{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T04:23:40Z","timestamp":1783571020487,"version":"3.55.0"},"reference-count":53,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,11,3]],"date-time":"2016-11-03T00:00:00Z","timestamp":1478131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Vice-Chancellor for Research Affairs of Ahvaz Jundishapur University of Medical Sciences","award":["NRC-9304"],"award-info":[{"award-number":["NRC-9304"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>The aim of this study was to investigate the impact of resveratrol supplementation along with non\u2010surgical periodontal treatment on blood glucose, insulin, insulin resistance, triglyceride (TG), and periodontal markers in patients with type 2 diabetes with periodontal disease. In this double\u2010blind clinical trial study, 43 patients with diabetes with chronic periodontitis were participated. Subjects were randomly allocated to intervention and control groups. The intervention and control groups received either 480\u2009mg\/day of resveratrol or placebo capsules (two pills) for 4\u2009weeks. Fasting blood glucose, insulin, insulin resistance (homeostasis model assessment of insulin resistance), TGs, and pocket depth were measured in all subjects' pre\u2010intervention and post\u2010intervention. The mean serum levels of fasting insulin and insulin resistance (homeostasis model assessment of insulin resistance) were significantly lower in the intervention group compared with control group (10.42\u2009\u00b1\u20090.28 and 10.92\u2009\u00b1\u20090.9; 3.66\u2009\u00b1\u20090.97 and 4.49\u2009\u00b1\u20091.56, respectively). There was a significant difference in the mean pocket depth between intervention and control groups (2.35\u2009\u00b1\u20090.6 and 3.38\u2009\u00b1\u20090.5, respectively) following intervention. No significant differences were observed in the mean levels of fasting blood glucose and TGs between two groups' post\u2010intervention. It is recommended that resveratrol supplementation may be beneficial as adjuvant therapy along with non\u2010surgical periodontal treatment in insulin resistance and improving periodontal status among patients with diabetes with periodontal disease. Copyright \u00a9 2016 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.5737","type":"journal-article","created":{"date-parts":[[2016,11,3]],"date-time":"2016-11-03T05:43:30Z","timestamp":1478151810000},"page":"108-114","source":"Crossref","is-referenced-by-count":95,"title":["The Impact of Resveratrol Supplementation on Blood Glucose, Insulin, Insulin Resistance, Triglyceride, and Periodontal Markers in Type 2 Diabetic Patients with Chronic Periodontitis"],"prefix":"10.1002","volume":"31","author":[{"given":"Ahmad","family":"Zare Javid","sequence":"first","affiliation":[{"name":"Nutrition and Metabolic Diseases Research Center and Hyperlipidemia Research Center Ahvaz Jundishapur University of Medical Sciences  Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Razie","family":"Hormoznejad","sequence":"additional","affiliation":[{"name":"Health Research Institute, Diabetes Research Center Ahvaz Jundishapur University of Medical Sciences  Ahvaz 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