{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T03:07:09Z","timestamp":1792292829544,"version":"4.4.0"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,1,12]],"date-time":"2017-01-12T00:00:00Z","timestamp":1484179200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"},{"start":{"date-parts":[[2017,1,12]],"date-time":"2017-01-12T00:00:00Z","timestamp":1484179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytother. Res."],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1002\/ptr.5765","type":"journal-article","created":{"date-parts":[[2017,1,12]],"date-time":"2017-01-12T15:24:45Z","timestamp":1484234685000},"page":"433-440","source":"Crossref","is-referenced-by-count":25,"title":["Anti-HCV Activity from Semi-purified Methanolic Root Extracts of<i>Valeriana wallichii<\/i>"],"prefix":"10.1002","volume":"31","author":[{"given":"Krishna Kumar","family":"Ganta","sequence":"first","affiliation":[{"name":"Functional Genomics Lab, Centre for Advanced Study, Department of Botany; University of Calcutta; 35, Ballygunge Circular Road Kolkata 700019 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anirban","family":"Mandal","sequence":"additional","affiliation":[{"name":"Functional Genomics Lab, Centre for Advanced Study, Department of Botany; University of Calcutta; 35, Ballygunge Circular Road Kolkata 700019 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sukalyani","family":"Debnath","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology; Jadavpur University; Kolkata 700032 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banasri","family":"Hazra","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology; Jadavpur University; Kolkata 700032 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2198-6238","authenticated-orcid":false,"given":"Binay","family":"Chaubey","sequence":"additional","affiliation":[{"name":"Functional Genomics Lab, Centre for Advanced Study, Department of Botany; University of Calcutta; 35, Ballygunge Circular Road Kolkata 700019 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,12]]},"reference":[{"issue":"7","key":"10.1002\/ptr.5765-BIB0001|ptr5765-cit-0002","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1021\/ed074p857","article-title":"Medicines and drugs from plants","volume":"74","author":"Agosta","year":"1997","journal-title":"J Chem Educ"},{"issue":"1","key":"10.1002\/ptr.5765-BIB0002|ptr5765-cit-0003","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0166-3542(01)00164-4","article-title":"Novel cell culture systems for the hepatitis C virus","volume":"52","author":"Bartenschlager","year":"2001","journal-title":"Antiviral Res"},{"issue":"6","key":"10.1002\/ptr.5765-BIB0046|ptr5765-cit-0047","doi-asserted-by":"crossref","first-page":"3868","DOI":"10.1074\/jbc.M209785200","article-title":"Characterization of the metal ion binding properties of the hepatitis C virus RNA polymerase","volume":"278","author":"Bougie","year":"2003","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1002\/ptr.5765-BIB0003|ptr5765-cit-0004","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0166-3542(03)00028-7","article-title":"Approaching a new era for hepatitis C virus therapy: inhibitors of the NS3-4A serine protease and the NS5B RNA-dependent RNA polymerase","volume":"58","author":"De Francesco","year":"2003","journal-title":"Antiviral Res"},{"issue":"6","key":"10.1002\/ptr.5765-BIB0004|ptr5765-cit-0005","doi-asserted-by":"crossref","first-page":"801","DOI":"10.2165\/00003495-199754060-00003","article-title":"The role of plant-derived drugs and herbal medicines in healthcare","volume":"54","author":"De Smet","year":"1997","journal-title":"Drugs"},{"key":"10.1002\/ptr.5765-BIB0005|ptr5765-cit-0006","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/0471143030.cb0403s69","article-title":"Immunofluorescence Staining","volume":"69","author":"Donaldson","year":"2015","journal-title":"Curr Protoc Cell Biol"},{"issue":"SUPPL. 52","key":"10.1002\/ptr.5765-BIB0006|ptr5765-cit-0007","first-page":"6.2:6.2.1","article-title":"Immunoblotting and immunodetection","volume":"Chapter 6","author":"Gallagher","year":"2011","journal-title":"Curr Protoc Cell Biol"},{"issue":"4","key":"10.1002\/ptr.5765-BIB0007|ptr5765-cit-0008","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1007\/s00436-010-2127-0","article-title":"Valeriana wallichii root extracts and fractions with activity against Leishmania spp","volume":"108","author":"Ghosh","year":"2011","journal-title":"Parasitol Res"},{"issue":"3","key":"10.1002\/ptr.5765-BIB0008|ptr5765-cit-0009","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.jep.2005.05.010","article-title":"Antispasmodic and blood pressure lowering effects of Valeriana wallichii are mediated through K+ channel activation","volume":"100","author":"Gilani","year":"2005","journal-title":"J Ethnopharmacol"},{"issue":"2","key":"10.1002\/ptr.5765-BIB0010|ptr5765-cit-0011","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.3390\/molecules19021394","article-title":"Antileishmanial lead structures from nature: analysis of structure-activity relationships of a compound library derived from caffeic acid bornyl ester","volume":"19","author":"Glaser","year":"2014","journal-title":"Molecules"},{"issue":"4","key":"10.1002\/ptr.5765-BIB0011|ptr5765-cit-0012","doi-asserted-by":"crossref","first-page":"5740","DOI":"10.3390\/molecules20045740","article-title":"Antileishmanial and cytotoxic compounds from Valeriana wallichii and identification of a novel nepetolactone derivative","volume":"20","author":"Glaser","year":"2015","journal-title":"Molecules"},{"key":"10.1002\/ptr.5765-BIB0012|ptr5765-cit-0013","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.jhep.2011.02.011","article-title":"Naringenin inhibits the assembly and long-term production of infectious hepatitis C virus particles through a PPAR-mediated mechanism","volume":"55","author":"Goldwasser","year":"2011","journal-title":"J Hepatol"},{"issue":"2","key":"10.1002\/ptr.5765-BIB0013|ptr5765-cit-0014","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/laban0205-39","article-title":"Cell culture models and animal models of viral hepatitis. Part II: hepatitis C","volume":"34","author":"Guha","year":"2005","journal-title":"Lab Anim (NY)"},{"issue":"4","key":"10.1002\/ptr.5765-BIB0014|ptr5765-cit-0015","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1021\/np060567e","article-title":"Anti-HCV bioactivity of pseudoguaianolides from Parthenium hispitum","volume":"70","author":"Hu","year":"2007","journal-title":"J Nat Prod"},{"issue":"1","key":"10.1002\/ptr.5765-BIB0015|ptr5765-cit-0016","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.pep.2006.02.011","article-title":"Development of the system ensuring a high-level expression of hepatitis C virus nonstructural NS5B and NS5A proteins","volume":"48","author":"Ivanov","year":"2006","journal-title":"Protein Expr Purif"},{"issue":"9","key":"10.1002\/ptr.5765-BIB0016|ptr5765-cit-0017","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s40267-015-0232-y","article-title":"Ledipasvir\/sofosbuvir in chronic hepatitis C: a guide to its use in the EU","volume":"31","author":"Keating","year":"2015a","journal-title":"Drugs & Therapy Perspectives"},{"key":"10.1002\/ptr.5765-BIB0017|ptr5765-cit-0018","doi-asserted-by":"crossref","unstructured":"Keating , GM 2015b Ledipasvir\/sofosbuvir: a review of its use in chronic hepatitis C","DOI":"10.1007\/s40265-015-0381-2"},{"key":"10.1002\/ptr.5765-BIB0009|ptr5765-cit-0010","doi-asserted-by":"crossref","first-page":"4.0:4.0.1","DOI":"10.1002\/0471142727.mb0400s98","article-title":"Preparation and Analysis of RNA","volume":"98","author":"Kingston","year":"2012","journal-title":"Curr Protoc Mol Biol"},{"issue":"1","key":"10.1002\/ptr.5765-BIB0018|ptr5765-cit-0019","first-page":"14","article-title":"Viral infectious disease and natural products with antiviral activity","volume":"1","author":"Kitazato","year":"2007","journal-title":"Drug Discov Ther"},{"issue":"6","key":"10.1002\/ptr.5765-BIB0019|ptr5765-cit-0020","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1093\/jac\/dkn085","article-title":"Existence of hepatitis C virus NS5B variants naturally resistant to non-nucleoside, but not to nucleoside, polymerase inhibitors among untreated patients","volume":"61","author":"Le Pogam","year":"2008","journal-title":"J Antimicrob Chemother"},{"issue":"5734","key":"10.1002\/ptr.5765-BIB0020|ptr5765-cit-0021","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1126\/science.1114016","article-title":"Complete replication of hepatitis C virus in cell culture","volume":"309","author":"Lindenbach","year":"2005","journal-title":"Science"},{"issue":"1","key":"10.1002\/ptr.5765-BIB0021|ptr5765-cit-0022","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/ptr.5518","article-title":"A phase I dose escalation study demonstrates quercetin safety and explores potential for bioflavonoid antivirals in patients with chronic hepatitis C","volume":"30","author":"Lu","year":"2016","journal-title":"Phytother Res"},{"issue":"49","key":"10.1002\/ptr.5765-BIB0022|ptr5765-cit-0023","doi-asserted-by":"crossref","first-page":"46094","DOI":"10.1074\/jbc.C100349200","article-title":"Hepatitis C virus RNA-dependent RNA polymerase (NS5B) as a mediator of the antiviral activity of ribavirin","volume":"276","author":"Maag","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1002\/ptr.5765-BIB0023|ptr5765-cit-0024","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/9671031","article-title":"Combinations of siRNAs against La Autoantigen with NS5B or hVAP-A have additive effect on inhibition of HCV replication","volume":"2016","author":"Mandal","year":"2016","journal-title":"Hepat Res Treat"},{"issue":"8","key":"10.1002\/ptr.5765-BIB0024|ptr5765-cit-0025","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/nrd4050","article-title":"Novel therapies for hepatitis C - one pill fits all?","volume":"12","author":"Manns","year":"2013","journal-title":"Nat Rev Drug Discov"},{"issue":"9","key":"10.1002\/ptr.5765-BIB0025|ptr5765-cit-0026","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1136\/gut.2005.076646","article-title":"Treating viral hepatitis C: efficacy, side effects, and complications","volume":"55","author":"Manns","year":"2006","journal-title":"Gut"},{"issue":"3","key":"10.1002\/ptr.5765-BIB0026|ptr5765-cit-0027","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.jep.2012.09.036","article-title":"Identification and evaluation of anti hepatitis C virus phytochemicals from Eclipta alba","volume":"144","author":"Manvar","year":"2012","journal-title":"J Ethnopharmacol"},{"issue":"3","key":"10.1002\/ptr.5765-BIB0027|ptr5765-cit-0028","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0091-3057(03)00121-7","article-title":"6-Methylapigenin and hesperidin: new valeriana flavonoids with activity on the CNS","volume":"75","author":"Marder","year":"2003","journal-title":"Pharmacol Biochem Behav"},{"issue":"6","key":"10.1002\/ptr.5765-BIB0028|ptr5765-cit-0029","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1080\/10412905.2005.9699029","article-title":"Valeriana wallichii DC, a new chemotype from northwestern Himalaya","volume":"17","author":"Mathela","year":"2005","journal-title":"J Essent Oil Res"},{"issue":"6","key":"10.1002\/ptr.5765-BIB0029|ptr5765-cit-0030","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nrmicro1645","article-title":"Replication of hepatitis C virus","volume":"5","author":"Moradpour","year":"2007","journal-title":"Nat Rev Microbiol"},{"issue":"1-2","key":"10.1002\/ptr.5765-BIB0030|ptr5765-cit-0031","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J Immunol Methods"},{"issue":"20","key":"10.1002\/ptr.5765-BIB0031|ptr5765-cit-0032","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1016\/S0960-894X(02)00624-8","article-title":"New Rev-transport inhibitor with anti-HIV activity from Valerianae Radix","volume":"12","author":"Murakami","year":"2002","journal-title":"Bioorg Med Chem Lett"},{"issue":"1","key":"10.1002\/ptr.5765-BIB0032|ptr5765-cit-0033","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1177\/2040622310384308","article-title":"Pegylated interferon and ribavirin treatment for hepatitis C virus infection","volume":"2","author":"Palumbo","year":"2011","journal-title":"Ther Adv Chronic Dis"},{"issue":"13","key":"10.1002\/ptr.5765-BIB0033|ptr5765-cit-0034","doi-asserted-by":"crossref","first-page":"5995","DOI":"10.1073\/pnas.0914009107","article-title":"Identification of hepatoprotective flavonolignans from silymarin","volume":"107","author":"Polyak","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"10.1002\/ptr.5765-BIB0034|ptr5765-cit-0035","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3851\/IMP2402","article-title":"Silymarin for HCV infection","volume":"18","author":"Polyak","year":"2013","journal-title":"Antivir Ther"},{"issue":"13","key":"10.1002\/ptr.5765-BIB0035|ptr5765-cit-0036","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1056\/NEJMoa1010494","article-title":"Boceprevir for untreated chronic HCV genotype 1 infection","volume":"364","author":"Poordad","year":"2011","journal-title":"N Engl J Med"},{"issue":"10","key":"10.1002\/ptr.5765-BIB0036|ptr5765-cit-0037","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.3390\/v2102169","article-title":"Inhibitors of the Hepatitis C virus RNA-dependent RNA polymerase NS5B","volume":"2","author":"Powdrill","year":"2010","journal-title":"Viruses"},{"issue":"6","key":"10.1002\/ptr.5765-BIB0037|ptr5765-cit-0038","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/j.jhep.2009.01.019","article-title":"Hepatitis C virus genotype 1b as a risk factor for hepatocellular carcinoma development: a meta-analysis","volume":"50","author":"Raimondi","year":"2009","journal-title":"J Hepatol"},{"issue":"2","key":"10.1002\/ptr.5765-BIB0038|ptr5765-cit-0039","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.jhep.2008.11.010","article-title":"Treatment failure in hepatitis C: mechanisms of non-response","volume":"50","author":"Tai","year":"2009","journal-title":"J Hepatol"},{"issue":"4","key":"10.1002\/ptr.5765-BIB0039|ptr5765-cit-0040","first-page":"211","article-title":"Hepatitis C and liver transplantation","volume":"13","author":"Tsoulfas","year":"2009","journal-title":"Hippokratia"},{"key":"10.1002\/ptr.5765-BIB0040|ptr5765-cit-0041","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1186\/1743-422X-10-245","article-title":"In vitro antiviral activity of plant extracts from Asteraceae medicinal plants","volume":"10","author":"Visintini Jaime","year":"2013","journal-title":"Virol J"},{"issue":"6","key":"10.1002\/ptr.5765-BIB0041|ptr5765-cit-0042","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1002\/hep.23587","article-title":"Multiple effects of silymarin on the hepatitis C virus lifecycle","volume":"51","author":"Wagoner","year":"2010","journal-title":"Hepatology"},{"key":"10.1002\/ptr.5765-BIB0042|ptr5765-cit-0043","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.meegid.2012.12.004","article-title":"RNA dependent RNA polymerase of HCV: a potential target for the development of antiviral drugs","volume":"14","author":"Waheed","year":"2013","journal-title":"Infect Genet Evol"},{"key":"10.1002\/ptr.5765-BIB0047|ptr5765-cit-0048","unstructured":"World Health Organization 2016 Hepatitis C, Fact sheet no 164, world health organization, Geneva, Switzerland http:\/\/www.who.int\/mediacentre\/factsheets\/fs164\/en\/"},{"issue":"6","key":"10.1002\/ptr.5765-BIB0043|ptr5765-cit-0044","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.coviro.2011.10.019","article-title":"Anti-HCV drugs in the pipeline","volume":"1","author":"Yang","year":"2011","journal-title":"Curr Opin Virol"},{"issue":"7","key":"10.1002\/ptr.5765-BIB0044|ptr5765-cit-0045","doi-asserted-by":"crossref","first-page":"6048","DOI":"10.1128\/JVI.72.7.6048-6055.1998","article-title":"The native form and maturation process of hepatitis C virus core protein","volume":"72","author":"Yasui","year":"1998","journal-title":"J Virol"},{"issue":"25","key":"10.1002\/ptr.5765-BIB0045|ptr5765-cit-0046","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1056\/NEJMoa1013086","article-title":"Telaprevir for retreatment of HCV infection","volume":"364","author":"Zeuzem","year":"2011","journal-title":"N Engl J Med"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.5765","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/ptr.5765","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T12:34:04Z","timestamp":1658406844000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.5765"}},"subtitle":["Anti-HCV Activity from<i>Valeriana wallichii<\/i>Root Extract"],"short-title":[],"issued":{"date-parts":[[2017,1,12]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"URL":"https:\/\/doi.org\/10.1002\/ptr.5765","archive":["Portico"],"relation":{},"ISSN":["0951-418X"],"issn-type":[{"value":"0951-418X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1,12]]}}}