{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:08:45Z","timestamp":1785802125540,"version":"3.56.0"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,10,17]],"date-time":"2016-10-17T00:00:00Z","timestamp":1476662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p><jats:italic>Citrus bergamia<\/jats:italic>Risso et Poiteau (\u201cBergamot\u201d) originated from the Mediterranean ecoregion (southern Italy, Calabria). Bergamot essential oil (BEO) is used in perfumes, cosmetics, and for stress reduction. Juice from<jats:italic>C.\u2009bergamia<\/jats:italic>has been used for hyperlipidemia. We evaluated literature published on<jats:italic>C.\u2009bergamia<\/jats:italic>clinical applications. Clinical trials on<jats:italic>C.\u2009bergamia<\/jats:italic>not combined with other substances, published in English, were searched. We selected ten articles, six describing BEO effects on stress, three reporting effects of polyphenolic fraction of<jats:italic>C.\u2009bergamia<\/jats:italic>juice in hyperlipidemia and the last describing BEO effects in chronic psoriasis. Clinical studies were analyzed following Consolidated Standards of Reporting Trials for herbal therapy. Studies were conducted on small sample sizes and not have high quality level. Analysis indicates that BEO aromatherapy could be safe and useful to reduce stress symptoms. One study suggests its potential supportive role in ultraviolet B therapy against psoriasis. Supplementation with polyphenols from bergamot juice reduces plasma lipids and improves lipoprotein profile in moderate hyperlipidemia. Effectiveness and safety of<jats:italic>C.\u2009bergamia<\/jats:italic>cannot be definitively drawn because of publication bias and low quality level of the majority of studies. Further large\u2010scale trials with rigorous design are required to define the role of<jats:italic>C.\u2009bergamia<\/jats:italic>in clinical practice. Copyright \u00a9 2016 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.5734","type":"journal-article","created":{"date-parts":[[2016,10,17]],"date-time":"2016-10-17T08:21:19Z","timestamp":1476692479000},"page":"27-39","source":"Crossref","is-referenced-by-count":84,"title":["Clinical Pharmacology of<scp><i>Citrus bergamia<\/i><\/scp>: A Systematic Review"],"prefix":"10.1002","volume":"31","author":[{"given":"Carmen","family":"Mannucci","sequence":"first","affiliation":[{"name":"Department of Biomedical and Dental Sciences and Morphofunctional Imaging University of Messina Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Navarra","sequence":"additional","affiliation":[{"name":"Department of Chemical, Biological, Pharmaceutical and Environmental Sciences University of Messina Messina 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