{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:02:20Z","timestamp":1791385340124,"version":"4.3.3"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,2,8]],"date-time":"2017-02-08T00:00:00Z","timestamp":1486512000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"},{"start":{"date-parts":[[2017,2,8]],"date-time":"2017-02-08T00:00:00Z","timestamp":1486512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions"}],"funder":[{"DOI":"10.13039\/501100000276","name":"Department of Health","doi-asserted-by":"publisher","award":["10301-62-024"],"award-info":[{"award-number":["10301-62-024"]}],"id":[{"id":"10.13039\/501100000276","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytother. Res."],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1002\/ptr.5777","type":"journal-article","created":{"date-parts":[[2017,2,8]],"date-time":"2017-02-08T06:21:07Z","timestamp":1486534867000},"page":"638-646","source":"Crossref","is-referenced-by-count":47,"title":["Cryptotanshinone Inhibits STAT3 Signaling to Alleviate Cardiac Fibrosis in Type 1-like Diabetic Rats"],"prefix":"10.1002","volume":"31","author":[{"given":"Shih-Hsiang","family":"Lo","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine; Zhongxing Branch of Taipei City Hospital; Taipei City 10341 Taiwan"},{"name":"Department of Nursing; Tzu Chi University of Science and Technology; Hualien City 97041 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-Tien","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Pathology, E-DA Hospital; I-Shou University; Yanchao Kaohsiung City 82401 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho-Shan","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Nursing; Tzu Chi University of Science and Technology; Hualien City 97041 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiang-Shan","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Nursing; Tzu Chi University of Science and Technology; Hualien City 97041 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4522-584X","authenticated-orcid":false,"given":"Juei-Tang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Cardiology; Chi-Mei Medical Center; Yong Kang Tainan City 71003 Taiwan"},{"name":"Department of Medical Research; Chi-Mei Medical Center; Yong Kang Tainan City 71003 Taiwan"},{"name":"Institute of Medical Sciences; Chang Jung Christian University; Guiren Tainan City 71101 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhih-Cherng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology; Chi-Mei Medical Center; Yong Kang Tainan City 71003 Taiwan"},{"name":"Department of Medical Research; Chi-Mei Medical Center; Yong Kang Tainan City 71003 Taiwan"},{"name":"Department of Pharmacy; Chia Nan University of Pharmacy & Science; Jean-Tae City Tainan County 71701 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,8]]},"reference":[{"issue":"3","key":"10.1002\/ptr.5777-BIB0001|ptr5777-cit-0002","first-page":"178","article-title":"The expression of STAT3, BCL-XL and MMP-2 proteins in colon adenocarcinomas and their relationship with prognostic factors","volume":"30","author":"Artas","year":"2014","journal-title":"Turk patoloji dergisi"},{"issue":"10","key":"10.1002\/ptr.5777-BIB0002|ptr5777-cit-0003","doi-asserted-by":"crossref","first-page":"2949","DOI":"10.2337\/diacare.26.10.2949","article-title":"Diabetic cardiomyopathy","volume":"26","author":"Bell","year":"2003","journal-title":"Diabetes Care"},{"key":"10.1002\/ptr.5777-BIB0003|ptr5777-cit-0004","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/978-1-4939-1215-5_22","article-title":"Generating double knockout mice to model genetic intervention for diabetic cardiomyopathy in humans","volume":"1194","author":"Chavali","year":"2014","journal-title":"Methods Mol Biol"},{"issue":"2","key":"10.1002\/ptr.5777-BIB0004|ptr5777-cit-0005","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1111\/j.1476-5381.2011.01212.x","article-title":"Characterization of the mechanisms of the increase in PPARdelta expression induced by digoxin in the heart using the H9c2 cell line","volume":"163","author":"Chen","year":"2011","journal-title":"Br J Pharmacol"},{"issue":"3","key":"10.1002\/ptr.5777-BIB0005|ptr5777-cit-0006","doi-asserted-by":"crossref","first-page":"819","DOI":"10.2337\/diabetes.55.03.06.db05-0934","article-title":"Novel mechanism for plasma glucose-lowering action of metformin in streptozotocin-induced diabetic rats","volume":"55","author":"Cheng","year":"2006","journal-title":"Diabetes"},{"issue":"5","key":"10.1002\/ptr.5777-BIB0006|ptr5777-cit-0007","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1248\/bpb.33.768","article-title":"Janus kinase 2\/signal transducers and activators of transcription signal inhibition regulates protective effects of probucol on mesangial cells treated with high glucose","volume":"33","author":"Du","year":"2010","journal-title":"Biol Pharm Bull"},{"issue":"4","key":"10.1002\/ptr.5777-BIB0007|ptr5777-cit-0008","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.curtheres.2010.08.004","article-title":"Pharmacokinetics of depside salts from Salvia miltiorrhiza in healthy Chinese volunteers: a randomized, open-label, single-dose study","volume":"71","author":"Jia","year":"2010","journal-title":"Curr Ther Res Clin Exp"},{"key":"10.1002\/ptr.5777-BIB0008|ptr5777-cit-0009","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1155\/2016\/9150108","article-title":"Molecular mechanisms of cardioprotective actions of Tanshinones","volume":"2016","author":"Jin","year":"2016","journal-title":"J Chemistry"},{"issue":"1","key":"10.1002\/ptr.5777-BIB0009|ptr5777-cit-0010","doi-asserted-by":"crossref","first-page":"e51720","DOI":"10.1371\/journal.pone.0051720","article-title":"Tanshinone IIA and cryptotanshinone protect against hypoxia-induced mitochondrial apoptosis in H9c2 cells","volume":"8","author":"Jin","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"10.1002\/ptr.5777-BIB0010|ptr5777-cit-0011","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1124\/mol.107.034447","article-title":"Antidiabetes and antiobesity effect of cryptotanshinone via activation of AMP-activated protein kinase","volume":"72","author":"Kim","year":"2007","journal-title":"Mol Pharmacol"},{"issue":"9378","key":"10.1002\/ptr.5777-BIB0011|ptr5777-cit-0012","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0140-6736(03)13869-X","article-title":"Demographics and concomitant disorders in heart failure","volume":"362","author":"Krum","year":"2003","journal-title":"Lancet"},{"issue":"11","key":"10.1002\/ptr.5777-BIB0012|ptr5777-cit-0013","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.2337\/db10-1333","article-title":"Targeted inhibition of calpain reduces myocardial hypertrophy and fibrosis in mouse models of type 1 diabetes","volume":"60","author":"Li","year":"2011","journal-title":"Diabetes"},{"key":"10.1002\/ptr.5777-BIB0013|ptr5777-cit-0014","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/1475-2840-11-73","article-title":"Cardiac fibrosis and dysfunction in experimental diabetic cardiomyopathy are ameliorated by alpha-lipoic acid","volume":"11","author":"Li","year":"2012","journal-title":"Cardiovasc Diabetol"},{"issue":"6","key":"10.1002\/ptr.5777-BIB0014|ptr5777-cit-0015","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.3892\/or.2013.2748","article-title":"Resveratrol suppresses the STAT3 signaling pathway and inhibits proliferation of high glucose-exposed HepG2 cells partly through SIRT1","volume":"30","author":"Li","year":"2013","journal-title":"Oncol Rep"},{"issue":"1-2","key":"10.1002\/ptr.5777-BIB0015|ptr5777-cit-0016","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s11010-015-2424-0","article-title":"Cryptotanshinone, a Stat3 inhibitor, suppresses colorectal cancer proliferation and growth in vitro","volume":"406","author":"Li","year":"2015","journal-title":"Mol Cell Biochem"},{"issue":"8-9","key":"10.1002\/ptr.5777-BIB0016|ptr5777-cit-0017","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.phymed.2012.04.007","article-title":"Allicin protects against myocardial apoptosis and fibrosis in streptozotocin-induced diabetic rats","volume":"19","author":"Liu","year":"2012","journal-title":"Phytomedicine"},{"issue":"42","key":"10.1002\/ptr.5777-BIB0017|ptr5777-cit-0018","doi-asserted-by":"crossref","first-page":"30708","DOI":"10.1074\/jbc.M113.478685","article-title":"Transforming growth factor-beta (TGF-beta)-mediated connective tissue growth factor (CTGF) expression in hepatic stellate cells requires Stat3 signaling activation","volume":"288","author":"Liu","year":"2013","journal-title":"J Biol Chem"},{"key":"10.1002\/ptr.5777-BIB0018|ptr5777-cit-0019","first-page":"145","article-title":"Cryptotanshinone attenuates isoprenaline-induced cardiac fibrosis in mice associated with upregulation and activation of matrix metalloproteinase-2","volume":"6","author":"Ma","year":"2012","journal-title":"Mol Med Report"},{"issue":"1","key":"10.1002\/ptr.5777-BIB0019|ptr5777-cit-0020","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1097\/FJC.0000000000000086","article-title":"Cryptotanshinone attenuates cardiac fibrosis via downregulation of COX-2, NOX-2, and NOX-4","volume":"64","author":"Ma","year":"2014","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1002\/ptr.5777-BIB0020|ptr5777-cit-0021","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.2741\/3886","article-title":"JAK-STAT signaling in hepatic fibrosis","volume":"16","author":"Mair","year":"2011","journal-title":"Front Biosci (Landmark Ed)"},{"key":"10.1002\/ptr.5777-BIB0021|ptr5777-cit-0022","doi-asserted-by":"crossref","first-page":"2742","DOI":"10.1016\/j.fct.2009.08.007","article-title":"Preventive effects of a purified extract isolated from Salvia miltiorrhiza enriched with tanshinone I, tanshinone IIA and cryptotanshinone on hepatocyte injury in vitro and in vivo","volume":"47","author":"Park","year":"2009","journal-title":"Food Chem Toxicol"},{"issue":"13","key":"10.1002\/ptr.5777-BIB0022|ptr5777-cit-0023","doi-asserted-by":"crossref","first-page":"8076","DOI":"10.1167\/iovs.12-10790","article-title":"Effect of connective tissue growth factor on protein kinase expression and activity in human corneal fibroblasts","volume":"53","author":"Radhakrishnan","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"10.1002\/ptr.5777-BIB0023|ptr5777-cit-0024","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","article-title":"Dose translation from animal to human studies revisited","volume":"22","author":"Reagan-Shaw","year":"2008","journal-title":"FASEB J"},{"key":"10.1002\/ptr.5777-BIB0024|ptr5777-cit-0025","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jep.2014.08.023","article-title":"Study of the protective mechanisms of Compound Danshen tablet (Fufang Danshen Pian) against myocardial ischemia\/reperfusion injury via the Akt-eNOS signaling pathway in rats","volume":"156","author":"Ren-an","year":"2014","journal-title":"J Ethnopharmacol"},{"issue":"1","key":"10.1002\/ptr.5777-BIB0025|ptr5777-cit-0026","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1158\/0008-5472.CAN-10-2193","article-title":"Molecular pathobiology of human cervical high-grade lesions: paracrine STAT3 activation in tumor-instructed myeloid cells drives local MMP-9 expression","volume":"71","author":"Schroer","year":"2011","journal-title":"Cancer Res"},{"key":"10.1002\/ptr.5777-BIB0026|ptr5777-cit-0027","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1080\/02841850802133386","article-title":"Catheter replacement of the needle in percutaneous arteriography. A new technique","volume":"434","author":"Seldinger","year":"2008","journal-title":"Acta Radiol Suppl"},{"key":"10.1002\/ptr.5777-BIB0027|ptr5777-cit-0028","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jep.2014.09.035","article-title":"Shensong Yangxin capsule prevents diabetic myocardial fibrosis by inhibitingTGF-\u03b21\/Smad signaling","volume":"157","author":"Shen","year":"2014","journal-title":"J Ethnopharmacol"},{"issue":"1","key":"10.1002\/ptr.5777-BIB0028|ptr5777-cit-0029","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1158\/0008-5472.CAN-08-2575","article-title":"Cryptotanshinone inhibits constitutive signal transducer and activator of transcription 3 function through blocking the dimerization in DU145 prostate cancer cells","volume":"69","author":"Shin","year":"2009","journal-title":"Cancer Res"},{"issue":"5","key":"10.1002\/ptr.5777-BIB0029|ptr5777-cit-0030","first-page":"759","article-title":"Protective effects of valsartan and benazepril combined with atorvastatin on cardiorenal syndrome in rats","volume":"19","author":"Tang","year":"2015","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10.1002\/ptr.5777-BIB0030|ptr5777-cit-0031","doi-asserted-by":"crossref","first-page":"883","DOI":"10.2147\/VHRM.S11681","article-title":"Diabetic cardiomyopathy: from the pathophysiology of the cardiac myocytes to current diagnosis and management strategies","volume":"6","author":"Voulgari","year":"2010","journal-title":"Vasc Health Risk Manag"},{"key":"10.1002\/ptr.5777-BIB0031|ptr5777-cit-0032","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/1479-5876-10-145","article-title":"Effect of obesity reduction on preservation of heart function and attenuation of left ventricular remodeling, oxidative stress and inflammation in obese mice","volume":"10","author":"Wang","year":"2012","journal-title":"J Transl Med"},{"issue":"2","key":"10.1002\/ptr.5777-BIB0032|ptr5777-cit-0033","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.diabres.2014.01.031","article-title":"The impact of 1,25-dihydroxyvitamin D3 on the expression of connective tissue growth factor and transforming growth factor-beta1 in the myocardium of rats with diabetes","volume":"104","author":"Wang","year":"2014","journal-title":"Diabetes Res Clin Pract"},{"issue":"3","key":"10.1002\/ptr.5777-BIB0033|ptr5777-cit-0034","doi-asserted-by":"crossref","first-page":"641","DOI":"10.2337\/db06-1163","article-title":"Contributions of inflammation and cardiac matrix metalloproteinase activity to cardiac failure in diabetic cardiomyopathy: the role of angiotensin type 1 receptor antagonism","volume":"56","author":"Westermann","year":"2007","journal-title":"Diabetes"},{"key":"10.1002\/ptr.5777-BIB0034|ptr5777-cit-0035","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.neulet.2014.09.008","article-title":"Signals for increase of mu-opioid receptor expression in muscle by hyperglycemia","volume":"582","author":"Yeh","year":"2014","journal-title":"Neurosci Lett"},{"key":"10.1002\/ptr.5777-BIB0035|ptr5777-cit-0036","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2147\/DMSO.S50209","article-title":"TRC210258, a novel TGR5 agonist, reduces glycemic and dyslipidemic cardiovascular risk in animal models of diabesity","volume":"7","author":"Zambad","year":"2013","journal-title":"Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy"},{"key":"10.1002\/ptr.5777-BIB0036|ptr5777-cit-0037","first-page":"1","article-title":"Cryptotanshinone protects against adriamycin-induced mitochondrial dysfunction in cardiomyocytes","volume":"2015","author":"Zhang","year":"2015","journal-title":"Pharm Biol"},{"issue":"12","key":"10.1002\/ptr.5777-BIB0037|ptr5777-cit-0038","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1177\/0091270005282630","article-title":"Danshen: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use","volume":"45","author":"Zhou","year":"2005","journal-title":"J Clin Pharmacol"},{"issue":"1-2","key":"10.1002\/ptr.5777-BIB0038|ptr5777-cit-0039","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s11010-012-1398-4","article-title":"The effects of homocysteine-related compounds on cardiac contractility, coronary flow, and oxidative stress markers in isolated rat heart","volume":"370","author":"Zivkovic","year":"2012","journal-title":"Mol Cell Biochem"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.5777","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/ptr.5777","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,4]],"date-time":"2021-07-04T02:34:29Z","timestamp":1625366069000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.5777"}},"subtitle":["Cryptotanshinone for Cardiac Fibrosis in Diabetic Rats"],"short-title":[],"issued":{"date-parts":[[2017,2,8]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"URL":"https:\/\/doi.org\/10.1002\/ptr.5777","archive":["Portico"],"relation":{},"ISSN":["0951-418X"],"issn-type":[{"value":"0951-418X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2,8]]}}}