{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T11:09:26Z","timestamp":1762340966173,"version":"3.41.0"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,1,9]],"date-time":"2017-01-09T00:00:00Z","timestamp":1483920000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"},{"start":{"date-parts":[[2017,1,9]],"date-time":"2017-01-09T00:00:00Z","timestamp":1483920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions"}],"funder":[{"DOI":"10.13039\/501100004084","name":"Korea Science and Engineering Foundation","doi-asserted-by":"publisher","award":["2014R1A2A10052872"],"award-info":[{"award-number":["2014R1A2A10052872"]}],"id":[{"id":"10.13039\/501100004084","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytother. Res."],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1002\/ptr.5763","type":"journal-article","created":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T04:56:57Z","timestamp":1484024217000},"page":"418-424","source":"Crossref","is-referenced-by-count":8,"title":["Anti-rheumatoid Arthritis Effect of Kaejadan via Analgesic and Antiinflammatory Activity<i>in vivo<\/i>and<i>in vitro<\/i>"],"prefix":"10.1002","volume":"31","author":[{"given":"Jung Jae","family":"Yoon","sequence":"first","affiliation":[{"name":"College of Korean Medicine; Kyung Hee University; 1 Hoegidong, Dongdaemungu Seoul 131-701 Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Jung","family":"Sohn","sequence":"additional","affiliation":[{"name":"College of Korean Medicine; Kyung Hee University; 1 Hoegidong, Dongdaemungu Seoul 131-701 Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Hyo","family":"Kim","sequence":"additional","affiliation":[{"name":"Chosun Nursing College; Gwang-Ju 501-759 Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jai Wha","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of East-West Medicine, Graduate School of East-West Medical Science; Kyung Hee University; Yongin 446-701 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Korean Medicine; Kyung Hee University; 1 Hoegidong, Dongdaemungu Seoul 131-701 Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,1,9]]},"reference":[{"key":"10.1002\/ptr.5763-BIB0001|ptr5763-cit-0001","first-page":"669","article-title":"Inhibition of the \u201ctail-flick\u201d reaction by arecoline and oxotremorin on decerebrated and medullotomized rats","volume":"23","author":"Andreas","year":"1969","journal-title":"Acta Biol Med Ger"},{"key":"10.1002\/ptr.5763-BIB0002|ptr5763-cit-0002","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1476-5381.1983.tb10504.x","article-title":"Studies on the antinociceptive action of alpha-agonist drugs and their interactions with opioid mechanisms","volume":"79","author":"Bentley","year":"1983","journal-title":"Br J Pharmacol"},{"key":"10.1002\/ptr.5763-BIB0003|ptr5763-cit-0003","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD002948.pub2","article-title":"Herbal therapy for treating rheumatoid arthritis","volume":"16","author":"Cameron","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1002\/ptr.5763-BIB0004|ptr5763-cit-0004","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1093\/rheumatology\/keq343","article-title":"Risk of adverse events including serious infections in rheumatoid arthritis patients treated with tocilizumab: a systematic literature review and meta-analysis of randomized controlled trials","volume":"50","author":"Campbell","year":"2011","journal-title":"Rheumatology (Oxford)"},{"key":"10.1002\/ptr.5763-BIB0005|ptr5763-cit-0005","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/j.pmrj.2009.07.002","article-title":"Pain after spinal cord injury: a review of classification, treatment approaches, and treatment assessment","volume":"1","author":"Cardenas","year":"2009","journal-title":"PM R"},{"key":"10.1002\/ptr.5763-BIB0007|ptr5763-cit-0007","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1139\/cjpp-2012-0268","article-title":"The antioxidant resveratrol down-regulates inflammation in an in-vitro model of pseudomonas aeruginosa infection of lung epithelial cells","volume":"91","author":"Cerqueira","year":"2013","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1002\/ptr.5763-BIB0008|ptr5763-cit-0008","doi-asserted-by":"crossref","DOI":"10.1378\/chest.123.3_suppl.446S-a","article-title":"Inhibition of airway inflammation and hyperreactivity by a catalytic antioxidant","volume":"123","author":"Chang","year":"2003","journal-title":"Chest"},{"key":"10.1002\/ptr.5763-BIB0009|ptr5763-cit-0009","doi-asserted-by":"crossref","first-page":"288","DOI":"10.2174\/138945011794815347","article-title":"Natural products triggering biological targets - a review of the anti-inflammatory phytochemicals targeting the arachidonic acid pathway in allergy asthma and rheumatoid arthritis","volume":"12","author":"Chen","year":"2011","journal-title":"Curr Drug Targets"},{"key":"10.1002\/ptr.5763-BIB0010|ptr5763-cit-0010","doi-asserted-by":"crossref","first-page":"957","DOI":"10.2165\/00003495-200059040-00017","article-title":"Celecoxib: a review of its use in osteoarthritis, rheumatoid arthritis and acute pain","volume":"59","author":"Clemett","year":"2000","journal-title":"Drugs"},{"key":"10.1002\/ptr.5763-BIB0011|ptr5763-cit-0011","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0031-6997(24)01484-4","article-title":"Antioxidant therapy: a new pharmacological approach in shock, inflammation, and ischemia\/reperfusion injury","volume":"53","author":"Cuzzocrea","year":"2001","journal-title":"Pharmacol Rev"},{"key":"10.1002\/ptr.5763-BIB0012|ptr5763-cit-0012","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jbspin.2012.02.005","article-title":"Mortality in rheumatoid arthritis over the last fifty years: systematic review and meta-analysis","volume":"80","author":"Dadoun","year":"2013","journal-title":"Joint Bone Spine"},{"key":"10.1002\/ptr.5763-BIB0013|ptr5763-cit-0013","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1185\/03007995.2010.549805","article-title":"Review of treatment response in rheumatoid arthritis: assessment of heterogeneity","volume":"27","author":"Goetz","year":"2011","journal-title":"Curr Med Res Opin"},{"key":"10.1002\/ptr.5763-BIB0014|ptr5763-cit-0014","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1136\/ard.2009.127332","article-title":"Current evidence for the management of rheumatoid arthritis with glucocorticoids: a systematic literature review informing the EULAR recommendations for the management of rheumatoid arthritis","volume":"69","author":"Gorter","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"10.1002\/ptr.5763-BIB0015|ptr5763-cit-0015","doi-asserted-by":"crossref","first-page":"191","DOI":"10.3109\/08923973.2011.590499","article-title":"Analgesic and anti-inflammatory effects of ethyl acetate fraction of Polygonum cuspidatum in experimental animals","volume":"34","author":"Han","year":"2012","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"10.1002\/ptr.5763-BIB0016|ptr5763-cit-0016","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1248\/bpb.30.928","article-title":"Protection of human keratinocytes from UVB-induced inflammation using root extract of Lithospermum erythrorhizon","volume":"30","author":"Ishida","year":"2007","journal-title":"Biol Pharm Bull"},{"key":"10.1002\/ptr.5763-BIB0017|ptr5763-cit-0017","first-page":"399","article-title":"Postoperative analgesia in infants and children: new developments","volume":"70","author":"Ivani","year":"2004","journal-title":"Minerva Anestesiol"},{"key":"10.1002\/ptr.5763-BIB0018|ptr5763-cit-0018","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1017\/S002221511000263X","article-title":"Antioxidant effect of pomegranate extract in reducing acute inflammation due to myringotomy","volume":"125","author":"Kahya","year":"2011","journal-title":"J Laryngol Otol"},{"key":"10.1002\/ptr.5763-BIB0019|ptr5763-cit-0019","first-page":"46","article-title":"Traditional herbal medicines (Kampo) for patients with rheumatoid arthritis receiving concomitant methotrexate: a preliminary study","volume":"16","author":"Kogure","year":"2010","journal-title":"Altern Ther Health Med"},{"key":"10.1002\/ptr.5763-BIB0020|ptr5763-cit-0020","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jdermsci.2009.07.001","article-title":"Anti-inflammatory and barrier protecting effect of Lithospermum erythrorhizon extracts in chronic oxazolone-induced murine atopic dermatitis","volume":"56","author":"Lee","year":"2009","journal-title":"J Dermatol Sci"},{"key":"10.1002\/ptr.5763-BIB0021|ptr5763-cit-0021","doi-asserted-by":"crossref","first-page":"8783","DOI":"10.1016\/j.biortech.2008.04.041","article-title":"Anti-inflammation activity of fruit essential oil from Cinnamomum insularimontanum Hayata","volume":"99","author":"Lin","year":"2008","journal-title":"Bioresour Technol"},{"issue":"1","key":"10.1002\/ptr.5763-BIB0022|ptr5763-cit-0022","article-title":"Herbal therapy for treating rheumatoid arthritis","author":"Little","year":"2001","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1002\/ptr.5763-BIB0023|ptr5763-cit-0023","doi-asserted-by":"crossref","first-page":"428","DOI":"10.3736\/jintegrmed2013059","article-title":"Chinese herbal medicine Xinfeng capsule in treatment of rheumatoid arthritis: study protocol of a multicenter randomized controlled trial","volume":"11","author":"Liu","year":"2013","journal-title":"J Integr Med"},{"key":"10.1002\/ptr.5763-BIB0024|ptr5763-cit-0024","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1093\/rheumatology\/ker119","article-title":"Evidence for the efficacy of complementary and alternative medicines in the management of rheumatoid arthritis: a systematic review","volume":"50","author":"Macfarlane","year":"2011","journal-title":"Rheumatology (Oxford)"},{"key":"10.1002\/ptr.5763-BIB0025|ptr5763-cit-0025","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1432-1033.1974.tb03714.x","article-title":"Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase","volume":"47","author":"Marklund","year":"1974","journal-title":"Eur J Biochem"},{"key":"10.1002\/ptr.5763-BIB0026|ptr5763-cit-0026","first-page":"115","article-title":"Carrageenan-induced paw edema in the rat and mouse","volume":"225","author":"Morris","year":"2003","journal-title":"Methods Mol Biol"},{"key":"10.1002\/ptr.5763-BIB0027|ptr5763-cit-0027","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1136\/ard.2009.126573","article-title":"Current evidence for the management of rheumatoid arthritis with biological disease-modifying antirheumatic drugs: a systematic literature review informing the EULAR recommendations for the management of RA","volume":"69","author":"Nam","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"10.1002\/ptr.5763-BIB0029|ptr5763-cit-0029","doi-asserted-by":"crossref","first-page":"I","DOI":"10.7326\/0003-4819-151-4-200908180-00005","article-title":"The Chinese herbal remedy Tripterygium wilfordii Hook F in the treatment of rheumatoid arthritis","volume":"151","author":"Goldbach-Mansky MW","year":"2009","journal-title":"Ann Intern Med"},{"key":"10.1002\/ptr.5763-BIB0030|ptr5763-cit-0030","doi-asserted-by":"crossref","first-page":"567","DOI":"10.3797\/scipharm.1301-16","article-title":"Ameliorative effects of a polyphenolic fraction of Cinnamomum zeylanicum L. Bark in animal models of inflammation and arthritis","volume":"81","author":"Rathi","year":"2013","journal-title":"Sci Pharm"},{"key":"10.1002\/ptr.5763-BIB0031|ptr5763-cit-0031","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3164\/jcbn.2007002","article-title":"Indian herbal medicines: possible potent therapeutic agents for rheumatoid arthritis","volume":"41","author":"Rathore","year":"2007","journal-title":"J Clin Biochem Nutr"},{"key":"10.1002\/ptr.5763-BIB0032|ptr5763-cit-0032","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2203\/dose-response.10-002.Siddique","article-title":"Estimation of lipid peroxidation induced by hydrogen peroxide in cultured human lymphocytes","volume":"10","author":"Siddique","year":"2012","journal-title":"Dose-response : a publication of International Hormesis Society"},{"key":"10.1002\/ptr.5763-BIB0033|ptr5763-cit-0033","first-page":"601","article-title":"Acetic acid and phenylquinone writhing test: a critical study in mice","volume":"5","author":"Singh","year":"1983","journal-title":"Methods Find Exp Clin Pharmacol"},{"key":"10.1002\/ptr.5763-BIB0034|ptr5763-cit-0034","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.jada.2010.02.010","article-title":"Effectiveness and safety of dietary interventions for rheumatoid arthritis: a systematic review of randomized controlled trials","volume":"110","author":"Smedslund","year":"2010","journal-title":"J Am Diet Assoc"},{"key":"10.1002\/ptr.5763-BIB0035|ptr5763-cit-0035","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1093\/rheumatology\/keg183","article-title":"Herbal medicines for the treatment of rheumatoid arthritis: a systematic review","volume":"42","author":"Soeken","year":"2003","journal-title":"Rheumatology (Oxford)"},{"key":"10.1002\/ptr.5763-BIB0036|ptr5763-cit-0036","doi-asserted-by":"crossref","first-page":"3908","DOI":"10.1016\/j.biortech.2007.07.050","article-title":"Anti-inflammation activities of essential oil and its constituents from indigenous cinnamon (Cinnamomum osmophloeum) twigs","volume":"99","author":"Tung","year":"2008","journal-title":"Bioresour Technol"},{"key":"10.1002\/ptr.5763-BIB0037|ptr5763-cit-0037","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1142\/S0192415X13500742","article-title":"Salvia miltiorrhiza (dan shen) significantly ameliorates colon inflammation in dextran sulfate sodium induced colitis","volume":"41","author":"Wen","year":"2013","journal-title":"Am J Chin Med"},{"key":"10.1002\/ptr.5763-BIB0038|ptr5763-cit-0038","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/j.1476-5381.1964.tb02030.x","article-title":"The use of changes in capillary permeability in mice to distinguish between narcotic and nonnarcotic alalgesics","volume":"22","author":"Whittle","year":"1964","journal-title":"Br J Pharmacol Chemother"},{"key":"10.1002\/ptr.5763-BIB0039|ptr5763-cit-0039","doi-asserted-by":"crossref","first-page":"3742","DOI":"10.1172\/JCI45178","article-title":"What is this thing called pain?","volume":"120","author":"Woolf","year":"2010","journal-title":"J Clin Invest"},{"key":"10.1002\/ptr.5763-BIB0040|ptr5763-cit-0040","first-page":"58","article-title":"The variability of TCM pattern diagnosis and herbal prescription on rheumatoid arthritis patients","volume":"10","author":"Zhang","year":"2004","journal-title":"Altern Ther Health Med"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.5763","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/ptr.5763","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T04:48:19Z","timestamp":1749876499000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.5763"}},"subtitle":["Anti-rheumatoid Arthritis Effect of Kaejadan"],"short-title":[],"issued":{"date-parts":[[2017,1,9]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"URL":"https:\/\/doi.org\/10.1002\/ptr.5763","archive":["Portico"],"relation":{},"ISSN":["0951-418X"],"issn-type":[{"type":"print","value":"0951-418X"}],"subject":[],"published":{"date-parts":[[2017,1,9]]}}}