_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms15033624"},{"key":"e_1_2_5_96_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf040325p"},{"key":"e_1_2_5_97_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules191117829"},{"key":"e_1_2_5_98_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0106056"},{"key":"e_1_2_5_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2004.01.019"},{"key":"e_1_2_5_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2005.11.062"},{"key":"e_1_2_5_101_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X14500554"},{"key":"e_1_2_5_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2015.02.015"},{"key":"e_1_2_5_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2005.01.066"},{"key":"e_1_2_5_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2012.01.037"},{"key":"e_1_2_5_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2015.07.001"},{"key":"e_1_2_5_106_1","doi-asserted-by":"publisher","DOI":"10.1089\/rej.2012.1380"},{"key":"e_1_2_5_107_1","first-page":"64","article-title":"A comparison of the effects of topical green tea and lotus on facial sebum control in healthy humans","volume":"17","author":"Mahmood T","year":"2013","journal-title":"Hippokratia"},{"key":"e_1_2_5_108_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707224"},{"key":"e_1_2_5_109_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21070930"},{"key":"e_1_2_5_110_1","doi-asserted-by":"publisher","DOI":"10.3109\/08923970903514830"},{"key":"e_1_2_5_111_1","first-page":"268","article-title":"A review on Nelumbo nucifera gaertn","volume":"15","author":"Mukherjee PK","year":"1996","journal-title":"Anc Sci Life"},{"key":"e_1_2_5_112_1","doi-asserted-by":"publisher","DOI":"10.1211\/jpp.61.04.0001"},{"key":"e_1_2_5_113_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-957705"},{"key":"e_1_2_5_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(97)00107-4"},{"key":"e_1_2_5_115_1","first-page":"5","article-title":"Effect of Nelumbo nucifera seeds on the reproductinve organs of female rats","volume":"6","author":"Mutreja A","year":"2008","journal-title":"Iran J Reprod Med"},{"key":"e_1_2_5_116_1","first-page":"176","article-title":"Chemical examination of the flowers of Nelumbium speciosum willd","volume":"35","author":"Nagarajan S","year":"1966","journal-title":"Curr Sci"},{"key":"e_1_2_5_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2012.11.038"},{"key":"e_1_2_5_118_1","first-page":"1527d","article-title":"Medicinal resources XIX. Flavonoid of the leaves of Nelumbo nucifera","volume":"56","author":"Nakaoki T","year":"1962","journal-title":"Chem Abstr"},{"key":"e_1_2_5_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2012.05.024"},{"key":"e_1_2_5_120_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.c12-00820"},{"key":"e_1_2_5_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2013.10.168"},{"key":"e_1_2_5_122_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1537-2197.1926.tb05908.x"},{"key":"e_1_2_5_123_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-990223"},{"key":"e_1_2_5_124_1","doi-asserted-by":"publisher","DOI":"10.1080\/10412905.1991.9697932"},{"key":"e_1_2_5_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.12.036"},{"key":"e_1_2_5_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2009.04.008"},{"key":"e_1_2_5_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2016.04.006"},{"key":"e_1_2_5_128_1","doi-asserted-by":"publisher","DOI":"10.1139\/y11-021"},{"key":"e_1_2_5_129_1","doi-asserted-by":"publisher","DOI":"10.1155\/S1110724302203010"},{"key":"e_1_2_5_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2012.07.112"},{"key":"e_1_2_5_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2013.05.138"},{"key":"e_1_2_5_132_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1115"},{"key":"e_1_2_5_133_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5789857"},{"key":"e_1_2_5_134_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2016.53"},{"key":"e_1_2_5_135_1","first-page":"1086","article-title":"Cardiovascular pharmacological effects of bisbenzylisoquinoline alkaloid derivatives","volume":"23","author":"Qian JQ","year":"2002","journal-title":"Acta Pharmaco Sin"},{"key":"e_1_2_5_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.09.025"},{"key":"e_1_2_5_137_1","first-page":"1276","article-title":"Factors controlling smooth muscle cell proliferation","volume":"116","author":"Reidy MA","year":"1992","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_5_138_1","doi-asserted-by":"publisher","DOI":"10.1038\/362801a0"},{"key":"e_1_2_5_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0254-6272(16)30011-5"},{"key":"e_1_2_5_140_1","first-page":"169256","volume":"2015","author":"Sharma BR","year":"2015","journal-title":"Biomed Res Int"},{"key":"e_1_2_5_141_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X15500421"},{"key":"e_1_2_5_142_1","doi-asserted-by":"publisher","DOI":"10.4014\/jmb.0804.259"},{"key":"e_1_2_5_143_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10068-015-0190-0"},{"key":"e_1_2_5_144_1","doi-asserted-by":"publisher","DOI":"10.1021\/np50052a044"},{"key":"e_1_2_5_145_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.5b02993"},{"key":"e_1_2_5_146_1","volume-title":"Isoliensinine induces dephosphorylation of NF\u2010kB p65 subunit at Ser536 via a PP2A\u2010dependent mechanism in hepatocellular carcinoma cells: roles of impairing PP2A\/I2PP2A interaction","author":"Shu G","year":"2016"},{"key":"e_1_2_5_147_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-7075-7-66"},{"key":"e_1_2_5_148_1","doi-asserted-by":"publisher","DOI":"10.1002\/1099-1573(200006)14:4<272::AID-PTR556>3.0.CO;2-H"},{"key":"e_1_2_5_149_1","doi-asserted-by":"publisher","DOI":"10.1078\/094471103321659889"},{"key":"e_1_2_5_150_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10759"},{"key":"e_1_2_5_151_1","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.12473"},{"key":"e_1_2_5_152_1","first-page":"620c","article-title":"Alkaloids from Nelumbo nucifera","volume":"59","author":"Tomita M","year":"1963","journal-title":"Chem Abstr"},{"key":"e_1_2_5_153_1","first-page":"2564f","article-title":"Alkaloids of Nelumbo nucifera III. Alkaloids of Nelumbo nucifera var, prolifera","volume":"56","author":"Tomita M","year":"1962","journal-title":"Chem Abstr"},{"key":"e_1_2_5_154_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.13.39"},{"key":"e_1_2_5_155_1","doi-asserted-by":"publisher","DOI":"10.1248\/yakushi1947.81.4_469"},{"key":"e_1_2_5_156_1","first-page":"1059f","article-title":"Glutathione in the seed of Nelumbo nucifera","volume":"65","author":"Toyoda K","year":"1966","journal-title":"Chem Abstr"},{"key":"e_1_2_5_157_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-511X-10-202"},{"key":"e_1_2_5_158_1","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.110745"},{"key":"e_1_2_5_159_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5000"},{"key":"e_1_2_5_160_1","doi-asserted-by":"crossref","first-page":"145925","DOI":"10.1155\/2013\/145925","article-title":"Effect of Nelumbo nucifera petal extracts on lipase, adipogenesis, adipolysis, and central receptors of obesity","volume":"2013","author":"Velusami CC","year":"2013","journal-title":"Evid Based Complement Alternat Med"},{"key":"e_1_2_5_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0367-326X(99)00016-7"},{"key":"e_1_2_5_162_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.1535"},{"key":"e_1_2_5_163_1","first-page":"673","article-title":"Alkaloids of plumula Nelumbinis","volume":"16","author":"Wang J","year":"1991","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"e_1_2_5_164_1","first-page":"881","article-title":"Effects of liensinine on haemodynamics in rats and the physiologic properties of isolated rabbit atria","volume":"27","author":"Wang JL","year":"1992","journal-title":"Yao Xue Xue Bao"},{"key":"e_1_2_5_165_1","first-page":"812","article-title":"Effects of linesinine on slow action potentials in myocardium and slow inward current in canine cardiac Purkinje fibers","volume":"28","author":"Wang JL","year":"1993","journal-title":"Yao Xue Xue Bao"},{"key":"e_1_2_5_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2014.11.035"},{"key":"e_1_2_5_167_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13021"},{"key":"e_1_2_5_168_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.3539"},{"key":"e_1_2_5_169_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules20033496"},{"key":"e_1_2_5_170_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf101415v"},{"key":"e_1_2_5_171_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12805"},{"key":"e_1_2_5_172_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu6083230"},{"key":"e_1_2_5_173_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.5b01082"},{"key":"e_1_2_5_174_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2004.05.003"},{"key":"e_1_2_5_175_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-837821"},{"key":"e_1_2_5_176_1","doi-asserted-by":"publisher","DOI":"10.1080\/1028602042000325609"},{"key":"e_1_2_5_177_1","doi-asserted-by":"publisher","DOI":"10.1002\/pca.1196"},{"key":"e_1_2_5_178_1","first-page":"1","article-title":"Neferine induces autophagy of human ovarian cancer cells via p38 MAPK\/ JNK activation","volume":"2016","author":"Xu L","year":"2016","journal-title":"Tumour Biol"},{"key":"e_1_2_5_179_1","first-page":"4619","article-title":"Isolation and characterization of chemical constituents from the petals of Nelumbo nucifera","volume":"24","author":"Xu S","year":"2012","journal-title":"Asian J Chem"},{"key":"e_1_2_5_180_1","first-page":"1244","article-title":"Separation and purification of flavones from Nelumbo nucifera Gaertn. by silica gel chromatography and high\u2010speed counter\u2010current chromatography]","volume":"29","author":"Xu S","year":"2011","journal-title":"Se Pu"},{"key":"e_1_2_5_181_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.5b04141"},{"key":"e_1_2_5_182_1","first-page":"8","article-title":"On the Alkaloids of Nelumbo nucifera Gaertn. Studies on the Alkaoids of Loti Embryo","volume":"17","author":"Yang TH","year":"2013","journal-title":"J Chin Chem Soc"},{"key":"e_1_2_5_183_1","doi-asserted-by":"publisher","DOI":"10.1002\/jccs.197200020"},{"key":"e_1_2_5_184_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2014.02.014"},{"key":"e_1_2_5_185_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.3337"},{"key":"e_1_2_5_186_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2013.03.024"},{"key":"e_1_2_5_187_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.6297"},{"key":"e_1_2_5_188_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2014.01.003"},{"key":"e_1_2_5_189_1","first-page":"1","article-title":"Effects of neferine on platelet aggregation in rabbits.1997","volume":"32","author":"Yu J","year":"1997","journal-title":"Yao Xue Xue Bao"},{"key":"e_1_2_5_190_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2011.12.035"},{"key":"e_1_2_5_191_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep12579"},{"key":"e_1_2_5_192_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11101-015-9401-9"},{"key":"e_1_2_5_193_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2009.11.007"},{"key":"e_1_2_5_194_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf501644t"},{"key":"e_1_2_5_195_1","first-page":"703","article-title":"Chemical constituents from leaves of Nelumbo nucifera","volume":"38","author":"Zhao XL","year":"2013","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"e_1_2_5_196_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.3554"},{"key":"e_1_2_5_197_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5285"},{"key":"e_1_2_5_198_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2014.1952"},{"key":"e_1_2_5_199_1","article-title":"Identification and comparison of anti\u2010inflammatory ingredients from different organs of Lotus nelumbo by UPLC\/Q\u2010TOF and PCA coupled with a NF\u2010kappa B reporter gene assay","volume":"8","author":"Zhou M","year":"2013","journal-title":"PLoS One"},{"key":"e_1_2_5_200_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2015.1056970"},{"key":"e_1_2_5_201_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules200610553"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.5732","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.5732","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.5732","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T22:51:40Z","timestamp":1696459900000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.5732"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,26]]},"references-count":200,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1002\/ptr.5732"],"URL":"https:\/\/doi.org\/10.1002\/ptr.5732","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,26]]}}}